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Risk factors for Kaposi's‐sarcoma‐associated herpesvirus (KSHV/HHV‐8) seropositivity in a cohort of homosexual men, 1981–1996

Risk factors for Kaposi's‐sarcoma‐associated herpesvirus (KSHV/HHV‐8) seropositivity in a cohort... A newly identified herpesvirus has been associated with Kaposi's sarcoma. We determined risk factors for Kaposi's‐sarcoma‐associated herpesvirus/human herpesvirus 8 (KSHV/HHV‐8) seropositivity and incidence of infection over time in a cohort of Danish homosexual men followed from 1981 to 1996. Antibodies to a latent nuclear (LANA) and a structural (orf65) antigen of KSHV/HHV‐8 were measured by immunofluorescence and ELISA/WB respectively. Through linkage with the national AIDS registry, all cohort members diagnosed with AIDS as of September 1996 were identified and their hospital records were scrutinized to record all diagnoses of KS. Overall, 21.1% (52/246) of the men were KSHV/HHV‐8‐seropositive in 1981. Among the initially seronegative, the rate of KSHV/HHV‐8 seroconversion was highest between 1981 and 1982 and declined steadily thereafter. In a multivariate analysis of the status at enrollment in 1981, KSHV/HHV‐8 seropositivity was not associated with age but was independently associated both with number of receptive anal intercourses (OR = 2.83; p = 0.03) and with sex with US men (OR = 2.27; p < 0.05). In a multivariate analysis of follow‐up data, risk of KSHV/HHV‐8 seroconversion was independently associated with having visited homosexual communities in the United States, and current HIV‐positive status. More than 5 years' homosexual experience was associated with an insignificantly increased risk (RR = 2.68). KS occurred only in HIV‐positive men who were KSHV/HHV‐8‐positive at or prior to their KS diagnosis. In conclusion, KSHV/HHV‐8 appears to be sexually transmitted, probably by receptive anal intercourse, and may have been introduced to Danish homosexual men via sex with US men. The epidemic of KSHV/HHV‐8 is now declining. These findings are concordant with the view that KSHV/HHV‐8 may have been actively spread simultaneously with and by the same activities that lead to the spread of HIV. Int. J. Cancer 77:543–548, 1998. © 1998 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Cancer Wiley

Risk factors for Kaposi's‐sarcoma‐associated herpesvirus (KSHV/HHV‐8) seropositivity in a cohort of homosexual men, 1981–1996

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References (33)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services
ISSN
0020-7136
eISSN
1097-0215
DOI
10.1002/(SICI)1097-0215(19980812)77:4<543::AID-IJC12>3.0.CO;2-7
Publisher site
See Article on Publisher Site

Abstract

A newly identified herpesvirus has been associated with Kaposi's sarcoma. We determined risk factors for Kaposi's‐sarcoma‐associated herpesvirus/human herpesvirus 8 (KSHV/HHV‐8) seropositivity and incidence of infection over time in a cohort of Danish homosexual men followed from 1981 to 1996. Antibodies to a latent nuclear (LANA) and a structural (orf65) antigen of KSHV/HHV‐8 were measured by immunofluorescence and ELISA/WB respectively. Through linkage with the national AIDS registry, all cohort members diagnosed with AIDS as of September 1996 were identified and their hospital records were scrutinized to record all diagnoses of KS. Overall, 21.1% (52/246) of the men were KSHV/HHV‐8‐seropositive in 1981. Among the initially seronegative, the rate of KSHV/HHV‐8 seroconversion was highest between 1981 and 1982 and declined steadily thereafter. In a multivariate analysis of the status at enrollment in 1981, KSHV/HHV‐8 seropositivity was not associated with age but was independently associated both with number of receptive anal intercourses (OR = 2.83; p = 0.03) and with sex with US men (OR = 2.27; p < 0.05). In a multivariate analysis of follow‐up data, risk of KSHV/HHV‐8 seroconversion was independently associated with having visited homosexual communities in the United States, and current HIV‐positive status. More than 5 years' homosexual experience was associated with an insignificantly increased risk (RR = 2.68). KS occurred only in HIV‐positive men who were KSHV/HHV‐8‐positive at or prior to their KS diagnosis. In conclusion, KSHV/HHV‐8 appears to be sexually transmitted, probably by receptive anal intercourse, and may have been introduced to Danish homosexual men via sex with US men. The epidemic of KSHV/HHV‐8 is now declining. These findings are concordant with the view that KSHV/HHV‐8 may have been actively spread simultaneously with and by the same activities that lead to the spread of HIV. Int. J. Cancer 77:543–548, 1998. © 1998 Wiley‐Liss, Inc.

Journal

International Journal of CancerWiley

Published: Jan 12, 1998

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