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Ocular manifestations of psoriasis: An inflammatory disease beyond the skin

Ocular manifestations of psoriasis: An inflammatory disease beyond the skin INTRODUCTIONPsoriasis is an immune‐mediated disorder mainly involves skin, nail, and joints. However, it can lead to several systemic complications including cardiovascular, metabolic, and psychiatric problems.1–3 Previous studies have shown some ocular manifestations in patients with psoriasis, especially those with arthropathic or pustular variants of the disease.4–6The most frequent ocular manifestations among psoriasis patients are keratoconjunctivitis sicca (dry eye syndrome), nonspecific conjunctivitis, blepharitis, cataract, and uveitis.4,6,7Ophthalmologic involvement could be due to systemic and inflammatory nature of disease as well as using some treatments such as methotrexate, acitretin, biologic drugs, and phototherapy.8,9Since ocular manifestations are often mild and nonspecific, they could be easily neglected which might be one of the explanations of wide range of their incidence rate from 10% to 58% in various studies.8,10,11Ocular manifestations in psoriatic patients have been shown to be always preceded by cutaneous lesions.12 Hence, dermatologists and general practitioners could be considered as sentinel physicians, screening patients for presentations needed further evaluations.Since some discrepancies in results of previous studies were found regarding the prevalence and also risk factors of ocular involvement in psoriasis patients, this study aimed to evaluate the incidence of various ocular manifestations in Iranian patients with psoriasis and compare it with normal population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of General and Family Medicine Wiley

Ocular manifestations of psoriasis: An inflammatory disease beyond the skin

Ocular manifestations of psoriasis: An inflammatory disease beyond the skin

Journal of General and Family Medicine , Volume 24 (1) – Jan 1, 2023

Abstract

INTRODUCTIONPsoriasis is an immune‐mediated disorder mainly involves skin, nail, and joints. However, it can lead to several systemic complications including cardiovascular, metabolic, and psychiatric problems.1–3 Previous studies have shown some ocular manifestations in patients with psoriasis, especially those with arthropathic or pustular variants of the disease.4–6The most frequent ocular manifestations among psoriasis patients are keratoconjunctivitis sicca (dry eye syndrome), nonspecific conjunctivitis, blepharitis, cataract, and uveitis.4,6,7Ophthalmologic involvement could be due to systemic and inflammatory nature of disease as well as using some treatments such as methotrexate, acitretin, biologic drugs, and phototherapy.8,9Since ocular manifestations are often mild and nonspecific, they could be easily neglected which might be one of the explanations of wide range of their incidence rate from 10% to 58% in various studies.8,10,11Ocular manifestations in psoriatic patients have been shown to be always preceded by cutaneous lesions.12 Hence, dermatologists and general practitioners could be considered as sentinel physicians, screening patients for presentations needed further evaluations.Since some discrepancies in results of previous studies were found regarding the prevalence and also risk factors of ocular involvement in psoriasis patients, this study aimed to evaluate the incidence of various ocular manifestations in Iranian patients with psoriasis and compare it with normal population.

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References (24)

Publisher
Wiley
Copyright
© 2023 Japan Primary Care Association
eISSN
2189-7948
DOI
10.1002/jgf2.576
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPsoriasis is an immune‐mediated disorder mainly involves skin, nail, and joints. However, it can lead to several systemic complications including cardiovascular, metabolic, and psychiatric problems.1–3 Previous studies have shown some ocular manifestations in patients with psoriasis, especially those with arthropathic or pustular variants of the disease.4–6The most frequent ocular manifestations among psoriasis patients are keratoconjunctivitis sicca (dry eye syndrome), nonspecific conjunctivitis, blepharitis, cataract, and uveitis.4,6,7Ophthalmologic involvement could be due to systemic and inflammatory nature of disease as well as using some treatments such as methotrexate, acitretin, biologic drugs, and phototherapy.8,9Since ocular manifestations are often mild and nonspecific, they could be easily neglected which might be one of the explanations of wide range of their incidence rate from 10% to 58% in various studies.8,10,11Ocular manifestations in psoriatic patients have been shown to be always preceded by cutaneous lesions.12 Hence, dermatologists and general practitioners could be considered as sentinel physicians, screening patients for presentations needed further evaluations.Since some discrepancies in results of previous studies were found regarding the prevalence and also risk factors of ocular involvement in psoriasis patients, this study aimed to evaluate the incidence of various ocular manifestations in Iranian patients with psoriasis and compare it with normal population.

Journal

Journal of General and Family MedicineWiley

Published: Jan 1, 2023

Keywords: dry eye syndrome; meibomian gland dysfunction; ocular manifestation; psoriasis; psoriasis area severity index

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