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Interleukin‐1

Interleukin‐1 A New Mediator in Dermatology GoRM LisBY, M.D., CHRISTIAN AVNSTORP, M.D., AND GLINMIID LANCE M.D. frtim the Dcpartmvnl ot Dorm.Unlo^y, fiisprh/tT^j University c CriponfM^'t'n, Copenhagen, Denmjrk W Molecular Structure It is possible that IL-1 consists of several (losoly related molecules. The most frcqur-ntly reported human and murine IL-1 has a tnoletular weight ol 1 i,(X)O 17,5{M)/ ' but higher mole( ular weights - u p to 85,000 have been reported.''"'' Furthermore, it has been noted that II 1 is able to fragment into 4000dalton polypeptides and still retain the IL-1 capabilities.'" Recently, two distim t cDNAs, encoding proteins with human IL 1 activity (called IL-lw and IL-1/3),"'^ have been isolated. These cDNAs encode IL-1 precursors with mole( ular weights of approximately 30,000 that arc proteolytically cleaved to 17,500-dalton active torms.''" I Umian l l - l w shows fj2"/fi hritiiology to niurinc I I - 1 , bul only 2t>'M> hotnology to human ILthis diversity, the two IL-1 molecules seem to have sirnilar biologic a< tivitios'' and bitid to the same receptor.'*'' The number of isoelectric points arc reported to be one, two, or three (pi 'j 7 ) / ' ' " ' ' ' ' IL-1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Dermatology Wiley

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References (92)

Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0011-9059
eISSN
1365-4632
DOI
10.1111/j.1365-4362.1987.tb04568.x
Publisher site
See Article on Publisher Site

Abstract

A New Mediator in Dermatology GoRM LisBY, M.D., CHRISTIAN AVNSTORP, M.D., AND GLINMIID LANCE M.D. frtim the Dcpartmvnl ot Dorm.Unlo^y, fiisprh/tT^j University c CriponfM^'t'n, Copenhagen, Denmjrk W Molecular Structure It is possible that IL-1 consists of several (losoly related molecules. The most frcqur-ntly reported human and murine IL-1 has a tnoletular weight ol 1 i,(X)O 17,5{M)/ ' but higher mole( ular weights - u p to 85,000 have been reported.''"'' Furthermore, it has been noted that II 1 is able to fragment into 4000dalton polypeptides and still retain the IL-1 capabilities.'" Recently, two distim t cDNAs, encoding proteins with human IL 1 activity (called IL-lw and IL-1/3),"'^ have been isolated. These cDNAs encode IL-1 precursors with mole( ular weights of approximately 30,000 that arc proteolytically cleaved to 17,500-dalton active torms.''" I Umian l l - l w shows fj2"/fi hritiiology to niurinc I I - 1 , bul only 2t>'M> hotnology to human ILthis diversity, the two IL-1 molecules seem to have sirnilar biologic a< tivitios'' and bitid to the same receptor.'*'' The number of isoelectric points arc reported to be one, two, or three (pi 'j 7 ) / ' ' " ' ' ' ' IL-1

Journal

International Journal of DermatologyWiley

Published: Jan 1, 1987

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