Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Increased levels of SNAP‐25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

Increased levels of SNAP‐25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I... Objective: In order to identify whether the mechanisms associated with neurotransmitter release are involved in the pathologies of bipolar disorder and schizophrenia, levels of presynaptic (synaptosomal‐associated protein‐25 (SNAP‐25), syntaxin, synaptophysin, vesicle‐associated membrane protein, dynamin I) and structural (neuronal cell adhesion molecule and alpha‐synuclein) neuronal markers were measured in Brodmann's area 9 obtained postmortem from eight subjects with bipolar I disorder (BPDI), 20 with schizophrenia and 20 controls. Methods: Determinations of protein levels were carried out using Western blot techniques with specific antibodies. Levels of mRNA were measured using real‐time polymerase chain reaction. Results: In BPDI, levels of SNAP‐25 (p < 0.01) and synaptophysin (p < 0.05) increased. There were no changes in schizophrenia or any other changes in BPDI. Levels of mRNA for SNAP‐25 were decreased in BPDI (p < 0.05). Conclusion: Changes in SNAP‐25 and synaptophysin in BPDI suggest that changes in specific neuronal functions could be linked to the pathology of the disorder. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bipolar Disorders Wiley

Increased levels of SNAP‐25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

Bipolar Disorders , Volume 8 (2) – Apr 1, 2006

Loading next page...
 
/lp/wiley/increased-levels-of-snap-25-and-synaptophysin-in-the-dorsolateral-DAT1aYiovn

References (62)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1398-5647
eISSN
1399-5618
DOI
10.1111/j.1399-5618.2006.00300.x
pmid
16542183
Publisher site
See Article on Publisher Site

Abstract

Objective: In order to identify whether the mechanisms associated with neurotransmitter release are involved in the pathologies of bipolar disorder and schizophrenia, levels of presynaptic (synaptosomal‐associated protein‐25 (SNAP‐25), syntaxin, synaptophysin, vesicle‐associated membrane protein, dynamin I) and structural (neuronal cell adhesion molecule and alpha‐synuclein) neuronal markers were measured in Brodmann's area 9 obtained postmortem from eight subjects with bipolar I disorder (BPDI), 20 with schizophrenia and 20 controls. Methods: Determinations of protein levels were carried out using Western blot techniques with specific antibodies. Levels of mRNA were measured using real‐time polymerase chain reaction. Results: In BPDI, levels of SNAP‐25 (p < 0.01) and synaptophysin (p < 0.05) increased. There were no changes in schizophrenia or any other changes in BPDI. Levels of mRNA for SNAP‐25 were decreased in BPDI (p < 0.05). Conclusion: Changes in SNAP‐25 and synaptophysin in BPDI suggest that changes in specific neuronal functions could be linked to the pathology of the disorder.

Journal

Bipolar DisordersWiley

Published: Apr 1, 2006

There are no references for this article.