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Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation

Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin... DOI: 10.1111/exd.12797 Letter to the Editor www.wileyonlinelibrary.com/journal/EXD Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation 1 1 1 1,2 Hsien-Yi Lin , Pei-Hsuan Lin , Shu-Hui Wu and Liang-Tung Yang 1 2 Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Graduate Institute of Molecular Systems Biomedicine, China Medical University, Taichung, Taiwan Correspondonce: Liang-Tung Yang, PhD, National Health Research Institutes, 35, Keyan Rd. Zhunan, Miaoli County 35053, Taiwan, Tel.: +886-37- 246-166 ext. 37521, Fax: +886-37-587-408, e-mail: ltyang@nhri.org.tw Key words: Epidermal hyperplasia – epidermis – gasdermin A3 – necrosis – Accepted for publication 2 July 2015 skin inflammation Background back skin sections of control and DTg mice (Fig. 1d). We found The epidermis forms a critical barrier to defend against environ- that K14 expression was expanded to the suprabasal keratinocytes mental insults. It is maintained by epidermal keratinocytes under- and K10-expressing suprabasal cell layer was also expanded in the going an orchestrated programme of proliferation, differentiation DTg epidermis compared with the control epidermis, while and death, which could be disrupted by gene mutations and cause expression of loricrin, filaggrin and K6 in the DTg epidermis was skin diseases. Gasdermin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Dermatology Wiley

Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation

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References (9)

Publisher
Wiley
Copyright
"© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd"
ISSN
0906-6705
eISSN
1600-0625
DOI
10.1111/exd.12797
pmid
26173759
Publisher site
See Article on Publisher Site

Abstract

DOI: 10.1111/exd.12797 Letter to the Editor www.wileyonlinelibrary.com/journal/EXD Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation 1 1 1 1,2 Hsien-Yi Lin , Pei-Hsuan Lin , Shu-Hui Wu and Liang-Tung Yang 1 2 Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan; Graduate Institute of Molecular Systems Biomedicine, China Medical University, Taichung, Taiwan Correspondonce: Liang-Tung Yang, PhD, National Health Research Institutes, 35, Keyan Rd. Zhunan, Miaoli County 35053, Taiwan, Tel.: +886-37- 246-166 ext. 37521, Fax: +886-37-587-408, e-mail: ltyang@nhri.org.tw Key words: Epidermal hyperplasia – epidermis – gasdermin A3 – necrosis – Accepted for publication 2 July 2015 skin inflammation Background back skin sections of control and DTg mice (Fig. 1d). We found The epidermis forms a critical barrier to defend against environ- that K14 expression was expanded to the suprabasal keratinocytes mental insults. It is maintained by epidermal keratinocytes under- and K10-expressing suprabasal cell layer was also expanded in the going an orchestrated programme of proliferation, differentiation DTg epidermis compared with the control epidermis, while and death, which could be disrupted by gene mutations and cause expression of loricrin, filaggrin and K6 in the DTg epidermis was skin diseases. Gasdermin

Journal

Experimental DermatologyWiley

Published: Nov 1, 2015

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