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Variants of the serotonin transporter gene and NEO‐PI‐R Neuroticism: No association in the BLSA and SardiNIA samples

Variants of the serotonin transporter gene and NEO‐PI‐R Neuroticism: No association in the BLSA... The polymorphism in the serotonin transporter gene promoter region (5‐HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism‐related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5‐HTTLPR. However, studies that used the NEO‐PI‐R or related instruments (NEO‐PI, NEO‐FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO‐PI‐R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO‐PI‐R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5‐HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry‐Hostility, Depression, Self‐Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5‐HTT variants and Neuroticism‐related traits. © 2009 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics part B Wiley

Variants of the serotonin transporter gene and NEO‐PI‐R Neuroticism: No association in the BLSA and SardiNIA samples

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References (53)

Publisher
Wiley
Copyright
Copyright © 2009 Wiley‐Liss, Inc., A Wiley Company
ISSN
1552-4841
eISSN
1552-485X
DOI
10.1002/ajmg.b.30932
pmid
19199283
Publisher site
See Article on Publisher Site

Abstract

The polymorphism in the serotonin transporter gene promoter region (5‐HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism‐related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5‐HTTLPR. However, studies that used the NEO‐PI‐R or related instruments (NEO‐PI, NEO‐FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO‐PI‐R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO‐PI‐R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5‐HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry‐Hostility, Depression, Self‐Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5‐HTT variants and Neuroticism‐related traits. © 2009 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics part B – Wiley

Published: Dec 5, 2009

Keywords: personality; depression; anxiety; 5‐HTT; GWA

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