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MicroRNA‐142‐5p induces cancer stem cell‐like properties of cutaneous squamous cell carcinoma via inhibiting PTEN

MicroRNA‐142‐5p induces cancer stem cell‐like properties of cutaneous squamous cell carcinoma via... INTRODUCTIONCutaneous squamous cell carcinoma (cSCC) is an epidermal keratinocyte‐derived skin tumor and it is the second most common skin cancer. Recently, with an increasing incidence, cSCC has contributed to approximately 20% of skin cancer‐related deaths. In spite of the accumulating advances in therapeutic approaches including surgery, chemotherapy and radiotherapy, the prognosis of the cSCC is still unfavorable. Generally, this cancer is very aggressive and malignant, which is prone to metastasis invasion and recurrences. Therefore, it is of great significance to explore more molecules in cSCC progression and develop more novel targets for cSCC treatment.MicroRNA (miRNA) is a kind of small noncoding RNA molecules, which is highly conserved and can induce mRNA cleavage or represses gene translation via targeting the 3′UTR of corresponding mRNAs.. The dysregulation of miRNA has played a crucial role in carcinogenesis, such as lung cancer, liver cancer, gastric cancer, and cSCC. For instance, in non‐small cell lung cancer, miR‐605 can promote cell proliferation, migration, and invasion through directly inhibiting LATS2. Via targeting Bcl‐2, miR‐365 can induce cell apoptosis of hepatocellular carcinoma. In gastric cancer, miR‐944 is able to inhibit metastasis by repressing the epithelial‐mesenchymal transition (EMT) process via MACC1/Met/AKT signaling pathway. MiR‐31 can play an oncogenic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular Biochemistry Wiley

MicroRNA‐142‐5p induces cancer stem cell‐like properties of cutaneous squamous cell carcinoma via inhibiting PTEN

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References (46)

Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0730-2312
eISSN
1097-4644
DOI
10.1002/jcb.26379
pmid
28857248
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCutaneous squamous cell carcinoma (cSCC) is an epidermal keratinocyte‐derived skin tumor and it is the second most common skin cancer. Recently, with an increasing incidence, cSCC has contributed to approximately 20% of skin cancer‐related deaths. In spite of the accumulating advances in therapeutic approaches including surgery, chemotherapy and radiotherapy, the prognosis of the cSCC is still unfavorable. Generally, this cancer is very aggressive and malignant, which is prone to metastasis invasion and recurrences. Therefore, it is of great significance to explore more molecules in cSCC progression and develop more novel targets for cSCC treatment.MicroRNA (miRNA) is a kind of small noncoding RNA molecules, which is highly conserved and can induce mRNA cleavage or represses gene translation via targeting the 3′UTR of corresponding mRNAs.. The dysregulation of miRNA has played a crucial role in carcinogenesis, such as lung cancer, liver cancer, gastric cancer, and cSCC. For instance, in non‐small cell lung cancer, miR‐605 can promote cell proliferation, migration, and invasion through directly inhibiting LATS2. Via targeting Bcl‐2, miR‐365 can induce cell apoptosis of hepatocellular carcinoma. In gastric cancer, miR‐944 is able to inhibit metastasis by repressing the epithelial‐mesenchymal transition (EMT) process via MACC1/Met/AKT signaling pathway. MiR‐31 can play an oncogenic

Journal

Journal of Cellular BiochemistryWiley

Published: Feb 1, 2018

Keywords: ; ; ;

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