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Thymocyte circular DNA excised from T cell receptor alpha‐delta gene complex.

Thymocyte circular DNA excised from T cell receptor alpha‐delta gene complex. We have characterized thymocyte circular DNA excised from the T cell receptor alpha‐delta gene complex. Some delta gene clones contained unusual recombinant structures derived from V‐(D)‐J joining: (i) a reciprocal joint of direct V to J delta joining, skipping the D delta segment; (ii) a V‐D delta coding joint lacking an adjacent D delta‐J delta coding joint; (iii) a V‐ D structure containing two D delta segments. Many of the alpha gen clones contained both coding and reciprocal joints of V alpha‐to‐J alpha joining on the same structure. Most of these coding joints were out of phase; however, in one clone there was an in‐phase V‐J alpha structure. Interestingly, some alpha gene clones contained the same V gene sequence as rearranged in the delta gene clone, indicating that the same V gene family, at least in part, could be utilized for both the alpha and delta gene systems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

Thymocyte circular DNA excised from T cell receptor alpha‐delta gene complex.

The EMBO Journal , Volume 7 (6) – Jun 1, 1988

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Publisher
Wiley
Copyright
© EMBO
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1002/j.1460-2075.1988.tb02994.x
Publisher site
See Article on Publisher Site

Abstract

We have characterized thymocyte circular DNA excised from the T cell receptor alpha‐delta gene complex. Some delta gene clones contained unusual recombinant structures derived from V‐(D)‐J joining: (i) a reciprocal joint of direct V to J delta joining, skipping the D delta segment; (ii) a V‐D delta coding joint lacking an adjacent D delta‐J delta coding joint; (iii) a V‐ D structure containing two D delta segments. Many of the alpha gen clones contained both coding and reciprocal joints of V alpha‐to‐J alpha joining on the same structure. Most of these coding joints were out of phase; however, in one clone there was an in‐phase V‐J alpha structure. Interestingly, some alpha gene clones contained the same V gene sequence as rearranged in the delta gene clone, indicating that the same V gene family, at least in part, could be utilized for both the alpha and delta gene systems.

Journal

The EMBO JournalWiley

Published: Jun 1, 1988

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