Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring

Maternal exposures to endocrine disrupting chemicals and hypospadias in offspring BACKGROUND Prenatal exposures to endocrine‐disrupting chemicals (EDCs) are suspected risk factors in the etiology of hypospadias. The aim of this case‐control study was to test the hypothesis of an association between maternal environmental exposures to EDCs and hypospadias in the offspring. METHODS Detailed questionnaire data on occupational and dietary exposures to EDCs in the perinatal period were collected from 80 mothers with hypospadiac infants and from 80 mothers with healthy controls within 24 months of childbirth. Maternal exposure to selected EDCs was also ascertained by measuring the concentration of dichlorodiphenyldichloroethylene, hexachlorobenzene, and several polychlorinated biphenyl congeners in the serum of primiparous mothers of 37 cases and 21 controls. RESULTS The risk to bear an hypospadiac infant was associated with perinatal maternal occupational exposures to EDCs evaluated by a job‐exposure matrix: jobs with exposure to one class of EDCs (odds ratios (OR)crude, 2.83; 95% confidence intervals (CI), 1.32–6.07; ORadjusted, 2.44; 95% CI, 1.06–5.61) and jobs with exposure to more than one group of EDCs (ORcrude, 4.27; 95% CI, 1.43–12.78; ORadjusted, 4.11; 95%CI, 1.34–12.59). Increase in risk was also found among mothers consuming a diet rich in fish or shellfish (ORcrude, 3.41; 95% CI, 1.42–8.23; ORadjusted, 2.73; 95%CI, 1.09–6.82). Serum hexachlorobenzene concentration above the median of all subjects was significantly associated with the risk of hypospadias (ORadjusted, 5.50; 95% CI, 1.24–24.31). CONCLUSIONS This study, although based on a limited number of cases, for the first time provides evidence of an association between maternal exposure to EDCs, in particular elevated plasma hexachlorobenzene concentration, and the development of hypospadias in the offspring. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Birth Defects Research Part A Wiley

Loading next page...
 
/lp/wiley/maternal-exposures-to-endocrine-disrupting-chemicals-and-hypospadias-3sr2SyyvMA

References (42)

Publisher
Wiley
Copyright
Copyright © 2010 Wiley‐Liss, Inc., A Wiley Company
ISSN
1542-0752
eISSN
1542-0760
DOI
10.1002/bdra.20657
pmid
20196143
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND Prenatal exposures to endocrine‐disrupting chemicals (EDCs) are suspected risk factors in the etiology of hypospadias. The aim of this case‐control study was to test the hypothesis of an association between maternal environmental exposures to EDCs and hypospadias in the offspring. METHODS Detailed questionnaire data on occupational and dietary exposures to EDCs in the perinatal period were collected from 80 mothers with hypospadiac infants and from 80 mothers with healthy controls within 24 months of childbirth. Maternal exposure to selected EDCs was also ascertained by measuring the concentration of dichlorodiphenyldichloroethylene, hexachlorobenzene, and several polychlorinated biphenyl congeners in the serum of primiparous mothers of 37 cases and 21 controls. RESULTS The risk to bear an hypospadiac infant was associated with perinatal maternal occupational exposures to EDCs evaluated by a job‐exposure matrix: jobs with exposure to one class of EDCs (odds ratios (OR)crude, 2.83; 95% confidence intervals (CI), 1.32–6.07; ORadjusted, 2.44; 95% CI, 1.06–5.61) and jobs with exposure to more than one group of EDCs (ORcrude, 4.27; 95% CI, 1.43–12.78; ORadjusted, 4.11; 95%CI, 1.34–12.59). Increase in risk was also found among mothers consuming a diet rich in fish or shellfish (ORcrude, 3.41; 95% CI, 1.42–8.23; ORadjusted, 2.73; 95%CI, 1.09–6.82). Serum hexachlorobenzene concentration above the median of all subjects was significantly associated with the risk of hypospadias (ORadjusted, 5.50; 95% CI, 1.24–24.31). CONCLUSIONS This study, although based on a limited number of cases, for the first time provides evidence of an association between maternal exposure to EDCs, in particular elevated plasma hexachlorobenzene concentration, and the development of hypospadias in the offspring. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.

Journal

Birth Defects Research Part AWiley

Published: Apr 1, 2010

Keywords: hypospadias; risk factors; HCB; PCB; DDE

There are no references for this article.