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Looking beyond the induction of Th2 responses to explain immunomodulation by helminths

Looking beyond the induction of Th2 responses to explain immunomodulation by helminths Summary Although helminth infections are characteristically associated with Th2‐mediated responses that include the production of the prototypical cytokines IL‐4, IL‐5 and IL‐13 by CD4+ cells, the production of IgE, peripheral blood eosinophilia and mucus production in localized sites, these responses are largely attenuated when helminth infections become less acute. This modulation of the immune response that occurs with chronic helminth infection is often induced by molecules secreted by helminth parasites, by non‐Th2 regulatory CD4+ cells, and by nonclassical B cells, macrophages and dendritic cells. This review will focus on those parasite‐ and host‐mediated mechanisms underlying the modulated T‐cell response that occurs as the default in chronic helminth infections. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parasite Immunology Wiley

Looking beyond the induction of Th2 responses to explain immunomodulation by helminths

Parasite Immunology , Volume 37 (6) – Jun 1, 2015

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References (136)

Publisher
Wiley
Copyright
Copyright © 2015 John Wiley & Sons Ltd
ISSN
0141-9838
eISSN
1365-3024
DOI
10.1111/pim.12194
pmid
25869527
Publisher site
See Article on Publisher Site

Abstract

Summary Although helminth infections are characteristically associated with Th2‐mediated responses that include the production of the prototypical cytokines IL‐4, IL‐5 and IL‐13 by CD4+ cells, the production of IgE, peripheral blood eosinophilia and mucus production in localized sites, these responses are largely attenuated when helminth infections become less acute. This modulation of the immune response that occurs with chronic helminth infection is often induced by molecules secreted by helminth parasites, by non‐Th2 regulatory CD4+ cells, and by nonclassical B cells, macrophages and dendritic cells. This review will focus on those parasite‐ and host‐mediated mechanisms underlying the modulated T‐cell response that occurs as the default in chronic helminth infections.

Journal

Parasite ImmunologyWiley

Published: Jun 1, 2015

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