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Lipid rafts in immune signalling: current progress and future perspective

Lipid rafts in immune signalling: current progress and future perspective Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and regulatory molecules and so act as a platform for signal transduction. They float freely within the liquid‐disordered bilayer of cellular membranes and can cluster to form larger ordered domains. Alterations in lipid rafts are commonly found to be associated with the pathogenesis of several human diseases and recent reports have shown that the raft domains can also be perturbed by targeting raft proteins through microRNAs. Over the last few years, the importance of lipid rafts in modulating both innate and acquired immune responses has been elucidated. Various receptors present on immune cells like B cells, T cells, basophils and mast cells associate with lipid rafts on ligand binding and initiate signalling cascades leading to inflammation. Furthermore, disrupting lipid raft integrity alters lipopolysaccharide‐induced cytokine secretion, IgE signalling, and B‐cell and T‐cell activation. The objective of this review is to summarize the recent progress in understanding the role of lipid rafts in the modulation of immune signalling and its related therapeutic potential for autoimmune diseases and inflammatory disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunology Wiley

Lipid rafts in immune signalling: current progress and future perspective

Immunology , Volume 149 (1) – Sep 1, 2016

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References (104)

Publisher
Wiley
Copyright
"Copyright © 2016 John Wiley & Sons Ltd"
ISSN
0019-2805
eISSN
1365-2567
DOI
10.1111/imm.12617
pmid
27153983
Publisher site
See Article on Publisher Site

Abstract

Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and regulatory molecules and so act as a platform for signal transduction. They float freely within the liquid‐disordered bilayer of cellular membranes and can cluster to form larger ordered domains. Alterations in lipid rafts are commonly found to be associated with the pathogenesis of several human diseases and recent reports have shown that the raft domains can also be perturbed by targeting raft proteins through microRNAs. Over the last few years, the importance of lipid rafts in modulating both innate and acquired immune responses has been elucidated. Various receptors present on immune cells like B cells, T cells, basophils and mast cells associate with lipid rafts on ligand binding and initiate signalling cascades leading to inflammation. Furthermore, disrupting lipid raft integrity alters lipopolysaccharide‐induced cytokine secretion, IgE signalling, and B‐cell and T‐cell activation. The objective of this review is to summarize the recent progress in understanding the role of lipid rafts in the modulation of immune signalling and its related therapeutic potential for autoimmune diseases and inflammatory disorders.

Journal

ImmunologyWiley

Published: Sep 1, 2016

Keywords: ; ; ; ; ; ;

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