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Intra‐individual variability in genetic and environmental models of attention‐deficit/hyperactivity disorder

Intra‐individual variability in genetic and environmental models of... The frequent observation of intra‐individual variability (IIV) in the expression of ADHD symptoms suggest that IIV is an integral component of the disorder. We tested IIV in ADHD‐like phenotype from five different studies of rodent models of ADHD, including studies with Spontaneous Hypertensive Rats (SHR/NCrl and SHR/N), Wistar‐Kyoto Hyperactive Rats (WKHA/N), Wistar‐Kyoto Hypertensive rat (WKHT), PCB‐126 and ‐153‐treated Lewis rats and behaviorally normal Wistar/Mol, Wistar‐Kyoto (WKY/N and WKY/NMol), and untreated Lewis rats. Averages of the absolute residual deviation of ADHD‐like behavior from individual means (“individual phenotypic dispersion,” PDi) were used to represent IIV in the fixed‐interval (FI) and extinction (EXT) phases of operant behavioral activity. Across all studies, SHR rats had higher PDi than WKY rats (P < 0.0001) for all ADHD‐like traits, and higher PDi for hyperactivity than WKHT and WKHA/N rats. Male SHR rats in particular had higher PDi for hyperactivity than male or female WKYs, SHR females for EXT hyperactivity, and higher dispersion for inattention than WKY females. These findings strongly suggest the genetic control of IIV, and suggest that the SHR may be a useful model for the identification of genes for IIV in human ADHD. These findings also obliquely support the SHR as a useful model for ADHD overall. © 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Part A Wiley

Intra‐individual variability in genetic and environmental models of attention‐deficit/hyperactivity disorder

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References (81)

Publisher
Wiley
Copyright
"Copyright © 2010 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1552-4825
eISSN
1552-4833
DOI
10.1002/ajmg.b.31070
pmid
20468058
Publisher site
See Article on Publisher Site

Abstract

The frequent observation of intra‐individual variability (IIV) in the expression of ADHD symptoms suggest that IIV is an integral component of the disorder. We tested IIV in ADHD‐like phenotype from five different studies of rodent models of ADHD, including studies with Spontaneous Hypertensive Rats (SHR/NCrl and SHR/N), Wistar‐Kyoto Hyperactive Rats (WKHA/N), Wistar‐Kyoto Hypertensive rat (WKHT), PCB‐126 and ‐153‐treated Lewis rats and behaviorally normal Wistar/Mol, Wistar‐Kyoto (WKY/N and WKY/NMol), and untreated Lewis rats. Averages of the absolute residual deviation of ADHD‐like behavior from individual means (“individual phenotypic dispersion,” PDi) were used to represent IIV in the fixed‐interval (FI) and extinction (EXT) phases of operant behavioral activity. Across all studies, SHR rats had higher PDi than WKY rats (P < 0.0001) for all ADHD‐like traits, and higher PDi for hyperactivity than WKHT and WKHA/N rats. Male SHR rats in particular had higher PDi for hyperactivity than male or female WKYs, SHR females for EXT hyperactivity, and higher dispersion for inattention than WKY females. These findings strongly suggest the genetic control of IIV, and suggest that the SHR may be a useful model for the identification of genes for IIV in human ADHD. These findings also obliquely support the SHR as a useful model for ADHD overall. © 2010 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics Part AWiley

Published: Jul 1, 2010

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