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lncRNA ZEB2‐AS1: A promising biomarker in human cancers

lncRNA ZEB2‐AS1: A promising biomarker in human cancers Long non‐coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non‐coding zinc finger E‐box binding homeobox 2 antisense RNA1 (lnZEB2‐AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2‐AS1 can lead to tumorigenesis and cancer progression. lncZEB2‐AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2‐AS1 in cells and its function in cancer progression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

lncRNA ZEB2‐AS1: A promising biomarker in human cancers

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References (57)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2020 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1002/iub.2338
Publisher site
See Article on Publisher Site

Abstract

Long non‐coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non‐coding zinc finger E‐box binding homeobox 2 antisense RNA1 (lnZEB2‐AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2‐AS1 can lead to tumorigenesis and cancer progression. lncZEB2‐AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2‐AS1 in cells and its function in cancer progression.

Journal

IUBMB LifeWiley

Published: Sep 1, 2020

Keywords: ; ; ; ;

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