Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Kaposi's sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV infection

Kaposi's sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV... We report 100 cases of Kaposi's sarcoma (KS) in children under 15 years of age treated at the Uganda Cancer Institute in the 6‐year period 1989–1994. The incidence of childhood KS has risen more than 40‐fold in the era of AIDS, and 78% of 63 cases tested were seropositive for HIV‐I. There were 63 boys and 37 girls. The median age was 4 years and the median age of onset was 33 months. Tumour distribution was lymphadenopathic and muco‐cutaneous, with 2 major patterns: pattern I, oro‐facial dominant (79%); and pattern II, inguinal‐genital dominant (13%). A newly described herpes‐like virus is implicated as the cause of KS (KSHV), and DNA sequences of this virus were present in all of 8 childhood cases tested. If KSHV is a direct cause of KS, this tumour distribution in children suggests mucosal routes of virus entry, possibly during birth or breast feeding. The dramatic increase of childhood KS implies that the prevalence of causative factors is rising in Uganda. © 1996 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Cancer Wiley

Kaposi's sarcoma in childhood: An analysis of 100 cases from Uganda and relationship to HIV infection

Loading next page...
 
/lp/wiley/kaposi-s-sarcoma-in-childhood-an-analysis-of-100-cases-from-uganda-and-AG53bJhlUn

References (14)

Publisher
Wiley
Copyright
Copyright © 1996 Wiley Subscription Services
ISSN
0020-7136
eISSN
1097-0215
DOI
10.1002/(SICI)1097-0215(19960117)65:2<200::AID-IJC12>3.0.CO;2-H
pmid
8567117
Publisher site
See Article on Publisher Site

Abstract

We report 100 cases of Kaposi's sarcoma (KS) in children under 15 years of age treated at the Uganda Cancer Institute in the 6‐year period 1989–1994. The incidence of childhood KS has risen more than 40‐fold in the era of AIDS, and 78% of 63 cases tested were seropositive for HIV‐I. There were 63 boys and 37 girls. The median age was 4 years and the median age of onset was 33 months. Tumour distribution was lymphadenopathic and muco‐cutaneous, with 2 major patterns: pattern I, oro‐facial dominant (79%); and pattern II, inguinal‐genital dominant (13%). A newly described herpes‐like virus is implicated as the cause of KS (KSHV), and DNA sequences of this virus were present in all of 8 childhood cases tested. If KSHV is a direct cause of KS, this tumour distribution in children suggests mucosal routes of virus entry, possibly during birth or breast feeding. The dramatic increase of childhood KS implies that the prevalence of causative factors is rising in Uganda. © 1996 Wiley‐Liss, Inc.

Journal

International Journal of CancerWiley

Published: Jan 17, 1996

There are no references for this article.