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Special focus: Phages and viruses

Special focus: Phages and viruses With this special focus on viruses and phages and their impact on different ecosystems, we hope to contribute to the rising interest in viral ecology. In the early days of molecular genetics, the main focus was on bacteriophages as easy amenable systems to develop molecular biology toolkits. During the golden era of antibiotics, phages were somewhat less prominent in research. Due to the antibiotics crisis now, with increasing multi‐resistant bacterial pathogens arising, a renewed interest in phage biology including the potential application of bacteriophages in phage therapy ensues. With respect to phages, this issue consequently includes the analysis of phages infecting (multi)resistant bacterial pathogens like a bacteriophage isolated and characterized for its potential to be used against shigatoxigenic Escherichia coli (Inbarai et al., this issue) or a phage infecting Vibrio cholerae (Maina at al., this issue).The arms race between evolution of phages and their hosts is investigated in another contribution where the authors used transposon‐based mutagenesis to investigate the molecular basis of phage resistance in Salmonella enterica (Wang et al., this issue).On the viral side, viruses infecting humans may cause severe and hard‐to‐treat disease, as we painfully learned with the Corona pandemic. Dengue fever is causing potentially life‐threatening infections with hemorrhagic fever and liver dysfunction, especially in the tropics. Here, early diagnosis is in urgent need, and a protein could be characterized by Munir et al. that may pose a target for developing diagnostic tools (Munir et al., this issue).A better molecular and basic understanding of viral infection also includes viral evolution. Albeit the long use of phages for genetic studies, including the early days of molecular biology development, still viral codon use or nucleotide bias are providing new insights for phage/viral evolution. Here, the zoonotic African swine fever virus was used in a comparative genomics analysis (Pu et al., this issue). On the same line of investigations on evolutionary adaptation, another article tackles bovine coronavirus (BCoV) to identify recombination on a viral genome level (Bahoussi et al., this issue).We hope you enjoy our current article collection the special issue on phages and viruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Basic Microbiology Wiley

Special focus: Phages and viruses

Kothe, Erika
Journal of Basic Microbiology , Volume 63 (5) – May 1, 2023
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Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH.
ISSN
0233-111X
eISSN
1521-4028
DOI
10.1002/jobm.202300136
Publisher site
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Abstract

With this special focus on viruses and phages and their impact on different ecosystems, we hope to contribute to the rising interest in viral ecology. In the early days of molecular genetics, the main focus was on bacteriophages as easy amenable systems to develop molecular biology toolkits. During the golden era of antibiotics, phages were somewhat less prominent in research. Due to the antibiotics crisis now, with increasing multi‐resistant bacterial pathogens arising, a renewed interest in phage biology including the potential application of bacteriophages in phage therapy ensues. With respect to phages, this issue consequently includes the analysis of phages infecting (multi)resistant bacterial pathogens like a bacteriophage isolated and characterized for its potential to be used against shigatoxigenic Escherichia coli (Inbarai et al., this issue) or a phage infecting Vibrio cholerae (Maina at al., this issue).The arms race between evolution of phages and their hosts is investigated in another contribution where the authors used transposon‐based mutagenesis to investigate the molecular basis of phage resistance in Salmonella enterica (Wang et al., this issue).On the viral side, viruses infecting humans may cause severe and hard‐to‐treat disease, as we painfully learned with the Corona pandemic. Dengue fever is causing potentially life‐threatening infections with hemorrhagic fever and liver dysfunction, especially in the tropics. Here, early diagnosis is in urgent need, and a protein could be characterized by Munir et al. that may pose a target for developing diagnostic tools (Munir et al., this issue).A better molecular and basic understanding of viral infection also includes viral evolution. Albeit the long use of phages for genetic studies, including the early days of molecular biology development, still viral codon use or nucleotide bias are providing new insights for phage/viral evolution. Here, the zoonotic African swine fever virus was used in a comparative genomics analysis (Pu et al., this issue). On the same line of investigations on evolutionary adaptation, another article tackles bovine coronavirus (BCoV) to identify recombination on a viral genome level (Bahoussi et al., this issue).We hope you enjoy our current article collection the special issue on phages and viruses.

Journal

Journal of Basic Microbiology – Wiley

Published: May 1, 2023

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