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Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their function

Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their... INTRODUCTIONHCC is the most common malignancy of liver and causes a major health problem for a long time (Jemal et al., ). Clinical treatments, such as liver transplantation and resection represent the most curative therapy for HCC patients at an early stage. However, the prognosis after curative therapy for HCC always remained unsatisfactory because of a high incidence of postoperative recurrence rate (Poon, ; Zimmerman et al., ). Indeed, HCC is the second cause of cancer‐related death all over the world, whether in rich developed countries (Qatar) or poor developing countries (Congo) (Llovet et al., ). Furthermore, HCC has ranked to the highest rates due to cancer in Asia and Middle Africa and the average age of death is much lower than that cardiovascular diseases for decades. Interestingly, the occurrence of HCC was more frequent among males (Jemal et al., ). Therefore, HCC is becoming a severe social problem affecting human health. Moreover, the major risk factors of HCC include hepatitis C (HCV) and B virus (HBV) infection, toxins, chronic alcohol abuse, nonalcoholic fatty liver disease and etc. (Levrero, ). Despite new advanced therapeutic were continuously carried out in the last few years, the survival rate of HCC is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular Physiology Wiley

Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their function

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References (139)

Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0021-9541
eISSN
1097-4652
DOI
10.1002/jcp.26154
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHCC is the most common malignancy of liver and causes a major health problem for a long time (Jemal et al., ). Clinical treatments, such as liver transplantation and resection represent the most curative therapy for HCC patients at an early stage. However, the prognosis after curative therapy for HCC always remained unsatisfactory because of a high incidence of postoperative recurrence rate (Poon, ; Zimmerman et al., ). Indeed, HCC is the second cause of cancer‐related death all over the world, whether in rich developed countries (Qatar) or poor developing countries (Congo) (Llovet et al., ). Furthermore, HCC has ranked to the highest rates due to cancer in Asia and Middle Africa and the average age of death is much lower than that cardiovascular diseases for decades. Interestingly, the occurrence of HCC was more frequent among males (Jemal et al., ). Therefore, HCC is becoming a severe social problem affecting human health. Moreover, the major risk factors of HCC include hepatitis C (HCV) and B virus (HBV) infection, toxins, chronic alcohol abuse, nonalcoholic fatty liver disease and etc. (Levrero, ). Despite new advanced therapeutic were continuously carried out in the last few years, the survival rate of HCC is

Journal

Journal of Cellular PhysiologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

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