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Kidney function impairment in men with primary infertility: A case–control analysis

Kidney function impairment in men with primary infertility: A case–control analysis INTRODUCTIONMale factor infertility (MFI) has been found in almost 50% of infertile couples, representing the sole cause of infertility in almost 20% of infertile cases.1–3 Over the last decades, numerous studies have depicted an association between primary infertility and a number of comorbidities, thus including oncologic and non‐oncologic chronic systemic diseases (e.g., obesity, prediabetes, diabetes mellitus, and hypertension).4–13 In addition, recent reports have suggested a higher risk of cardiovascular disease and overall mortality in primary infertile men than in their fertile counterparts.14–18 Of clinical relevance, many risk factors—for example, diabetes, hypertension, metabolic syndrome, and cigarette smoking—are shared between cardiovascular disease and chronic kidney disease (CKD).19 According to international guidelines, CKD is a functional and anatomical alteration of the kidney defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2 and/or the presence of at least one marker of kidney damage (i.e., albuminuria, albumin:creatinine ratio ≥30 mg/g, urinary sediment abnormality, electrolyte abnormalities or other abnormalities due to tubular disorder, abnormalities on kidney histology, structural abnormalities or history of kidney transplantation).20The association between kidney function and male fertility status has been scarcely analyzed. Therefore, following the idea that there is a common ground fostering male health status and the reproductive profile, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Andrology Wiley

Kidney function impairment in men with primary infertility: A case–control analysis

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Publisher
Wiley
Copyright
© 2023 American Society of Andrology and European Academy of Andrology.
ISSN
2047-2919
eISSN
2047-2927
DOI
10.1111/andr.13425
Publisher site
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Abstract

INTRODUCTIONMale factor infertility (MFI) has been found in almost 50% of infertile couples, representing the sole cause of infertility in almost 20% of infertile cases.1–3 Over the last decades, numerous studies have depicted an association between primary infertility and a number of comorbidities, thus including oncologic and non‐oncologic chronic systemic diseases (e.g., obesity, prediabetes, diabetes mellitus, and hypertension).4–13 In addition, recent reports have suggested a higher risk of cardiovascular disease and overall mortality in primary infertile men than in their fertile counterparts.14–18 Of clinical relevance, many risk factors—for example, diabetes, hypertension, metabolic syndrome, and cigarette smoking—are shared between cardiovascular disease and chronic kidney disease (CKD).19 According to international guidelines, CKD is a functional and anatomical alteration of the kidney defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2 and/or the presence of at least one marker of kidney damage (i.e., albuminuria, albumin:creatinine ratio ≥30 mg/g, urinary sediment abnormality, electrolyte abnormalities or other abnormalities due to tubular disorder, abnormalities on kidney histology, structural abnormalities or history of kidney transplantation).20The association between kidney function and male fertility status has been scarcely analyzed. Therefore, following the idea that there is a common ground fostering male health status and the reproductive profile,

Journal

Andrology – Wiley

Published: Mar 4, 2023

Keywords: chronic kidney disease; infertility; kidney; male factor infertility; men's health

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