The therapeutic effects of berberine for gastrointestinal cancers

Amirhossein Davoodvandi; Sahand Sadeghi; Seyed Mohammad Amin Alavi; Seyedeh Shaghayegh Alavi; Ameneh Jafari; Haroon Khan; Michael Aschner; Hamed Mirzaei; Mehran Sharifi; Zatollah Asemi

doi:10.1111/ajco.13941

Epigenetic biomarkers in gastrointestinal cancers: the current state and clinical perspectives

Vedeld, HM; Goel, A; Lind, GE

Surgical treatment of gastric cancer: a 10‐year experience in a high‐volume university hospital

Ramos, MFKP; Pereira, MA; Yagi, OK

Worldwide incidence and mortality of colorectal cancer and human development index (HDI): an ecological study

Goodarzi, E; Beiranvand, R; Naemi, H; Momenabadi, V; Khazaei, Z

Hepatocellular carcinoma in Asia: prevention strategy and planning

Ashtari, S

Epidemiology of esophageal squamous cell carcinoma

Abnet, CC; Arnold, M; Wei, W‐Q

Epidemiology of pancreatic cancer

Ilic, M; Ilic, I

Therapeutic applications of herbal medicines for cancer patients

Yin, S‐Y; Wei, W‐C; Jian, F‐Y; Yang, N‐S

Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation

Wang, L; Li, H; Wang, S

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

Tan, W; Li; Chen, M; Wang, Y

The anti‐cancer mechanisms of berberine: a review

Wang, Y; Liu, Y; Du, X; Ma, H; Yao, J

Berberine attenuates autophagy in adipocytes by targeting BECN1

Deng, Y; Xu, J; Zhang, X

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Imanshahidi, M; Hosseinzadeh, H

Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation

Hu, X; Zhang, Y; Xue, Y; Zhang, Z; Wang, J

Effects of berberine in the gastrointestinal tract—a review of actions and therapeutic implications

Chen, C; Yu, Z; Li, Y; Fichna, J; Storr, M

Berberine derivatives with different pharmacological activities via structural modifications

Xiao, D; Liu, Z; Zhang, S

Study progress of berberine for treating cardiovascular disease

Xia, L‐M; Luo, M‐H

Therapeutic potential and mechanisms of berberine in cardiovascular disease

Zhang, M; Feng, L; Li, J; Chen, L

PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

Long, H‐Z; Cheng, Y; Zhou, Z‐W; Luo, H‐Y; Wen, D‐D; Gao, L‐C

Berberine: a novel therapeutic strategy for cancer

Samadi, P; Sarvarian, P; Gholipour, E

Berberine protects against 6‐OHDA‐induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl‐2 and Nrf2/HO‐1 pathways

Zhang, C; Li, C; Chen, S

Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL

Hsu, W‐H; Hsieh, Y‐S; Kuo, H‐C

Self‐nanoemulsifying system improves oral absorption and enhances anti‐acute myeloid leukemia activity of berberine

Li, J; Yang, L; Shen, R

Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

Chen, W; Miao, Y‐Q; Fan, D‐J

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study

Wang, S; Ren, H; Zhong, H

Expression levels of PTEN, HIF‐1alpha, and VEGF as prognostic factors in ovarian cancer

Shen, W; Li, H‐L; Liu, L; Cheng, J‐X

Pretreatment evaluation of combined HIF‐1α, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer

Sohda, M; Ishikawa, H; Masuda, N

Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF‐1α in vitro and in vivo

Yang, X; Yang, B; Cai, J

LncRNA SNHG16 predicts poor prognosis in ESCC and promotes cell proliferation and invasion by regulating Wnt/beta‐catenin signaling pathway

Han, G; Lu, K‐J; Wang, P; Ye, J; Ye, Y‐Y; Huang, J‐X

Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51

Liu, Q; Jiang, H; Liu, Z

mTOR

Fan, Q‐W; Weiss, WA

Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin‐based chemotherapy

Zhang, H‐Y; Zhang, P‐N; Sun, H

Berberine displays antitumor activity in esophageal cancer cells in vitro

Jiang, S‐X; Qi, B; Yao, W‐J

Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines

Iizuka, N; Miyamoto, K; Okita, K

Involvement of chemokine receptors in breast cancer metastasis

Müller, A; Homey, B; Soto, H

Role of berberine on molecular markers involved in migration of esophageal cancer cells

Mishan, MA; Ahmadiankia, N; Matin, MM

The crosstalk between microRNAs and the Wnt/β‐catenin signaling pathway in cancer

Peng, Y; Zhang, X; Feng, X; Fan, X; Jin, Z

Synergistic anti‐cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells

Ren, K; Zhang, W; Wu, G

Inflammatory regulatory network mediated by the joint action of NF‐kB, STAT3, and AP‐1 factors is involved in many human cancers

Ji, Z; He, L; Regev, A; Struhl, K

Inhibition of activator protein 1 activity by berberine in human hepatoma cells

Fukuda, K; Hibiya, Y; Mutoh, M; Koshiji, M; Akao, S; Fujiwara, H

Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells

Yip, NKY; Ho, WS

Sorafenib in the treatment of advanced hepatocellular carcinoma

Mousa, A

The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects

Tang, W; Chen, Z; Zhang, W

Berberine, a natural plant alkaloid, synergistically sensitizes human liver cancer cells to sorafenib

Huang, Y; Wang, K; Gu, C

TRIM52 plays an oncogenic role in ovarian cancer associated with NF‐kB pathway

Yang, W; Liu, Li; Li, C

Block of NF‐kB signaling accelerates MYC‐driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma

He, J; Gerstenlauer, M; Chan, LK

Induction of apoptosis by berberine in hepatocellular carcinoma HepG2 cells via downregulation of NF‐κB

Li, M; Zhang, M; Zhang, Z‐L

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival

Hassanein, M; Hoeksema, MD; Shiota, M

Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer

Huang, F; Zhao, Y; Zhao, J

A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells

Yoo, HC; Park, SJ; Nam, M

Berberine inhibits growth of liver cancer cells by suppressing glutamine uptake

Zhang, P; Wang, Q; Lin, Z; Yang, P; Dou, K; Zhang, R

HBx‐K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, AP; Tschida, BR; Sham, T‐T

Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway

Tong, W‐G; Ding, X‐Z; Witt, RC; Adrian, TE

Berberine inhibits the apoptosis‐induced metastasis by suppressing the iPLA2/LOX‐5/LTB4 pathway in hepatocellular carcinoma

Zhao, Y; He, K; Zheng, H

FOXOs, cancer and regulation of apoptosis

Fu, Z; Tindall, DJ

A new fork for clinical application: targeting forkhead transcription factors in cancer

Yang, J‐Y; Hung, M‐C

FoxO proteins’ nuclear retention and BH3‐only protein Bim induction evoke mitochondrial dysfunction‐mediated apoptosis in berberine‐treated HepG2 cells

Shukla, S; Rizvi, F; Raisuddin, S; Kakkar, P

Inhibitor of DNA binding proteins: implications in human cancer progression and metastasis

Ke, J; Wu, R; Chen, Y; Abba, ML

Berberine‐induced tumor suppressor p53 up‐regulation gets involved in the regulatory network of MIR‐23a in hepatocellular carcinoma

Wang, N; Zhu, M; Wang, X; Tan, H‐Y; Tsao, S‐W; Feng, Y

Comparative study on the role of berberine and Berberis lycium Royle roots extract against the biochemical markers and cyclin D1 expression in HCC animal model

Mustafa, K; Yu, S; Mohamed, H

Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism

Wang, N; Feng, Y; Zhu, M

Enhancement of apoptosis of human hepatocellular carcinoma SMMC‐7721 cells through synergy of berberine and evodiamine

Wang, X‐N; Han, X; Xu, L‐N

Berberine represses β‐catenin translation involving 4E‐BPs in hepatocellular carcinoma cells

Vishnoi, K; Ke, R; Saini, KS

Berberine regulates the protein expression of multiple tumorigenesis‐related genes in hepatocellular carcinoma cell lines

Chuang, T‐Y; Wu, H‐Li; Min, J; Diamond, M; Azziz, R; Chen, Y‐H

Berberine prevents non‐alcoholic steatohepatitis‐derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice

Luo, Y; Tian, G; Zhuang, Z

Glutamic‐pyruvic transaminase 1 facilitates alternative fuels for hepatocellular carcinoma growth—a small molecule inhibitor, berberine

Guo, W; Tan, H‐Y; Li, S; Wang, N; Feng, Y

9‐O‐benzoyl‐substituted berberine exerts a triglyceride‐lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells

Cao, S; Yu, S; Cheng, L

Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma

Dai, B; Ma, Y; Yang, T

Berberine inhibits human hepatoma cell invasion without cytotoxicity in healthy hepatocytes

Liu, B; Wang, G; Yang, J; Pan, X; Yang, Z; Zang, L

Berberine sensitizes rapamycin‑mediated human hepatoma cell death in vitro

Guo, N; Yan, A; Gao, X

Synthesis and in vitro photocytotoxicity of 9‐/13‐lipophilic substituted berberine derivatives as potential anticancer agents

Lin, H‐J; Ho, J‐H; Tsai, L‐C

Berberine‐induced autophagic cell death by elevating GRP78 levels in cancer cells

La, X; Zhang, L; Li, Z; Yang, P; Wang, Y

Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

Zhang, L; Miao, X‐J; Wang, X

The combination of berberine and irradiation enhances anti‐cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

Hur, J‐M; Hyun, M‐S; Lim, S‐Y; Lee, W‐Y; Kim, D

Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down‐regulation in vitro

Jie, S; Li, H; Tian, Y

Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells

Chi, C‐W; Chang, Y‐F; Chao, T‐W

Berberine upregulates miR‐22‐3p to suppress hepatocellular carcinoma cell proliferation by targeting Sp1

Chen, J; Wu, F‐X; Luo, H‐L

Berberine‐induced apoptotic and autophagic death of HepG2 cells requires AMPK activation

Yu, R; Zhang, Z‐Q; Wang, B; Jiang, H‐X; Cheng, L; Shen, L‐M

Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma

Yang, X; Huang, N

MicroRNA‐21‐3p, a berberine‐induced miRNA, directly down‐regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth

Lo, T‐F; Tsai, W‐C; Chen, S‐T

Regulation of Akt/FoxO3a/Skp2 axis is critically involved in berberine‐induced cell cycle arrest in hepatocellular carcinoma cells

Li, F; Dong, X; Lin, P; Jiang, J

Berberine induced modulation of PHLPP2‐Akt‐MST1 kinase signaling is coupled with mitochondrial impairment and hepatoma cell death

Saxena, S; Shukla, S; Kakkar, P

Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma

Li, J; Li, O; Kan, M

Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147

Hou, Q; Tang, X; Liu, H

Berberine enhances the radiosensitivity of hepatoma cells by Nrf2 pathway

You, X; Cao, X; Lin, Y

Janus nanocarrier‐based co‐delivery of doxorubicin and berberine weakens chemotherapy‐exacerbated hepatocellular carcinoma recurrence

Zhang, F; Jia, Y; Zheng, X

Anti‐hepatocarcinoma effects of berberine nanosuspension against human HepG2 and Huh7 cells as well as H22 tumor bearing mice

Wang, Z‐P; Wu, J‐B; Zhou, Q; Wang, Y‐F; Chen, T

Berberine and S allyl cysteine mediated amelioration of DEN+ CCl4 induced hepatocarcinoma

Sengupta, D; Chowdhury, KD; Sarkar, A; Paul, S; Sadhukhan, GC

Generation of reactive oxygen species by a novel berberine–bile acid analog mediates apoptosis in hepatocarcinoma SMMC‐7721 cells

Li, Q; Zhang, L; Zu, Y; Liu, T; Zhang, B; He, W

In vitro and in vivo antitumor efficacy of berberine‐solid lipid nanoparticles against H22 tumor

Meng, X‐P; Wang, Y‐F; Wang, Z‐P

Citrate synthase expression affects tumor phenotype and drug resistance in human ovarian carcinoma

Chen, L; Liu, T; Zhou, J

Enhanced citrate synthase activity in human pancreatic cancer

Schlichtholz, B; Turyn, J; Goyke, E

Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

Swierczynski, J

Cell‐specific pattern of berberine pleiotropic effects on different human cell lines

Agnarelli, A; Natali, M; Garcia‐Gil, M

Cell metabolomics reveals berberine‐inhibited pancreatic cancer cell viability and metastasis by regulating citrate metabolism

Liu, J; Luo, X; Guo, R; Jing, W; Lu, H

Cancer stem cell: target for anti‐cancer therapy

Tang, C; Ang, BT; Pervaiz, S

Berberine diminishes side population and down‐regulates stem cell‐associated genes in the pancreatic cancer cell lines PANC‐1 and MIA PaCa‐2

Park, SH; Sung, JH; Chung, N

Berberine induces apoptosis via ROS generation in PANC‐1 and MIA‐PaCa2 pancreatic cell lines

Park, SH; Sung, JH; Kim, EJ; Chung, N

Berberine inhibits cell growth and mediates caspase‐independent cell death in human pancreatic cancer cells

Pinto‐Garcia, L; Efferth, T; Torres, A; Hoheisel, J; Youns, M

Dose‐dependent AMPK‐dependent and independent mechanisms of berberine and metformin inhibition of mTORC1, ERK, DNA synthesis and proliferation in pancreatic cancer cells

Ming, M; Sinnett‐Smith, J; Wang, J

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents

Jin, X; Yan, T‐H; Yan, L

Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells

Abrams, SL; Follo, MY; Steelman, LS

Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells

Akula, SM; Candido, S; Libra, M

Matrix metalloproteinase‐9‐1562T allele and its combination with MMP‐2‐735 C allele are risk factors for breast cancer

Rahimi, Z; Yari, K; Rahimi, Z

Effect of melatonin on secreted and induced matrix metalloproteinase‐9 and‐2 activity during prevention of indomethacin‐induced gastric ulcer

Ganguly, K; Maity, P; Reiter, RJ; Swarnakar, S

Green tea polyphenols affect invasiveness of human gastric MKN‐28 cells by inhibition of LPS or TNF‐α induced matrix metalloproteinase‐9/2

Arcone, R; Palma, M; Pagliara, V; Graziani, G; Masullo, M; Nardone, G

Correlations of MMP‐2 and TIMP‐2 gene polymorphisms with the risk and prognosis of gastric cancer

Zhang, D‐Y; Wang, J; Zhang, G‐Qi; Chu, X‐Q; Zhang, J‐L; Zhou, Y

Berberine induced down‐regulation of matrix metalloproteinase‐1,‐2 and‐9 in human gastric cancer cells (SNU‐5) in vitro

Lin, J‐P; Yang, J‐S; Wu, C‐C

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

Mohan, CD; Rangappa, S; Preetham, HD

Role of STAT3 signaling pathway in breast cancer

Ma, J‐H; Qin, L; Li, X

Direct targeting options for STAT3 and STAT5 in cancer

Orlova, A; Wagner, C; De Araujo, ED

Activation of stat3 and stat5 signaling in epithelial ovarian cancer progression: mechanism and therapeutic opportunity

Wu, C‐J; Sundararajan, V; Sheu, B‐C; Huang, RY‐J; Wei, L‐H

Allosteric inhibitors of the STAT3 signaling pathway

Qin, J; Shen, X; Zhang, J; Jia, D

STAT3: versatile functions in non‐small cell lung cancer

Mohrherr, J; Uras, IZ; Moll, HP; Casanova, E

Control of apoptosis and mitotic spindle checkpoint by survivin

Li, F; Ambrosini, G; Chu, EY

New wirings in the survivin networks

Altieri, DC

Survivin is a downstream target and effector of sulindac‐sensitive oncogenic Stat3 signalling in head and neck cancer

Scheper, MA; Nikitakis, NG; Sauk, JJ

Survivin, cancer networks and pathway‐directed drug discovery

Altieri, DC

Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma

Masuda, M; Suzui, M; Yasumatu, R

Berberine and curcumin target survivin and STAT3 in gastric cancer cells and synergize actions of standard chemotherapeutic 5‐fluorouracil

Pandey, A; Vishnoi, K; Mahata, S

A‐FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells

Boiteux, G; Lascombe, I; Roche, E

Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma

Nagao, K; Shinohara, N; Smit, F

Expression of adipocyte/macrophage fatty acid–binding protein in tumor‐associated macrophages promotes breast cancer progression

Hao, J; Yan, F; Zhang, Y

Altered fatty acid‐binding protein 4 (FABP 4) expression and function in human and animal models of hepatocellular carcinoma

Thompson, KJ; Austin, RG; Nazari, SS; Gersin, KS; Iannitti, DA; Mckillop, IH

Berberine suppressed tumor growth through regulating fatty acid metabolism and triggering cell apoptosis via targeting FABPs

Li, L; Peng, Z; Hu, Q

Activation and signaling of the p38 MAP kinase pathway

Zarubin, T; Han, J

Berberine inhibits human gastric cancer cell growth via deactivation of p38/JNK pathway, induction of mitochondrial‐mediated apoptosis, caspase activation and NF‐κB inhibition

Wang, Y; Zhou, M; Shang, D

Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways

Zhang, Q; Wang, X; Cao, S

Akt signaling is associated with the berberine‐induced apoptosis of human gastric cancer cells

Yi, T; Zhuang, L; Song, G; Zhang, B; Li, G; Hu, T

Berberine attenuated proliferation, invasion and migration by targeting the AMPK/HNF4α/WNT5A pathway in gastric carcinoma

Hu, Q; Li, L; Zou, X; Xu, L; Yi, P

Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU‐5 cell line

Lin, J‐P; Yang, J‐S; Lee, J‐H; Hsieh, W‐T; Chung, J‐G

Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Wang, J; Yang, S; Cai, X

Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR‐203

You, H‐Y; Xie, X‐M; Zhang, W‐J; Zhu, H‐L; Jiang, F‐Z

Integration of microRNA‐mRNA profiles and pathway analysis of plant isoquinoline alkaloid berberine in sgc‐7901 gastric cancers cells

Yang, Y; Zhang, N; Li, K; Chen, J; Qiu, L; Zhang, J

MAPK pathways are involved in the inhibitory effect of berberine hydrochloride on gastric cancer MGC 803 cell proliferation and IL‐8 secretion in vitro and in vivo

Li, H‐L; Wu, H; Zhang, B‐B; Shi, H‐L; Wu, X‐J

Synergistic inhibitory effect of berberine and d‐limonene on human gastric carcinoma cell line MGC803

Zhang, X‐Z; Wang, L; Liu, D‐W; Tang, G‐Y; Zhang, H‐Y

Berberine counteracts enhanced IL‐8 expression of AGS cells induced by evodiamine

Shi, H‐L; Wu, X‐J; Liu, Y; Xie, J‐Q

Insulin‐like growth factor 2 mRNA‐binding protein 3 influences sensitivity to anti‐IGF system agents through the translational regulation of IGF1R

Mancarella, C; Pasello, M; Manara, MC

Insulin growth factor‐2 binding protein 3 (IGF2BP3) is a glioblastoma‐specific marker that activates phosphatidylinositol 3‐kinase/mitogen‐activated protein kinase (PI3K/MAPK) pathways by modulating IGF‐2

Suvasini, R; Shruti, B; Thota, B

The role of the oncofetal IGF2 mRNA‐binding protein 3 (IGF2BP3) in cancer

Lederer, M; Bley, N; Schleifer, C; Hüttelmaier, S

IMP3 expression in biopsy specimens of colorectal cancer predicts lymph node metastasis and TNM stage

Wei, Q; Huang, X; Fu, B

Circulating and tissue IMP3 levels are correlated with poor survival in renal cell carcinoma

Tschirdewahn, S; Panic, A; Püllen, L

IMP3 expression in biopsy specimens as a diagnostic biomarker for colorectal cancer

Wei, Q; Zhou, H; Zhong, L

Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo

Xu, W; Sheng, Y; Guo, Y

Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3

Zhang, Y; Liu, X; Yu, M

SREBP‐1, a basic‐helix‐loop‐helix‐leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

Yokoyama, C; Wang, X; Briggs, MR

Structure of the human gene encoding sterol regulatory element binding protein‐1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11. 2 and 22q13

Hua, X; Wu, J; Goldstein, JL; Brown, MS; Hobbs, HH

SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF‐κB pathway activation

Gao, Y; Nan, X; Shi, X

Berberine suppresses colon cancer cell proliferation by inhibiting the scap/srebp‐1 signaling pathway‐mediated lipogenesis

Liu, Y; Hua, W; Li, Y

Berberine inhibits proliferation and down‐regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells

Wang, L; Cao, H; Lu, N

Berberine and Tinospora cordifolia exert a potential anticancer effect on colon cancer cells by acting on specific pathways

Palmieri, A; Scapoli, L; Iapichino, A

Berberine inhibits invasion and metastasis of colorectal cancer cells via COX‐2/PGE2 mediated JAK2/STAT3 signaling pathway

Liu, X; Ji, Q; Ye, N

Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78

Gong, C; Hu, X; Xu, Y

Berberine promotes apoptosis of colorectal cancer via regulation of the long non‐coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2)/AU‐binding factor 1 (AUF1)/B‐Cell CLL/lymphoma 2 (Bcl‐2) axis

Dai, W; Mu, L; Cui, Y

Berberine regulates AMP‐activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice

Li, W; Hua, B; Saud, SM

Berberine, a natural isoquinoline alkaloid, induces NAG‐1 and ATF3 expression in human colorectal cancer cells

Piyanuch, R; Sukhthankar, M; Wandee, G; Baek, SJ

Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor‐bearing mice using polyamines as targets

Wu, Y‐Y; Li, T‐M; Zang, L‐Q; Liu, B; Wang, G‐X

Effect of evodiamine and berberine on miR‐429 as an oncogene in human colorectal cancer

Liu, H; Huang, C; Wu, L; Wen, B

Inhibition by berberine of cyclooxygenase‐2 transcriptional activity in human colon cancer cells

Fukuda, K; Hibiya, Y; Mutoh, M; Koshiji, M; Akao, S; Fujiwara, H

Long non‑coding RNA CASC2 enhances berberine‑induced cytotoxicity in colorectal cancer cells by silencing BCL2

Dai, W; Mu, L; Cui, Y

Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo

Cai, Y; Xia, Q; Luo, R

Berberine inhibits human colon cancer cell migration via AMP‐activated protein kinase‐mediated downregulation of integrin β1 signaling

Park, J‐J; Seo, S‐M; Kim, EJ

Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB

Yu, M; Tong, X; Qi, B

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

Zhang, J; Cao, H; Zhang, B

Berberine induces caspase‐independent cell death in colon tumor cells through activation of apoptosis‐inducing factor

Wang, L; Liu, L; Shi, Y

Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

Su, Y‐H; Tang, W‐C; Cheng, Y‐W

Effects of berberine on arylamine N‐acetyltransferase activity in human colon tumor cells

Lin, JG; Chung, JG; Wu, LT; Chen, GW; Chang, HL; Wang, TF

Effect of new berberine derivatives on colon cancer cells

Guamán Ortiz, LM; Croce, AL; Aredia, F

The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells

Chidambara Murthy, KN; Jayaprakasha, GK; Patil, BS

Multiple effects of berberine derivatives on colon cancer cells

Guamán Ortiz, LM; Tillhon, M; Parks, M

Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT‐8 cells

Xu, L‐N; Lu, B‐N; Hu, M‐M

Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β‐catenin signaling

Wu, K; Yang, Q; Mu, Y

Berberine inhibits colitis‐associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling‐involved tumor cell growth

Li, D; Zhang, Y; Liu, K

Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells

Mao, L; Chen, Q; Gong, K

Potential prophylactic effect of berberine against rat colon carcinoma induce by 1, 2‐dimethyl hydrazine

Ghareeb, AE; Moawed, FSM; Ghareeb, DA; Kandil, EI

Biological activity of berberine—a summary update

Och, A; Podgórski, R; Nowak, R

Regulation of cell signaling pathways by berberine in different cancers: searching for missing pieces of an incomplete jig‐saw puzzle for an effective cancer therapy

Farooqi, AA; Qureshi, MZ; Khalid, S

Protective effects of berberine on radiation‐induced lung injury via intercellular adhesion molecular‐1 and transforming growth factor‐beta‐1 in patients with lung cancer

Liu, Y; Yu, H; Zhang, C

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double‐blinded, randomised controlled study

Chen, Y‐X; Gao, Q‐Y; Zou, T‐H

Development and evaluation of vitamin E D‐α‐tocopheryl polyethylene glycol 1000 succinate‐mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical

Shen, R; Kim, JJ; Yao, M; Elbayoumi, TA

Anticancer effects and mechanisms of berberine from medicinal herbs: an update review

Xiong, R‐G; Huang, S‐Y; Wu, S‐X

Bioformulation of silver nanoparticles as berberine carrier cum anticancer agent against breast cancer

Bhanumathi, R; Vimala, K; Shanthi, K; Thangaraj, R; Kannan, S

GADD153 mediates berberine‐induced apoptosis in human cervical cancer Ca ski cells

Lin, J‐P; Yang, J‐S; Chang, N‐W

Berberine‐loaded liquid crystalline nanoparticles inhibit non‐small cell lung cancer proliferation and migration in vitro

Paudel, KR; Mehta, M; Yin, GHS

Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL/6 mice

Wang, Z; Wu, J; Zhou, Q; Wang, Y; Chen, T

Efficacy and safety of Berberine alone for several metabolic disorders: a systematic review and meta‐analysis of randomized clinical trials

Ye, Y; Liu, X; Wu, N

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: a systematic review and meta‐analysis

Fang, S; Guo, S; Du, S

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The therapeutic effects of berberine for gastrointestinal cancers

The therapeutic effects of berberine for gastrointestinal cancers

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The therapeutic effects of berberine for gastrointestinal cancers

The therapeutic effects of berberine for gastrointestinal cancers

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