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Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia

Towards an understanding of the biology and targeted treatment of paediatric relapsed acute... Acute lymphoblastic leukaemia is the most common childhood cancer and for those children who relapse, prognosis is poor and new therapeutic strategies are needed. Recurrent pathways implicated in relapse include RAS, JAK STAT, cell cycle, epigenetic regulation, B cell development, glucocorticoid response, nucleotide metabolism and DNA repair. Targeting these pathways is a rational therapeutic strategy and may deliver novel, targeted therapies into the clinic. Relapse often stems from a minor clone present at diagnosis and thus analysis of persisting leukaemia during upfront therapy may allow targeted drug intervention to prevent relapse. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Haematology Wiley

Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia

British Journal of Haematology , Volume 172 (5) – Mar 1, 2016

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References (104)

Publisher
Wiley
Copyright
"Copyright © 2016 John Wiley & Sons Ltd"
ISSN
0007-1048
eISSN
1365-2141
DOI
10.1111/bjh.13852
pmid
26568036
Publisher site
See Article on Publisher Site

Abstract

Acute lymphoblastic leukaemia is the most common childhood cancer and for those children who relapse, prognosis is poor and new therapeutic strategies are needed. Recurrent pathways implicated in relapse include RAS, JAK STAT, cell cycle, epigenetic regulation, B cell development, glucocorticoid response, nucleotide metabolism and DNA repair. Targeting these pathways is a rational therapeutic strategy and may deliver novel, targeted therapies into the clinic. Relapse often stems from a minor clone present at diagnosis and thus analysis of persisting leukaemia during upfront therapy may allow targeted drug intervention to prevent relapse.

Journal

British Journal of HaematologyWiley

Published: Mar 1, 2016

Keywords: ; ;

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