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Impact of age on outcomes in young women with breast cancer

Impact of age on outcomes in young women with breast cancer INTRODUCTIONBreast cancer (BC) in young women is a relatively uncommon problem but represents a special population of BC patients. The definition of young age varies across the studies in the literature from 50 to 35 years or even premenopausal patients with BC. The incidence of BC in women <35 years of age is 2%.1 They have worse outcomes as compared to older counterparts.2,3 This worse outcome is related to age or other prognostic factors of the BC itself. It has been reported that young patients with BC tend to present in an advanced stage, higher grade, more positive nodes, higher estrogen receptor/progesterone receptor (ER/PR) negative tumors, and higher expression of Her2/neu.4–8 This might be because these patients are not part of screening programs. It is not clear whether young age should be independently considered in treatment decisions and whether it is applicable to very young patients as well. Most of the data on young patients with BC is from the western world. Data from Asia is lacking. In this study, we compared outcomes in young and very young women with BC.MATERIAL AND METHODSIn this retrospective analysis, 414 young women (age ≤ 35 years) with primary BC were registered in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asia-Pacific Journal of Clinical Oncology Wiley

Impact of age on outcomes in young women with breast cancer

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Publisher
Wiley
Copyright
© 2023 John Wiley & Sons Australia, Ltd.
ISSN
1743-7555
eISSN
1743-7563
DOI
10.1111/ajco.13945
Publisher site
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Abstract

INTRODUCTIONBreast cancer (BC) in young women is a relatively uncommon problem but represents a special population of BC patients. The definition of young age varies across the studies in the literature from 50 to 35 years or even premenopausal patients with BC. The incidence of BC in women <35 years of age is 2%.1 They have worse outcomes as compared to older counterparts.2,3 This worse outcome is related to age or other prognostic factors of the BC itself. It has been reported that young patients with BC tend to present in an advanced stage, higher grade, more positive nodes, higher estrogen receptor/progesterone receptor (ER/PR) negative tumors, and higher expression of Her2/neu.4–8 This might be because these patients are not part of screening programs. It is not clear whether young age should be independently considered in treatment decisions and whether it is applicable to very young patients as well. Most of the data on young patients with BC is from the western world. Data from Asia is lacking. In this study, we compared outcomes in young and very young women with BC.MATERIAL AND METHODSIn this retrospective analysis, 414 young women (age ≤ 35 years) with primary BC were registered in

Journal

Asia-Pacific Journal of Clinical Oncology – Wiley

Published: Mar 23, 2023

Keywords: breast cancer; outcomes; treatment; young patients

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