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Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway

Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and... INTRODUCTIONGastric cancer, the second most common cause of cancer‐related mortalities in worldwide, has remained a major life‐threatening disease for a long time. Its incidence and mortality rates are approximately 6.8% and 8.8%, respectively, in all malignancies. Although the incidence and mortality rates have been substantially falling in certain regions, the 5‐year survival rate of gastric cancer is still no more than 25%. As a prevalent, yet heterogeneous disease, gastric cancer is considered as a complex illness with multiple reasons, including diet, lifestyle, genetics, and even infections with Helicobacter pylori. Though recent reports suggest that the mortality rate of gastric cancer has declined, the prognosis and survival rate is still poor. Therefore, an alternative therapeutic approach to gastric cancer remains a necessity.Collagen type I alpha 2 (COL1A2), which encodes the pro‐alpha 2 chain of type I collagen, is a key gene in a 37‐gene network that modulates cell motility through interaction with the cytoskeleton. It is noted that COL1A2 is differentially expressed in gastric cancer by complementary DNA (cDNA) microarray. Thrombospondin 2 (THBS2), a member of the matricellular Ca2+‐binding glycoproteins family, has been observed to interact with multiple cell receptors, growth factors, and extracellular matrix (ECM) proteins, which lead to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cellular Biochemistry Wiley

Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k‐Akt signaling pathway

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References (44)

Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0730-2312
eISSN
1097-4644
DOI
10.1002/jcb.26524
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONGastric cancer, the second most common cause of cancer‐related mortalities in worldwide, has remained a major life‐threatening disease for a long time. Its incidence and mortality rates are approximately 6.8% and 8.8%, respectively, in all malignancies. Although the incidence and mortality rates have been substantially falling in certain regions, the 5‐year survival rate of gastric cancer is still no more than 25%. As a prevalent, yet heterogeneous disease, gastric cancer is considered as a complex illness with multiple reasons, including diet, lifestyle, genetics, and even infections with Helicobacter pylori. Though recent reports suggest that the mortality rate of gastric cancer has declined, the prognosis and survival rate is still poor. Therefore, an alternative therapeutic approach to gastric cancer remains a necessity.Collagen type I alpha 2 (COL1A2), which encodes the pro‐alpha 2 chain of type I collagen, is a key gene in a 37‐gene network that modulates cell motility through interaction with the cytoskeleton. It is noted that COL1A2 is differentially expressed in gastric cancer by complementary DNA (cDNA) microarray. Thrombospondin 2 (THBS2), a member of the matricellular Ca2+‐binding glycoproteins family, has been observed to interact with multiple cell receptors, growth factors, and extracellular matrix (ECM) proteins, which lead to

Journal

Journal of Cellular BiochemistryWiley

Published: Jun 1, 2018

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