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Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene

Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced... Correspondence Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene Proliferation centres (PC) are the histological hallmark of paraffin-embedded (FFPE) tissue sections from 54 lymph chronic lymphocytic leukaemia/small lymphocytic lymphoma nodes of CLL/SLL patients using an automated immunos- (CLL/SLL), and are thought to be important sites of B-cell tainer (Ventana Benchmark Ultra, Ventana Medical Systems). receptor (BCR) signalling, driving cell proliferation (Steven- None of the analysed lymph nodes were from patients receiv- son et al, 2011; Krysov et al, 2012). A major downstream tar- ing Bruton tyrosine kinase or phosphatidylinositol 3-kinase get of BCR signalling, at least partly via MEK1/2-ERK1/2, is inhibitors. The proportion of MYC-positive cells was esti- the MYC proto-oncogene, which regulates a variety of pro- mated in the 3 PC with greatest staining and in the sur- rounding lymphoma as <5%, 5–10%, >10–25%, >25–50% teins and microRNAs controlling cell cycle entry and cell growth (Stevenson et al, 2011; Dang, 2012; Krysov et al, and >50%. FICTION analysis was performed on 11 cases. 2012). MYC is expressed in various lymphomas due to rear- Briefly, FFPE tissue slides were incubated with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Haematology Wiley

Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene

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References (11)

Publisher
Wiley
Copyright
Copyright © 2016 John Wiley & Sons Ltd
ISSN
0007-1048
eISSN
1365-2141
DOI
10.1111/bjh.13844
pmid
26568397
Publisher site
See Article on Publisher Site

Abstract

Correspondence Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene Proliferation centres (PC) are the histological hallmark of paraffin-embedded (FFPE) tissue sections from 54 lymph chronic lymphocytic leukaemia/small lymphocytic lymphoma nodes of CLL/SLL patients using an automated immunos- (CLL/SLL), and are thought to be important sites of B-cell tainer (Ventana Benchmark Ultra, Ventana Medical Systems). receptor (BCR) signalling, driving cell proliferation (Steven- None of the analysed lymph nodes were from patients receiv- son et al, 2011; Krysov et al, 2012). A major downstream tar- ing Bruton tyrosine kinase or phosphatidylinositol 3-kinase get of BCR signalling, at least partly via MEK1/2-ERK1/2, is inhibitors. The proportion of MYC-positive cells was esti- the MYC proto-oncogene, which regulates a variety of pro- mated in the 3 PC with greatest staining and in the sur- rounding lymphoma as <5%, 5–10%, >10–25%, >25–50% teins and microRNAs controlling cell cycle entry and cell growth (Stevenson et al, 2011; Dang, 2012; Krysov et al, and >50%. FICTION analysis was performed on 11 cases. 2012). MYC is expressed in various lymphomas due to rear- Briefly, FFPE tissue slides were incubated with

Journal

British Journal of HaematologyWiley

Published: Oct 1, 2016

Keywords: ; ; ; ;

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