Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/p2rx7-a-bipolar-and-unipolar-disorder-candidate-susceptibility-gene-41q2JVqdx1
References (36)
-
A. Jones, J. Austin, N. Hansen, B. Hoogendoorn, P. Oefner, J. Cheadle, M. O’Donovan (1999)
Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis.Clinical chemistry, 45 8 Pt 1
-
N. Craddock, I. Jones, G. Kirov, L. Jones (2004)
The Bipolar Affective Disorder Dimension Scale (BADDS) – a dimensional scale for rating lifetime psychopathology in Bipolar spectrum disordersBMC Psychiatry, 4
-
J. Austin, P. Buckland, A. Cardno, N. Williams, G. Spurlock, B. Hoogendoorn, S. Zammit, G. Jones, R. Sanders, L. Jones, G. McCarthy, Susan Jones, N. Bray, P. McGuffin, M. Owen, M. O’Donovan (2000)
The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophreniaMolecular Psychiatry, 5
-
K. Héjjas, A. Székely, E. Domotor, Z. Halmai, G. Balogh, Boglarka Schilling, A. Sárosi, G. Faludi, M. Sasvári‐Székely, Z. Nemoda (2009)
Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approachAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B
-
F. Dudbridge (2003)
Pedigree disequilibrium tests for multilocus haplotypesGenetic Epidemiology, 25
-
P. Sham, A. Sterne, S. Purcell, S. Cherny, M. Webster, F. Rijsdijk, P. Asherson, D. Ball, I. Craig, T. Eley, D. Goldberg, J. Gray, A. Mann, M. Owen, R. Plomin (2000)
GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings.Twin research : the official journal of the International Society for Twin Studies, 3 4
-
A. McQuillin, N. Bass, K. Choudhury, V. Puri, M. Kosmin, J. Lawrence, David Curtis, H. Gurling (2009)
Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disordersMolecular Psychiatry, 14
-
G. Zubenko, B. Maher, H. Hughes, W. Zubenko, J. Stiffler, B. Kaplan, M. Marazita (2003)
Genome‐wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early‐onset, major depressionAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 123B
-
D. Curtis, G. Kalsi, J. Brynjólfsson, M. McInnis, J. O'Neill, C. Smyth, E. Moloney, P. Murphy, A. McQuillin, H. Pétursson, H. Gurling (2003)
Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23‐q24, and suggests the presence of additional loci on 1p and 1qPsychiatric Genetics, 13
-
P. McGuffin, A. Farmer, I. Harvey (1991)
A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system.Archives of general psychiatry, 48 8
-
S. Gabriel, S. Schaffner, Huy Nguyen, Jamie Moore, J. Roy, B. Blumenstiel, J. Higgins, M. Defelice, Amy Lochner, M. Faggart, S. Liu-Cordero, C. Rotimi, A. Adeyemo, R. Cooper, R. Ward, E. Lander, M. Daly, D. Altshuler (2002)
The Structure of Haplotype Blocks in the Human GenomeScience, 296
-
J. Barrett, B. Fry, J. Maller, M. Daly (2005)
Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 21 2
-
J. Ekholm, T. Kieseppä, T. Hiekkalinna, T. Partonen, T. Paunio, M. Perola, J. Ekelund, J. Lönnqvist, Petra Pekkarinen-Ijäs, L. Peltonen (2003)
Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder.Human molecular genetics, 12 15
-
B. Degn, M. Lundorf, A. Wang, M. Vang, O. Mors, T. Kruse, H. Ewald (2001)
Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe IslandsMolecular Psychiatry, 6
-
M. Maziade, M. Roy, E. Rouillard, L. Bissonnette, J. Fournier, A. Roy, Y. Garneau, N. Montgrain, A. Potvin, D. Cliche, C. Dion, H. Wallot, A. Fournier, L. Nicole, J. Lavallée, C. Mérette (2001)
A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomesMolecular Psychiatry, 6
-
N. Barden, M. Harvey, B. Gagné, E. Shink, M. Tremblay, C. Raymond, M. Labbé, A. Villeneuve, Denis Rochette, Lise Bordeleau, H. Stadler, F. Holsboer, B. Müller-Myhsok (2006)
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorderAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B
-
J. Wendland, F. McMahon (2011)
Genetics of bipolar disorder.Current topics in behavioral neurosciences, 5
-
E. Green, G. Elvidge, N. Jacobsen, B. Glaser, I. Jones, M. O’Donovan, G. Kirov, M. Owen, N. Craddock (2005)
Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease.The American journal of psychiatry, 162 1
-
J. Leckman, D. Sholomskas, Douglas Thompson, Arthur Belanger, Myrna Weissman (1982)
Best estimate of lifetime psychiatric diagnosis: a methodological study.Archives of general psychiatry, 39 8
-
E. Shink, J. Morissette, R. Sherrington, N. Barden (2005)
A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12Molecular Psychiatry, 10
-
E. Dawson, E. Parfitt, Queta Roberts, J. Daniels, Lionel Lim, Pak Sham, M. Nöthen, P. Propping, M. Lanczik, Wolfgang Maier, Ulrike Reuner, Jean Weissenbach, Michael Gill, John Powell, P. McGuffin, M. Owen, N. Craddock, N. Craddock (1995)
Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1.American journal of medical genetics, 60 2
-
J. Morissette, A. Villeneuve, Lise Bordeleau, Denis Rochette, C. Laberge, B. Gagné, C. Laprise, G. Bouchard, M. Plante, L. Gobeil, E. Shink, J. Weissenbach, N. Barden (1999)
Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24.American journal of medical genetics, 88 5
-
N. Craddock, M. Owen, S. Burge, Bobby Kurian, Phil Thomas, P. McGuffin (1994)
Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)British Journal of Psychiatry, 164
-
V. Abkevich, N. Camp, C. Hensel, C. Neff, Deanna Russell, Dana Hughes, Agnes Plenk, M. Lowry, R. Richards, C. Carter, G. Frech, S. Stone, K. Rowe, C. Chau, Kathleen Cortado, Angelene Hunt, Karanina Luce, G. O'Neil, J. Poarch, J. Potter, Gregg Poulsen, H. Saxton, Michelle Bernat-Sestak, Victor Thompson, A. Gutin, M. Skolnick, D. Shattuck, L. Cannon-Albright (2003)
Predisposition locus for major depression at chromosome 12q22-12q23.2.American journal of human genetics, 73 6
-
Ian Jones, N. Jacobsen, E. Green, G. Elvidge, M. Owen, N. Craddock (2002)
Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's diseaseMolecular Psychiatry, 7
-
V. Mittal, E. Walker (2011)
Diagnostic and Statistical Manual of Mental DisordersPsychiatry Research, 189
-
S. Lucae, D. Salyakina, N. Barden, M. Harvey, B. Gagné, M. Labbé, E. Binder, M. Uhr, M. Páez-Pereda, I. Sillaber, M. Ising, T. Brückl, R. Lieb, F. Holsboer, B. Müller-Myhsok (2006)
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.Human molecular genetics, 15 16
-
G. Kirov, J. Tredget (2005)
Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case seriesBMC Psychiatry, 5
-
H. Ewald, B. Degn, O. Mors, T. Kruse (1998)
Significant linkage between bipolar affective disorder and chromosome 12q24Psychiatric Genetics, 8
-
V. Moskvina, P. Holmans, Karl Schmidt, N. Craddock (2005)
Design of Case‐controls Studies with Unscreened ControlsAnnals of Human Genetics, 69
-
P. McGuffin, J. Knight, G. Breen, S. Brewster, P. Boyd, N. Craddock, M. Gill, A. Korszun, W. Maier, L. Middleton, O. Mors, M. Owen, J. Perry, M. Preisig, T. Reich, J. Rice, M. Rietschel, L. Jones, P. Sham, A. Farmer (2005)
Whole genome linkage scan of recurrent depressive disorder from the depression network study.Human molecular genetics, 14 22
-
M. Owen, Peter Holmans, P. McGuffin (1997)
Association studies in psychiatric geneticsMolecular Psychiatry, 2
-
P. McGuffin, R. Katz (1989)
The Genetics of Depression and Manic-Depressive DisorderBritish Journal of Psychiatry, 155
-
J. Wing, T. Babor, T. Brugha, J. Burke, J. Cooper, R. Giel, A. Jablenski, D. Regier, N. Sartorius (1990)
SCAN. Schedules for Clinical Assessment in Neuropsychiatry.Archives of general psychiatry, 47 6
-
(1999)
Automated optimal temperature selection for denaturing high performance liquid chromatography -
N. Craddock, L. Forty (2006)
Genetics of affective (mood) disordersEuropean Journal of Human Genetics, 14
- Publisher
- Wiley
- Copyright
- Copyright © 2009 Wiley‐Liss, Inc., A Wiley Company
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- DOI
- 10.1002/ajmg.b.30931
- pmid
- 19160446
- Publisher site
- See Article on Publisher Site
Abstract
The chromosomal region 12q24 has been previously implicated by linkage studies of both bipolar disorder and unipolar mood disorder and we have reported two pedigrees segregating both bipolar disorder and Darier's disease that show linkage across this region. The gene P2RX7 is located in this chromosomal region and has been recently reported as a susceptibility gene for bipolar disorder and unipolar depression. The non‐synonymous SNP rs2230912 (resulting in amino‐acid polymorphism Q460R) showed the strongest association and has been postulated to be pathogenically relevant. We have investigated this gene in a large UK case‐control sample (bipolar I disorder N = 687, unipolar recurrent major depression N = 1,036, controls N = 1,204). Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder. Further, sequencing of our two chromosome 12‐linked bipolar‐Darier families showed no evidence of rare variants at P2RX7 that could explain the linkage. Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders. © 2009 Wiley‐Liss, Inc.
Journal
American Journal of Medical Genetics part B – Wiley
Published: Dec 5, 2009
Keywords: P2RX7 ; bipolar disorder; unipolar disorder; case–control study