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Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis

Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis INTRODUCTIONAllergic rhinitis (AR) is a common allergic disease in both Japan and the West. In Japan, perennial AR is often caused by mites, whereas seasonal AR is typically caused by Japanese cedar pollen. Japanese cedar pollen‐induced AR (JCP‐AR) prompts intense nasal symptoms from February to April and affects up to one‐third of the whole Japanese population. With the number of afflicted people increasing each year, it is posing immense social problems. Thus, in addition to studies on normal therapeutic treatment, research is being conducted to establish methods to prevent sensitization to JCP and the occurrence of the disease. However, given the abundance of Japanese cedar pollen, allergen avoidance as a primary prophylactic measure against JCP‐AR is not a realistic option. Although experiments involving the oral administration of probiotics are also being conducted, they have yet to yield satisfactory results.Not everyone who is sensitized to the allergen develops AR: a stage called asymptomatic sensitization (AS) occurs before the onset. In other words, type I allergic diseases consist of three stages of development that depend on the presence/absence of antigen‐specific IgE and symptoms: (i) the non–antigen‐sensitized stage, (ii) the sensitized but barely symptomatic stage, and (iii) the symptomatic stage. Although researchers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergy Wiley

Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis

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References (40)

Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0105-4538
eISSN
1398-9995
DOI
10.1111/all.13295
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONAllergic rhinitis (AR) is a common allergic disease in both Japan and the West. In Japan, perennial AR is often caused by mites, whereas seasonal AR is typically caused by Japanese cedar pollen. Japanese cedar pollen‐induced AR (JCP‐AR) prompts intense nasal symptoms from February to April and affects up to one‐third of the whole Japanese population. With the number of afflicted people increasing each year, it is posing immense social problems. Thus, in addition to studies on normal therapeutic treatment, research is being conducted to establish methods to prevent sensitization to JCP and the occurrence of the disease. However, given the abundance of Japanese cedar pollen, allergen avoidance as a primary prophylactic measure against JCP‐AR is not a realistic option. Although experiments involving the oral administration of probiotics are also being conducted, they have yet to yield satisfactory results.Not everyone who is sensitized to the allergen develops AR: a stage called asymptomatic sensitization (AS) occurs before the onset. In other words, type I allergic diseases consist of three stages of development that depend on the presence/absence of antigen‐specific IgE and symptoms: (i) the non–antigen‐sensitized stage, (ii) the sensitized but barely symptomatic stage, and (iii) the symptomatic stage. Although researchers

Journal

AllergyWiley

Published: Jan 1, 2018

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