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INTRODUCTIONGerm cell RNA granules are cytoplasmic regions, RNA‐rich and nonmembrane bound, found in germ cells across a wide range of phyla from Caenorhabditis elegans and Drosophila to mammals including mice, rats, and humans. These granules appear to be sites of crucial and complex RNA biology including small RNA processing,1 mRNA storage,2 and translation regulation.3,4 Granules are essential structures for successful spermatogenesis as loss of key granule components has catastrophic results for germ cell development and the organism's fertility.5–8 Given their importance, there has been great interest in defining the components and functions of germ cell granules, particularly in mammals.Though first observed via light microscopy as early as the late 19th century,9 a full account of germ cell granules in mammalian spermatocytes was not be conducted until nearly a century later. In 1964, Gardner employed electron microscopy (EM) to assess the seminiferous tubules of the mouse and briefly discussed the chromatoid body (CB) in spermatids.10 In 1978, six distinct granules, referred therein as “nuage,” were defined in the rat testis via EM.11 Five of these were observed primarily in spermatocytes and one, the CB, in spermatids.11 Over the subsequent decades, the field has utilized myriad models and methodologies to further
Andrology – Wiley
Published: Jul 1, 2023
Keywords: granules; male; mammalian; nuage; RNA; spermatocytes
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