Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

Mycobacterial infections in zoo animals: relevance, diagnosis and management

Mycobacterial infections in zoo animals: relevance, diagnosis and management While the world prevalence of tuberculosis (TB) is increasing in the human population, TB infection remains a real concern in some animal populations all around the globe. Most mycobacteria of the TB complex are able to infect zoo and wildlife species, in which the pathogenesis, receptivity and immune responses vary widely. The diagnostic tools usually applied in domestic animals show limited performance in zoo species, especially when prevalence is low. Conversely, investigations of cell‐mediated immunity through in vitro assay of γ‐interferon may have numerous advantages, as long as the technical limits are known and can be improved upon. Furthermore, recent tools based on the investigation of humoral immunity seem very promising for the detection of antibodies directed against certain immunogenic mycobacterial antigens in a wide range of species. All these methods are currently evaluated in field studies, despite the difficulties to ensure rigorous validation. The development of these diagnostic tools is also impaired by the prevalence of mycobacteria other than TB also able to infect and create relevant disease in their host. Thus, decisions on positive and suspicious‐animals issues should be taken based on the evaluation of the risk of transmission to the rest of the zoological collection, the possible treatment options, animal welfare, conservation considerations and, of course, the zoonotic potential of this pathogen. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Zoo Yearbook Wiley

Mycobacterial infections in zoo animals: relevance, diagnosis and management

International Zoo Yearbook , Volume 45 (1) – Jan 1, 2011

Loading next page...
 
/lp/wiley/mycobacterial-infections-in-zoo-animals-relevance-diagnosis-and-NP9NnsNKhc

References (131)

Publisher
Wiley
Copyright
© 2011 The Authors. International Zoo Yearbook © 2011 The Zoological Society of London
ISSN
0074-9664
eISSN
1748-1090
DOI
10.1111/j.1748-1090.2011.00141.x
Publisher site
See Article on Publisher Site

Abstract

While the world prevalence of tuberculosis (TB) is increasing in the human population, TB infection remains a real concern in some animal populations all around the globe. Most mycobacteria of the TB complex are able to infect zoo and wildlife species, in which the pathogenesis, receptivity and immune responses vary widely. The diagnostic tools usually applied in domestic animals show limited performance in zoo species, especially when prevalence is low. Conversely, investigations of cell‐mediated immunity through in vitro assay of γ‐interferon may have numerous advantages, as long as the technical limits are known and can be improved upon. Furthermore, recent tools based on the investigation of humoral immunity seem very promising for the detection of antibodies directed against certain immunogenic mycobacterial antigens in a wide range of species. All these methods are currently evaluated in field studies, despite the difficulties to ensure rigorous validation. The development of these diagnostic tools is also impaired by the prevalence of mycobacteria other than TB also able to infect and create relevant disease in their host. Thus, decisions on positive and suspicious‐animals issues should be taken based on the evaluation of the risk of transmission to the rest of the zoological collection, the possible treatment options, animal welfare, conservation considerations and, of course, the zoonotic potential of this pathogen.

Journal

International Zoo YearbookWiley

Published: Jan 1, 2011

There are no references for this article.