Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Noble-Topham, M. Cader, D. Dyment, G. Rice, J. Brown, G. Ebers (2003)Genetic loading in familial migraine with aura
Journal of Neurology, Neurosurgery & Psychiatry, 74
Anna Carlsson, L. Forsgren, P. Nylander, U. Hellman, K. Forsman‐Semb, G. Holmgren, D. Holmberg, M. Holmberg (2002)Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1
David Gordon, C. Abajian, P. Green (1998)Consed: a graphical tool for sequence finishing.
Genome research, 8 3
G. Terwindt, R. Ophoff, R. Eijk, M. Vergouwe, J. Haan, R. Frants, L. Sandkuijl, M. Ferrari (2001)Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura
A. Ducros, C. Denier, A. Joutel, K. Vahedi, A. Michel, F. Darcel, M. Madigand, D. Guerouaou, F. Tison, J. Julien, E. Hirsch, F. Chédru, C. Bisgård, G. Lucotte, P. Desprès, C. Billard, M. Barthez, G. Ponsot, M. Bousser, E. Tournier-Lasserve (1999)Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia.
American journal of human genetics, 64 1
Gardner (2004)A two-locus FHM2 family with unique ATP1A2 mutation and comparative study in C.elegans showing regulation of tryptophan hydroxylase by EAT-6 and UNC-2, the orthologous FHM2 and FHM1 genes
Z. Cader, S. Noble-Topham, D. Dyment, S. Cherny, John Brown, G. Rice, G. Ebers (2003)Significant linkage to migraine with aura on chromosome 11q24.
Human molecular genetics, 12 19
R. Lea, R. Curtain, C. Hutchins, P. Brimage, L. Griffiths (2001)Investigation of the CACNA1A gene as a candidate for typical migraine susceptibility.
American journal of medical genetics, 105 8
Ji-Soo Kim, Q. Yue, Joanna Jen, Stanley Nelson, R. Baloh (1998)Familial migraine with vertigo: no mutations found in CACNA1A.
American journal of medical genetics, 79 2
E. Kors, A. Melberg, K. Vanmolkot, Eva Kumlien, J. Haan, Raili Raininko, Roland Flink, H. Ginjaar, Rune Frants, M. Ferrari, Am Maagdenberg (2004)Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation
M. Russell, B. Rasmussen, P. Thorvaldsen, Jes Olesen (1995)Prevalence and sex-ratio of the subtypes of migraine.
International journal of epidemiology, 24 3
I. Alonso, J. Barros, A. Tuna, J. Coelho, J. Sequeiros, I. Silveira, P. Coutinho (2003)Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family.
Archives of neurology, 60 4
M. Russell, Jes Olesen (1995)Increased familial risk and evidence of genetic factor in migraine
V. Ulrich, M. Gervil, K. Kyvik, J. Olesen, M. Russell (1999)Evidence of a genetic factor in migraine with aura: A population‐based Danish twin study
Annals of Neurology, 45
R. Lea, Graeme Shepherd, R. Curtain, D. Nyholt, S. Quinlan, P. Brimage, L. Griffiths (2002)A typical migraine susceptibility region localizes to chromosome 1q31
G. Terwindt, E. Kors, J. Haan, F. Vermeulen, A. Maagdenberg, R. Frants, M. Ferrari (2002)Mutation Analysis of the CACNA1A Calcium Channel Subunit Gene in 27 Patients With Sporadic Hemiplegic Migraine
JAMA Neurology, 59
I. Hovatta, M. Kallela, M. Färkkilä, Leena Peltonen (1994)Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p.
Genomics, 23 3
S. Rozen, H. Skaletsky (2000)Primer3 on the WWW for general users and for biologist programmers.
Methods in molecular biology, 132
(2003)Systematic analysis of the familial hemiplegic migraine gene ATP1A2 in migraine with aura
T. Wada, N. Kobayashi, Yoshio Takahashi, T. Aoki, Takako Watanabe, S. Saitoh (2002)Wide clinical variability in a family with a CACNA1A T666m mutation: hemiplegic migraine, coma, and progressive ataxia.
Pediatric neurology, 26 1
D. Pietrobon (2002)Calcium channels and channelopathies of the central nervous system
Molecular Neurobiology, 25
(1998)Approaches to genemapping in complex human diseases
K. Jones, M. Ehm, M. Pericak-Vance, J. Haines, P. Boyd, S. Peroutka (2001)Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus.
Genomics, 78 3
R. Brugnoni, Massimo Leone, A. Rigamonti, E. Moranduzzo, Ferdinando Cornelio, Renato Mantegazza, G. Bussone (2002)Is the CACNA1A gene involved in familial migraine with aura?
Neurological Sciences, 23
(1997)onmigrainepatients: Exclusion of mutations in CACNA1A4 gene
M. Spadaro, S. Ursu, F. Lehmann-Horn, V. Liana, Antonini Giovanni, Giunti Paola, M. Frontali, K. Jurkat-Rott (2004)A G301R Na+/K+-ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs
D. Soragna, A. Vettori, Gianni Carraro, E. Marchioni, G. Vazza, S. Bellini, R. Tupler, R. Tupler, F. Savoldi, M. Mostacciuolo (2003)A locus for migraine without aura maps on chromosome 14q21.2-q22.3.
American journal of human genetics, 72 1
L. Thomsen, J. Olesen, Megan Russell (2003)Increased risk of migraine with typical aura in probands with familial hemiplegic migraine and their relatives
European Journal of Neurology, 10
R. Ophoff, G. Terwindt, M. Vergouwe, R. Eijk, P. Oefner, S. Hoffman, J. Lamerdin, H. Mohrenweiser, D. Bulman, M. Ferrari, J. Haan, D. Lindhout, G. Ommen, M. Hofker, M. Ferrari, R. Frants (1996)Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
A. Kong, D. Gudbjartsson, J. Sainz, G. Jónsdóttir, S. Gudjonsson, Bjorgvin Richardsson, Sigrun Sigurdardóttir, J. Barnard, B. Hallbeck, G. Másson, A. Shlien, Stefan Palsson, M. Frigge, T. Thorgeirsson, J. Gulcher, K. Stefánsson (2002)A high-resolution recombination map of the human genome
Nature Genetics, 31
E. Kors, G. Terwindt, F. Vermeulen, R. Fitzsimons, P. Jardine, P. Heywood, S. Love, A. Maagdenberg, J. Haan, R. Frants, M. Ferrari (2001)Delayed cerebral edema and fatal coma after minor head trauma: Role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine
Annals of Neurology, 49
V. Ulrich, M. Gervil, K. Kyvik, Jes Olesen, M. Russell (1999)The inheritance of migraine with aura estimated by means of structural equation modelling
Journal of Medical Genetics, 36
G. Terwindt, R. Ophoff, J. Haan, M. Vergouwe, R. Eijk, R. Frants, M. Ferrari (1998)Variable clinical expression of mutations in the P/Q-type calcium channel gene in familial hemiplegic migraine
R. Lea, D. Nyholt, R. Curtain, M. Ovcaric, R. Sciascia, C. Bellis, J. MacMillan, S. Quinlan, R. Gibson, L. McCarthy, J. Riley, Y. Smithies, S. Kinrade, L. Griffiths (2005)A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine
T. Wieser, C. Mueller, S. Evers, S. Zierz, T. Deufel (2003)Absence of Known Familial Hemiplegic Migraine (FHM) Mutations in the CACNA1A Gene in Patients with common Migraine: Implications for Genetic Testing
I. Alonso, J. Barros, A. Tuna, A. Seixas, P. Coutinho, J. Sequeiros, I. Silveira (2003)A novel R1347Q mutation in the predicted voltage sensor segment of the P/Q‐type calcium‐channel α1A‐subunit in a family with progressive cerebellar ataxia and hemiplegic migraine
Clinical Genetics, 65
D. Nyholt, R. Lea, P. Goadsby, P. Brimage, L. Griffiths (1998)Familial typical migraine
M. Russell, L. Iselius, J. Olesen (1995)Inheritance of migraine investigated by complex segregation analysis
Human Genetics, 96
M. Kaunisto, Päivi Tikka, M. Kallela, S. Leal, J. Papp, Arja Korhonen, E. Hämäläinen, H. Harno, H. Havanka, M. Nissilä, E. Säkö, M. Ilmavirta, J. Kaprio, M. Färkkilä, R. Ophoff, A. Palotie, M. Wessman (2005)Chromosome 19p13 loci in Finnish migraine with aura families
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 132B
P. Goadsby (2004)A Report on the Journal 2004
R. Fossdal, F. Jónasson, G. Kristjansdottir, A. Kong, H. Stefánsson, S. Gosh, J. Gulcher, K. Stefánsson (2004)A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration).
Human molecular genetics, 13 9
V. Ulrich, M. Russell, S. Ostergaard, J. Olesen (1997)Analysis of 31 families with an apparently autosomal-dominant transmission of migraine with aura in the nuclear family.
American journal of medical genetics, 74 4
M. Fusco, R. Marconi, L. Silvestri, L. Atorino, L. Rampoldi, L. Morgante, A. Ballabio, P. Aridon, G. Casari (2003)Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump α2 subunit associated with familial hemiplegic migraine type 2
Nature Genetics, 33
K. Jurkat-Rott, T. Freilinger, J. Dreier, Jürgen Herzog, H. Göbel, G. Petzold, P. Montagna, T. Gasser, F. Lehmann‐Horn, M. Dichgans (2004)Variability of familial hemiplegic migraine with novel A1A2 Na+/K+-ATPase variants
L. Russo, P. Mariotti, E. Sangiorgi, T. Giordano, I. Ricci, F. Lupi, Rossella Chiera, F. Guzzetta, G. Neri, F. Gurrieri (2005)A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes.
American journal of human genetics, 76 2
E. Kors, J. Haan, N. Giffin, L. Pazdera, C. Schnittger, G. Lennox, G. Terwindt, F. Vermeulen, A. Maagdenberg, R. Frants, M. Ferrari (2003)Expanding the phenotypic spectrum of the CACNA1A gene T666M mutation: a description of 5 families with familial hemiplegic migraine.
Archives of neurology, 60 5
F. Sorge, R. Simone, E. Marano, M. Nolano, G. Orefice, P. Carrieri (1988)Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
Cevoli (1997)Molecular analyis on migraine patients: Exclusion of mutations in CACNA1A4 gene
Ital J Neurol Sci, 4
K. Beauvais, Florence Cavé-Riant, C. Baracé, M. Tardieu, E. Tournier-Lasserve, A. Furby (2004)New CACNA1A Gene Mutation in a Case of Familial Hemiplegic Migraine with Status epilepticus
European Neurology, 52
M. Russell, B. Rasmussen, Kirsten Fenger, J. Olesen (1996)Migraine Without Aura and Migraine with Aura Are Distinct Clinical Entities: A Study of Four Hundred and Eighty-Four Male and Female Migraineurs From the General Population
Michael Russell, Jes Olesen (1996)A nosographic analysis of the migraine aura in a general population.
Brain : a journal of neurology, 119 ( Pt 2)
D. Nyholt, R. Curtain, L. Griffiths (2000)Familial typical migraine: significant linkage and localization of a gene to Xq24–28
Human Genetics, 107
K. Vahedi, C. Denier, A. Ducros, V. Bousson, C. Lévy, H. Chabriat, M. Haguenau, E. Tournier-Lasserve, M. Bousser (2000)CACNA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy
(1988)Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain
(1999)A newmutation in the Chr 19 p calcium channel gene CACL 1 A 4 causing hemiplegic migraine with ataxia
D. Gudbjartsson, K. Jónasson, M. Frigge, A. Kong (2000)Allegro, a new computer program for multipoint linkage analysis
Nature Genetics, 25
A. Ducros, C. Denier, A. Joutel, M. Cécillon, C. Lescoat, K. Vahedi, F. Darcel, E. Vicaut, M. Bousser, E. Tournier-Lasserve (2001)The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel.
The New England journal of medicine, 345 1
S. Battistini, S. Stenirri, M. Piatti, Cecilia Gelfi, P. Righetti, R. Rocchi, F. Giannini, N. Battistini, G. Guazzi, M. Ferrari, P. Carrera (1999)A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia
(2004)A new mutation on the ATP1A2 gene in familial basilar migraine
K. Friend, D. Crimmins, T. Phan, C. Sue, A. Colley, V. Fung, J. Morris, G. Sutherland, R. Richards (1999)Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM
Human Genetics, 105
A. May, Roel Ophoff, G. Terwindt, Christine Urban, Ronald Eijk, J. Haan, H. Diener, Dick Lindhout, R. Frants, L. Sandkuijl, M. Ferrari (1995)Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura
Human Genetics, 96
R. Marconi, M. Fusco, P. Aridon, K. Plewnia, Maja Rossi, S. Carapelli, A. Ballabio, L. Morgante, R. Musolino, A. Epifanio, G. Micieli, G. Michele, G. Casari (2003)Familial hemiplegic migraine type 2 is linked to 0.9Mb region on chromosome 1q23
Annals of Neurology, 53
M. Kaunisto, Hanna Harno, K. Vanmolkot, J. Gargus, G. Sun, E. Hämäläinen, E. Liukkonen, M. Kallela, A. Maagdenberg, R. Frants, M. Färkkilä, A. Palotie, A. Palotie, M. Wessman (2004)A novel missense ATP1A2 mutation in a Finnish family with familial hemiplegic migraine type 2
J. Olesen, P. Goadsby, T. Steiner (2003)The International Classification of Headache Disorders: 2nd edition
The Lancet Neurology, 2
S. Noble-Topham, D. Dyment, M. Cader, R. Ganapathy, J.D. Brown, G. Rice, G. Ebers (2002)Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13
MK Eriksen, L. Thomsen, I. Andersen, F. Nazim, J. Olesen (2004)Clinical Characteristics of 362 Patients with Familial Migraine with Aura
J. Jen, Gilbert Kim, R. Baloh (2004)Clinical spectrum of episodic ataxia type 2
L. McCarthy, D. Hosford, J. Riley, M. Bird, N. White, D. Hewett, S. Peroutka, L. Griffiths, P. Boyd, R. Lea, S. Bhatti, Louise Hosking, C. Hood, Keith Jones, A. Handley, Raj Rallan, K. Lewis, A. Yeo, Pauline Williams, R. Priest, Parveen Khan, C. Donnelly, S. Lumsden, J. O'Sullivan, C. See, D. Smart, S. Shaw-Hawkins, Jaymini Patel, Tony Langrish, W. Feniuk, R. Knowles, M. Thomas, V. Libri, D. Montgomery, P. Manasco, C. Xu, C. Dykes, P. Humphrey, A. Roses, I. Purvis (2001)Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.
Genomics, 78 3
P. Westerhuis1 (2004)The International Classification of Headache Disorders (2nd ed.)
Manuelle Therapie, 8
M. Wessman, M. Kallela, M. Kaunisto, P. Marttila, E. Sobel, J. Hartiala, G. Oswell, S. Leal, J. Papp, E. Hämäläinen, Petra Broas, G. Joslyn, I. Hovatta, T. Hiekkalinna, J. Kaprio, J. Ott, R. Cantor, J. Zwart, M. Ilmavirta, H. Havanka, M. Färkkilä, L. Peltonen, A. Palotie (2002)A susceptibility locus for migraine with aura, on chromosome 4q24.
American journal of human genetics, 70 3
P. Carrera, M. Piatti, S. Stenirri, L. Grimaldi, E. Marchioni, M. Curcio, P. Righetti, M. Ferrari, Cecilia Gelfi (1999)Genetic heterogeneity in Italian families with familial hemiplegic migraine
R. Kendell (1989)Clinical validity
Psychological Medicine, 19
K. Vanmolkot, E. Kors, J. Hottenga, G. Terwindt, J. Haan, W. Hoefnagels, D. Black, L. Sandkuijl, R. Frants, M. Ferrari, A. Maagdenberg (2003)Novel mutations in the Na+, K+‐ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions
Annals of Neurology, 54
J. Jen, Gilbert Kim, Kristen Dudding, R. Baloh (2004)No mutations in CACNA1A and ATP1A2 in probands with common types of migraine.
Archives of neurology, 61 6
M. Lauritzen (2001)Cortical Spreading Depression in Migraine
Epidemiological studies indicate that migraine with typical aura (MA) has a major genetic component but the genes for MA have not been identified. However, the autosomal dominantly inherited familial hemiplegic migraine (FHM) is often caused by mutations in the CACNA1A or ATP1A2 genes. The aim of the study was to investigate if the CACNA1A or ATP1A2 genes are involved in MA with an apparently autosomal dominant mode of inheritance. From a clinic population diagnosed by a trained physician we recruited 34 extended families (comprising 174 MA patients) with an apparently autosomal dominant mode of inheritance of MA. We performed a linkage analysis of 161 of 174 MA patients and 79 unaffected relatives using a framework marker set of 44 markers for chromosome 1 and 22 markers for chromosome 19. Linkage analysis was made with a non‐parametric or autosomal dominant parametric model, either allowing for heterogeneity or not, using an affected only analysis. We identified no linkage to CACNA1A and ATP1A2 loci on chromosome 19 or 1, respectively. Additionally, at least two patients from each family and 92 healthy, unrelated controls were selected for a sequence analysis. We sequenced the 48 exons of CACNA1A and the 23 exons of ATP1A2, including promoter and flanking intron sequences. No polymorphism was identified in the CACNA1A or ATP1A2 genes with a strong correlation to MA. Our study shows that the CACNA1A or ATP1A2 genes are probably not involved in MA. To identify the genes involved in the common forms of migraine, future genetic studies should focus on MA and migraine without aura (MO) and not FHM. © 2006 Wiley‐Liss, Inc.
American Journal of Medical Genetics part B – Wiley
Published: Apr 5, 2006
Keywords: migraine; mutation; linkage; familial hemiplegic migraine
Access the full text.
Sign up today, get DeepDyve free for 14 days.