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Nutritional regulation of glucagon‐like peptide‐1 secretion

Nutritional regulation of glucagon‐like peptide‐1 secretion Glucagon‐like peptide‐1 (GLP‐1), released from L‐cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP‐1 or preventing its degradation, attention is now turning towards the L‐cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP‐1 in vivo. Understanding the mechanisms underlying GLP‐1 release from L‐cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L‐cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L‐cell nutrient responsiveness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Nutritional regulation of glucagon‐like peptide‐1 secretion

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References (51)

Publisher
Wiley
Copyright
© 2009 The Authors. Journal compilation © 2009 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.2008.164012
pmid
19001044
Publisher site
See Article on Publisher Site

Abstract

Glucagon‐like peptide‐1 (GLP‐1), released from L‐cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP‐1 or preventing its degradation, attention is now turning towards the L‐cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP‐1 in vivo. Understanding the mechanisms underlying GLP‐1 release from L‐cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L‐cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L‐cell nutrient responsiveness.

Journal

The Journal of PhysiologyWiley

Published: Jan 1, 2009

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