Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

WHO 2016 Classification of gliomas

WHO 2016 Classification of gliomas Gliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern (‘nondiffuse gliomas’). In the revised fourth edition of the WHO Classification of CNS tumours published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time, a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion. Following this approach, the diagnosis of (anaplastic) oligoastrocytoma can be expected to largely disappear. Furthermore, in the WHO 2016 Classification gliomatosis cerebri is not an entity anymore but is now considered as a growth pattern. The most important changes in the very diverse group of ‘nondiffuse’ gliomas and neuronal‐glial tumours are the introduction of anaplastic pleomorphic xanthoastrocytoma, of diffuse leptomeningeal glioneuronal tumour and of RELA fusion‐positive ependymoma as entities. In the last part of this review, after very briefly touching upon classification of neuronal, choroid plexus and pineal region tumours, some practical implications and challenges associated with the WHO 2016 Classification of gliomas are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropathology & Applied Neurobiology Wiley

WHO 2016 Classification of gliomas

Loading next page...
 
/lp/wiley/who-2016-classification-of-gliomas-mBHVW9ET0c

References (53)

  • D. Brat, R. Verhaak, K. Aldape, W. Yung, S. Salama, L. Cooper, Esther Rheinbay, C. Miller, M. Vitucci, O. Morozova, A. Robertson, H. Noushmehr, P. Laird, A. Cherniack, R. Akbani, J. Huse, G. Ciriello, L. Poisson, J. Barnholtz-Sloan, M. Berger, C. Brennan, R. Colen, H. Colman, A. Flanders, C. Giannini, Mia Grifford, A. Iavarone, R. Jain, I. Joseph, Jaegil Kim, K. Kasaian, T. Mikkelsen, Bradley Murray, B. O'neill, L. Pachter, D. Parsons, C. Sougnez, E. Sulman, S. Vandenberg, Erwin Meir, A. Deimling, Hailei Zhang, D. Crain, Kevin Lau, D. Mallery, S. Morris, J. Paulauskis, R. Penny, T. Shelton, M. Sherman, P. Yena, Aaron Black, Jay Bowen, Katie Dicostanzo, J. Gastier-Foster, K. Leraas, T. Lichtenberg, C. Pierson, N. Ramirez, Cynthia Taylor, Stephanie Weaver, L. Wise, E. Zmuda, Tanja Davidsen, John Demchok, G. Eley, M. Ferguson, C. Hutter, Kenna Shaw, B. Ozenberger, Margi Sheth, H. Sofia, R. Tarnuzzer, Zhining Wang, Liming Yang, J. Zenklusen, Brenda Ayala, J. Baboud, Sudha Chudamani, M. Jensen, Jia Liu, T. Pihl, R. Raman, Yunhu Wan, Ye Wu, Adrian Ally, J. Auman, M. Balasundaram, S. Balu, S. Baylin, R. Beroukhim, M. Bootwalla, R. Bowlby, C. Bristow, Denise Brooks, Y. Butterfield, R. Carlsen, S. Carter, L. Chin, Andy Chu, E. Chuah, K. Cibulskis, A. Clarke, Simon Coetzee, Noreen Dhalla, T. Fennell, Sheila Fisher, S. Gabriel, G. Getz, R. Gibbs, R. Guin, Angela Hadjipanayis, D. Hayes, T. Hinoue, K. Hoadley, R. Holt, A. Hoyle, S. Jefferys, Steven Jones, Corbin Jones, R. Kucherlapati, Phillip Lai, E. Lander, Semin Lee, Lee Lichtenstein, Yussanne Ma, D. Maglinte, Harshad Mahadeshwar, M. Marra, Michael Mayo, S. Meng, M. Meyerson, P. Mieczkowski, Richard Moore, Lisle Mose, A. Mungall, A. Pantazi, Michael Parfenov, P. Park, J. Parker, C. Perou, A. Protopopov, X. Ren, J. Roach, Thaís Sabedot, J. Schein, S. Schumacher, J. Seidman, S. Seth, Hui Shen, J. Simons, Payal Sipahimalani, Matthew Soloway, Xingzhi Song, Huandong Sun, B. Tabak, Angela Tam, Donghui Tan, Jiabin Tang, N. Thiessen, T. Triche, D. Berg, Umadevi Veluvolu, S. Waring, D. Weisenberger, M. Wilkerson, Tina Wong, Junyuan Wu, Liu Xi, A. Xu, Lixing Yang, Travis Zack, Jianhua Zhang, B. Aksoy, H. Arachchi, C. Benz, Brady Bernard, Daniel Carlin, Juok Cho, D. Dicara, S. Frazer, G. Fuller, Jianjiong Gao, N. Gehlenborg, D. Haussler, David Heiman, L. Iype, A. Jacobsen, Z. Ju, Sol Katzman, Hoon Kim, T. Knijnenburg, R. Kreisberg, M. Lawrence, William Lee, Kalle Leinonen, Pei Lin, Shiyun Ling, Wenbin Liu, Yingchun Liu, Yuexin Liu, Yiling Lu, G. Mills, S. Ng, M. Noble, Evan Paull, A. Rao, Sheila Reynolds, G. Saksena, Zachary Sanborn, C. Sander, N. Schultz, Y. Şenbabaoğlu, R. Shen, I. Shmulevich, Rileen Sinha, Josh Stuart, S. Sumer, Yichao Sun, Natalie Tasman, B. Taylor, Douglas Voet, Nils Weinhold, J. Weinstein, Da Yang, K. Yoshihara, Siyuan Zheng, Wei Zhang, L. Zou, T. Abel, S. Sadeghi, M. Cohen, J. Eschbacher, E. Hattab, A. Raghunathan, M. Schniederjan, Dina Aziz, G. Barnett, Wendi Barrett, D. Bigner, L. Boice, C. Brewer, C. Calatozzolo, B. Campos, C. Carlotti, T. Chan, L. Cuppini, Erin Curley, S. Cuzzubbo, K. Devine, F. DiMeco, R. Duell, J. Elder, Ashley Fehrenbach, G. Finocchiaro, W. Friedman, J. Fulop, J. Gardner, Beth Hermes, C. Herold‐Mende, C. Jungk, A. Kendler, N. Lehman, E. Lipp, Ouida Liu, Randy Mandt, Mary McGraw, R. McLendon, C. McPherson, L. Neder, P. Nguyen, Ardene Noss, R. Nunziata, Q. Ostrom, C. Palmer, A. Perin, B. Pollo, A. Potapov, O. Potapova, W. Rathmell, D. Rotin, L. Scarpace, C. Schilero, Kelly Senecal, K. Shimmel, V. Shurkhay, Suzanne Sifri, Rosy Singh, A. Sloan, Kathy Smolenski, S. Staugaitis, Ruth Steele, L. Thorne, D. Tirapelli, A. Unterberg, Mahitha Vallurupalli, Yun Wang, R. Warnick, Felicia Williams, Yingli Wolinsky, Sue Bell, Mara Rosenberg, C. Stewart, F. Huang, J. Grimsby, Amie Radenbaugh, Jianan Zhang (2015)

    Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

    The New England journal of medicine, 372 26

  • J. Huse, M. Edgar, John Halliday, I. Mikolaenko, E. Lavi, M. Rosenblum (2013)

    Multinodular and Vacuolating Neuronal Tumors of the Cerebrum: 10 Cases of a Distinctive Seizure‐Associated Lesion

    Brain Pathology, 23

  • D. Ellison, M. Koçak, D. Figarella-Branger, G. Felice, G. Catherine, T. Pietsch, D. Frappaz, M. Massimino, J. Grill, J. Boyett, R. Grundy (2011)

    Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts

    Journal of Negative Results in Biomedicine, 10

  • D. Sturm, D. Sturm, B. Orr, U. Toprak, V. Hovestadt, David Jones, D. Capper, D. Capper, M. Sill, I. Buchhalter, P. Northcott, Irina Leis, M. Ryzhova, C. Koelsche, C. Koelsche, E. Pfaff, E. Pfaff, Sariah Allen, G. Balasubramanian, B. Worst, B. Worst, K. Pajtler, S. Brabetz, Pascal Johann, Pascal Johann, F. Sahm, F. Sahm, J. Reimand, J. Reimand, A. Mackay, Diana Carvalho, M. Remke, J. Phillips, A. Perry, Cynthia Cowdrey, R. Drissi, M. Fouladi, F. Giangaspero, M. Łastowska, W. Grajkowska, W. Scheurlen, T. Pietsch, C. Hagel, J. Gojo, D. Lötsch, W. Berger, I. Slavc, C. Haberler, A. Jouvet, S. Holm, S. Hofer, M. Prinz, C. Keohane, I. Fried, C. Mawrin, D. Scheie, B. Mobley, M. Schniederjan, M. Santi, A. Buccoliero, S. Dahiya, C. Kramm, A. Bueren, K. Hoff, S. Rutkowski, C. Herold‐Mende, M. Frühwald, T. Milde, T. Milde, M. Hasselblatt, Pieter Wesseling, Pieter Wesseling, J. Rössler, U. Schüller, M. Ebinger, J. Schittenhelm, S. Frank, R. Grobholz, I. Vajtai, V. Hans, R. Schneppenheim, K. Zitterbart, V. Collins, E. Aronica, P. Varlet, S. Puget, C. Dufour, J. Grill, D. Figarella-Branger, M. Wolter, M. Schuhmann, T. Shalaby, M. Grotzer, T. Meter, C. Monoranu, J. Felsberg, G. Reifenberger, M. Snuderl, Lynn Forrester, J. Koster, R. Versteeg, R. Volckmann, P. Sluis, S. Wolf, T. Mikkelsen, A. Gajjar, K. Aldape, A. Moore, Michael Taylor, Chris Jones, N. Jabado, M. Karajannis, R. Eils, M. Schlesner, P. Lichter, A. Deimling, A. Deimling, Stefan Pfister, Stefan Pfister, D. Ellison, A. Korshunov, A. Korshunov, M. Kool (2016)

    New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Cell, 164

  • D. Castel, C. Philippe, R. Calmon, L. Dret, Nathalène Truffaux, N. Boddaert, M. Pages, Kathryn Taylor, P. Saulnier, L. Lacroix, A. Mackay, Chris Jones, C. Sainte‐Rose, T. Blauwblomme, F. Andreiuolo, S. Puget, J. Grill, P. Varlet, M. Debily (2015)

    Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

    Acta Neuropathologica, 130

  • A. Perry, P. Wesseling (2016)

    Histologic classification of gliomas.

    Handbook of clinical neurology, 134

  • Gang Easto, Gang Wu, Alexander Diaz, Barbara Paugh, Sherri Rankin, B. Ju, Yongjin Li, Xiaoyan Zhu, Chunxu Qu, Xiang Chen, Junyuan Zhang, J. Easton, M. Edmonson, Xiaotu Ma, Charles Lu, Panduka Nagahawatte, Erin Hedlund, Michael Rusch, S. Pounds, T. Lin, A. Onar-Thomas, R. Huether, R. Kriwacki, Matthew Parker, P. Gupta, J. Becksfort, Lei Wei, H. Mulder, Kristy Boggs, Bhavin Vadodaria, D. Yergeau, Jake Russell, Kerri Ochoa, R. Fulton, L. Fulton, Chris Jones, F. Boop, A. Broniscer, C. Wetmore, A. Gajjar, L. Ding, E. Mardis, R. Wilson, Michael Taylor, J. Downing, D. Ellison, Jinghui Zhang, S. Baker (2014)

    The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Nature genetics, 46

  • F. Vettermann, J. Neumann, B. Suchorska, Peter Bartenstein, Armin Giese, M. Dorostkar, Nathalie Albert, Ulrich Schüller (2017)

    K27M midline gliomas display malignant progression by imaging and histology

    Neuropathology and Applied Neurobiology, 43

  • D. Louis, A. Perry, P. Burger, D. Ellison, G. Reifenberger, A. Deimling, K. Aldape, D. Brat, V. Collins, C. Eberhart, D. Figarella-Branger, G. Fuller, F. Giangaspero, C. Giannini, C. Hawkins, P. Kleihues, A. Korshunov, J. Kros, M. Lopes, H. Ng, H. Ohgaki, W. Paulus, T. Pietsch, M. Rosenblum, E. Rushing, F. Soylemezoğlu, O. Wiestler, P. Wesseling (2014)

    International Society of Neuropathology‐Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading

    Brain Pathology, 24

  • D. Reuss, A. Kratz, F. Sahm, D. Capper, D. Schrimpf, C. Koelsche, V. Hovestadt, M. Bewerunge-Hudler, David Jones, J. Schittenhelm, M. Mittelbronn, E. Rushing, M. Simon, M. Westphal, A. Unterberg, M. Platten, W. Paulus, G. Reifenberger, J. Tonn, K. Aldape, S. Pfister, A. Korshunov, M. Weller, C. Herold‐Mende, W. Wick, S. Brandner, A. Deimling (2015)

    Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

    Acta Neuropathologica, 130

  • N. Joyon, A. Tauziède-Espariat, A. Alentorn, M. Giry, D. Castel, Laurent Capelle, Marc Zanello, Pascale Varlet, Franck Bielle (2017)

    K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant transformation extends the histopathological spectrum of the histone H3 oncogenic pathway

    Neuropathology and Applied Neurobiology, 43

  • Hiromichi Suzuki, Kosuke Aoki, K. Chiba, Yusuke Sato, Y. Shiozawa, Y. Shiraishi, Teppei Shimamura, A. Niida, K. Motomura, F. Ohka, Takashi Yamamoto, K. Tanahashi, Melissa Ranjit, T. Wakabayashi, T. Yoshizato, K. Kataoka, Kenichi Yoshida, Y. Nagata, A. Sato-Otsubo, Hiroko Tanaka, M. Sanada, Y. Kondo, Hideo Nakamura, M. Mizoguchi, T. Abe, Y. Muragaki, R. Watanabe, I. Ito, S. Miyano, A. Natsume, S. Ogawa (2015)

    Mutational landscape and clonal architecture in grade II and III gliomas

    Nature Genetics, 47

  • Matthew Parker, K. Mohankumar, C. Punchihewa, R. Weinlich, J. Dalton, Yongjin Li, Ryan Lee, R. Tatevossian, T. Phoenix, R. Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, K. Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatte, Erin Hedlund, D. Finkelstein, Gang Wu, S. Shurtleff, J. Easton, Kristy Boggs, D. Yergeau, Bhavin Vadodaria, H. Mulder, Jared Becksford, P. Gupta, R. Huether, Jing Ma, G. Song, A. Gajjar, T. Merchant, F. Boop, Amy Smith, L. Ding, Charles Lu, Kerri Ochoa, David Zhao, R. Fulton, L. Fulton, E. Mardis, R. Wilson, J. Downing, D. Green, Jinghui Zhang, D. Ellison, R. Gilbertson (2014)

    C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma

    Nature, 506

  • C. Hartmann, B. Hentschel, M. Tatagiba, J. Schramm, O. Schnell, C. Seidel, R. Stein, G. Reifenberger, T. Pietsch, A. Deimling, M. Loeffler, M. Weller (2011)

    Molecular Markers in Low-Grade Gliomas: Predictive or Prognostic?

    Clinical Cancer Research, 17

  • J. Schwartzentruber, A. Korshunov, Xiao-yang Liu, David Jones, E. Pfaff, K. Jacob, D. Sturm, A. Fontebasso, Dong Quang, M. Tönjes, V. Hovestadt, S. Albrecht, M. Kool, A. Nantel, Carolin Konermann, A. Lindroth, N. Jäger, T. Rausch, M. Ryzhova, J. Korbel, T. Hielscher, P. Hauser, M. Garami, Á. Klekner, L. Bognár, M. Ebinger, M. Schuhmann, W. Scheurlen, A. Pekrun, M. Frühwald, W. Roggendorf, C. Kramm, M. Dürken, J. Atkinson, P. Lepage, A. Montpetit, M. Zakrzewska, K. Zakrzewski, P. Liberski, Zhifeng Dong, P. Siegel, A. Kulozik, M. Zapatka, A. Guha, D. Malkin, J. Felsberg, G. Reifenberger, A. Deimling, K. Ichimura, V. Collins, H. Witt, H. Witt, T. Milde, T. Milde, O. Witt, Cindy Zhang, P. Castelo-Branco, P. Lichter, D. Faury, U. Tabori, C. Plass, J. Majewski, S. Pfister, S. Pfister, N. Jabado (2012)

    Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Nature, 482

  • A. Korshunov, M. Ryzhova, V. Hovestadt, S. Bender, D. Sturm, D. Capper, Jochen Meyer, D. Schrimpf, M. Kool, P. Northcott, O. Zheludkova, T. Milde, O. Witt, A. Kulozik, G. Reifenberger, N. Jabado, A. Perry, P. Lichter, A. Deimling, S. Pfister, David Jones (2015)

    Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

    Acta Neuropathologica, 129

  • D. Louis, A. Perry, G. Reifenberger, A. Deimling, D. Figarella-Branger, W. Cavenee, H. Ohgaki, O. Wiestler, P. Kleihues, D. Ellison (2016)

    The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

    Acta Neuropathologica, 131

  • J. Tanboon, E. Williams, D. Louis (2016)

    The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas

    Journal of Neuropathology & Experimental Neurology, 75

  • Louis N, Ohgaki H, Cavenee K (1982)

    The classification of tumours of the central nervous system.

    Neuropathology and applied neurobiology, 8 1

  • G. López, N. Bush, M. Berger, A. Perry, D. Solomon (2017)

    Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma

    Acta Neuropathologica Communications, 5

  • Commentary on “ Histone H 3 F 3 A and HIST 1 H 3 B K 27 M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

  • H. Ohgaki, P. Kleihues (2012)

    The Definition of Primary and Secondary Glioblastoma

    Clinical Cancer Research, 19

  • D. Parsons, Siân Jones, Xiaosong Zhang, Jimmy Lin, R. Leary, P. Angenendt, P. Mankoo, H. Carter, I. Siu, G. Gallia, A. Olivi, R. McLendon, B. Rasheed, S. Keir, T. Nikolskaya, Y. Nikolsky, D. Busam, H. Tekleab, L. Diaz, James Hartigan, Douglas Smith, R. Strausberg, S. Marie, S. Shinjo, Hai Yan, G. Riggins, D. Bigner, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. Velculescu, K. Kinzler (2008)

    An Integrated Genomic Analysis of Human Glioblastoma Multiforme

    Science, 321

  • M. Gessi, D. Capper, F. Sahm, Kristin Huang, A. Deimling, S. Tippelt, G. Fleischhack, Daniel Scherbaum, J. Alfer, B. Juhnke, K. Hoff, S. Rutkowski, M. Warmuth-Metz, L. Chavez, S. Pfister, T. Pietsch, David Jones, D. Sturm (2016)

    Evidence of H3 K27M mutations in posterior fossa ependymomas

    Acta Neuropathologica, 132

  • P. Bandopadhayay, P. Bandopadhayay, L. Ramkissoon, P. Jain, G. Bergthold, G. Bergthold, J. Wala, J. Wala, Rhamy Zeid, S. Schumacher, S. Schumacher, Laura Urbanski, Ryan O’Rourke, Ryan O’Rourke, W. Gibson, W. Gibson, K. Pelton, S. Ramkissoon, Harry Han, Yuankun Zhu, N. Choudhari, Amanda Silva, Amanda Silva, Katie Boucher, Rosemary Henn, Y. Kang, David Knoff, B. Paolella, B. Paolella, A. Gladden-Young, P. Varlet, M. Pages, Peleg Horowitz, Alexander Federation, H. Malkin, A. Tracy, Sara Seepo, M. Ducar, P. Hummelen, M. Santi, A. Buccoliero, M. Scagnet, D. Bowers, C. Giannini, S. Puget, C. Hawkins, U. Tabori, Á. Klekner, L. Bognár, P. Burger, C. Eberhart, F. Rodriguez, D. Hill, S. Mueller, D. Haas-Kogan, D. Haas-Kogan, J. Phillips, S. Santagata, C. Stiles, J. Bradner, J. Bradner, N. Jabado, A. Goren, J. Grill, A. Ligon, L. Goumnerova, A. Waanders, P. Storm, M. Kieran, K. Ligon, K. Ligon, R. Beroukhim, R. Beroukhim, A. Resnick (2016)

    MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism

    Nature genetics, 48

  • DN Louis, A Perry, P Burger, DW Ellison, G Reifenberger, A Deimling, K Aldape, D Brat, VP Collins, C Eberhart, D Figarella‐Branger, GN Fuller, F Giangaspero, C Giannini, C Hawkins, P Kleihues, A Korshunov, JM Kros, M Beatriz Lopes, HK Ng, H Ohgaki, W Paulus, T Pietsch, M Rosenblum, E Rushing, F Soylemezoglu, O Wiestler, P Wesseling (2014)

    International Society Of Neuropathology‐Haarlem. International Society Of Neuropathology‐Haarlem consensus guidelines for nervous system tumor classification and grading

    , 24

  • G Wu, AK Diaz, BS Paugh, SL Rankin, B Ju, Y Li, X Zhu, C Qu, X Chen, J Zhang, J Easton, M Edmonson, X Ma, C Lu, P Nagahawatte, E Hedlund, M Rusch, S Pounds, T Lin, A Onar‐Thomas, R Huether, R Kriwacki, M Parker, P Gupta, J Becksfort, L Wei, HL Mulder, K Boggs, B Vadodaria, D Yergeau, JC Russell, K Ochoa, RS Fulton, LL Fulton, C Jones, FA Boop, A Broniscer, C Wetmore, A Gajjar, L Ding, ER Mardis, RK Wilson, MR Taylor, JR Downing, DW Ellison, J Zhang, SJ Baker (2014)

    St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non‐brainstem high‐grade glioma

    , 46

  • P. Wesseling, M. Bent, A. Perry (2015)

    Oligodendroglioma: pathology, molecular mechanisms and markers

    Acta Neuropathologica, 129

  • K. Pajtler, H. Witt, M. Sill, David Jones, V. Hovestadt, Fabian Kratochwil, K. Wani, R. Tatevossian, C. Punchihewa, P. Johann, J. Reimand, H. Warnatz, M. Ryzhova, S. Mack, V. Ramaswamy, D. Capper, L. Schweizer, Laura Sieber, A. Wittmann, Zhiqin Huang, P. Sluis, R. Volckmann, J. Koster, R. Versteeg, D. Fults, H. Toledano, S. Avigad, L. Hoffman, A. Donson, N. Foreman, E. Hewer, K. Zitterbart, M. Gilbert, T. Armstrong, N. Gupta, J. Allen, M. Karajannis, D. Zagzag, M. Hasselblatt, A. Kulozik, O. Witt, V. Collins, K. Hoff, S. Rutkowski, T. Pietsch, Gary Bader, M. Yaspo, A. Deimling, P. Lichter, Michael Taylor, R. Gilbertson, D. Ellison, K. Aldape, A. Korshunov, M. Kool, S. Pfister (2015)

    Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

    Cancer cell, 27 5

  • C Hartmann, B Hentschel, M Tatagiba, J Schramm, O Schnell, C Seidel, R Stein, G Reifenberger, T Pietsch, A Deimling, M Loeffler, M Weller (2011)

    German Glioma Network. Molecular markers in low‐grade gliomas: Predictive or prognostic?

    , 17

  • DJ Brat, RG Verhaak, KD Aldape, WK Yung, SR Salama, LA Cooper, E Rheinbay, CR Miller, M Vitucci, O Morozova, AG Robertson, H Noushmehr, PW Laird, AD Cherniack, R Akbani, JT Huse, G Ciriello, LM Poisson, JS Barnholtz‐Sloan, MS Berger, C Brennan, RR Colen, H Colman, AE Flanders, C Giannini, M Grifford, A Iavarone, R Jain, I Joseph, J Kim, K Kasaian, T Mikkelsen, BA Murray, BP O'Neill, L Pachter, DW Parsons, C Sougnez, EP Sulman, SR Vandenberg, EG Meir, A Deimling, H Zhang, D Crain, K Lau, D Mallery, S Morris, J Paulauskis, R Penny, T Shelton, M Sherman, P Yena, A Black, J Bowen, K Dicostanzo, J Gastier‐Foster, KM Leraas, TM Lichtenberg, CR Pierson, NC Ramirez, C Taylor, S Weaver, L Wise, E Zmuda, T Davidsen, JA Demchok, G Eley, ML Ferguson, CM Hutter, KR Mills Shaw, BA Ozenberger, M Sheth, HJ Sofia, R Tarnuzzer, Z Wang, L Yang, JC Zenklusen, B Ayala, J Baboud, S Chudamani, MA Jensen, J Liu, T Pihl, R Raman, Y Wan, Y Wu, A Ally, JT Auman, M Balasundaram, S Balu, SB Baylin, R Beroukhim, MS Bootwalla, R Bowlby, CA Bristow, D Brooks, Y Butterfield, R Carlsen, S Carter, L Chin, A Chu, E Chuah, K Cibulskis, A Clarke, SG Coetzee, N Dhalla, T Fennell, S Fisher, S Gabriel, G Getz, R Gibbs, R Guin, A Hadjipanayis, DN Hayes, T Hinoue, K Hoadley, RA Holt, AP Hoyle, SR Jefferys, S Jones, CD Jones, R Kucherlapati, PH Lai, E Lander, S Lee, L Lichtenstein, Y Ma, DT Maglinte, HS Mahadeshwar, MA Marra, M Mayo, S Meng, ML Meyerson, PA Mieczkowski, RA Moore, LE Mose, AJ Mungall, A Pantazi, M Parfenov, PJ Park, JS Parker, CM Perou, A Protopopov, X Ren, J Roach, TS Sabedot, J Schein, SE Schumacher, JG Seidman, S Seth, H Shen, JV Simons, P Sipahimalani, MG Soloway, X Song, H Sun, B Tabak, A Tam, D Tan, J Tang, N Thiessen, T Triche, DJ Berg, U Veluvolu, S Waring, DJ Weisenberger, MD Wilkerson, T Wong, J Wu, L Xi, AW Xu, L Yang, TI Zack, J Zhang, BA Aksoy, H Arachchi, C Benz, B Bernard, D Carlin, J Cho, D DiCara, S Frazer, GN Fuller, J Gao, N Gehlenborg, D Haussler, DI Heiman, L Iype, A Jacobsen, Z Ju, S Katzman, H Kim, T Knijnenburg, RB Kreisberg, MS Lawrence, W Lee, K Leinonen, P Lin, S Ling, W Liu, Y Liu, Y Liu, Y Lu, G Mills, S Ng, MS Noble, E Paull, A Rao, S Reynolds, G Saksena, Z Sanborn, C Sander, N Schultz, Y Senbabaoglu, R Shen, I Shmulevich, R Sinha, J Stuart, SO Sumer, Y Sun, N Tasman, BS Taylor, D Voet, N Weinhold, JN Weinstein, D Yang, K Yoshihara, S Zheng, W Zhang, L Zou, T Abel, S Sadeghi, ML Cohen, J Eschbacher, EM Hattab, A Raghunathan, MJ Schniederjan, D Aziz, G Barnett, W Barrett, DD Bigner, L Boice, C Brewer, C Calatozzolo, B Campos, CG Carlotti, TA Chan, L Cuppini, E Curley, S Cuzzubbo, K Devine, F DiMeco, R Duell, JB Elder, A Fehrenbach, G Finocchiaro, W Friedman, J Fulop, J Gardner, B Hermes, C Herold‐Mende, C Jungk, A Kendler, NL Lehman, E Lipp, O Liu, R Mandt, M McGraw, R Mclendon, C McPherson, L Neder, P Nguyen, A Noss, R Nunziata, QT Ostrom, C Palmer, A Perin, B Pollo, A Potapov, O Potapova, WK Rathmell, D Rotin, L Scarpace, C Schilero, K Senecal, K Shimmel, V Shurkhay, S Sifri, R Singh, AE Sloan, K Smolenski, SM Staugaitis, R Steele, L Thorne, DP Tirapelli, A Unterberg, M Vallurupalli, Y Wang, R Warnick, F Williams, Y Wolinsky, S Bell, M Rosenberg, C Stewart, F Huang, JL Grimsby, AJ Radenbaugh, J Zhang (2015)

    Cancer genome atlas research network. Comprehensive, integrative genomic analysis of diffuse lower‐grade gliomas

    , 372

  • D. Meyronet, Maud Esteban-Mader, C. Bonnet, M. Joly, E. Uro-Coste, A. Amiel-Benouaich, Fabien Forest, C. Rousselot-Denis, F. Burel-Vandenbos, V. Bourg, J. Guyotat, T. Fenouil, A. Jouvet, J. Honnorat, F. Ducray (2017)

    Characteristics of H3 K27M-mutant gliomas in adults

    Neuro-Oncology, 19

  • K. Pajtler, S. Mack, V. Ramaswamy, Christian Smith, H. Witt, Amy Smith, J. Hansford, K. Hoff, K. Wright, E. Hwang, D. Frappaz, Y. Kanemura, M. Massimino, C. Faure-Conter, P. Modena, U. Tabori, K. Warren, E. Holland, K. Ichimura, F. Giangaspero, D. Castel, A. Deimling, M. Kool, P. Dirks, R. Grundy, N. Foreman, A. Gajjar, A. Korshunov, J. Finlay, R. Gilbertson, D. Ellison, K. Aldape, T. Merchant, E. Bouffet, S. Pfister, Michael Taylor (2016)

    The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

    Acta Neuropathologica, 133

  • F. Rodriguez, T. Tihan, D. Lin, W. McDonald, J. Nigro, B. Feuerstein, Sadhana Jackson, K. Cohen, P. Burger (2014)

    Clinicopathologic Features of Pediatric Oligodendrogliomas: A Series of 50 Patients

    The American Journal of Surgical Pathology, 38

  • D. Reuss, Yasin Mamatjan, D. Schrimpf, D. Capper, V. Hovestadt, A. Kratz, F. Sahm, C. Koelsche, A. Korshunov, A. Olar, C. Hartmann, J. Reijneveld, P. Wesseling, A. Unterberg, M. Platten, W. Wick, C. Herold‐Mende, K. Aldape, A. Deimling (2015)

    IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO

    Acta Neuropathologica, 129

  • F. Ducray, Y. Marie, M. Sanson (2009)

    IDH1 and IDH2 mutations in gliomas.

    The New England journal of medicine, 360 21

  • J. Eckel-Passow, D. Lachance, A. Molinaro, K. Walsh, P. Decker, H. Sicotte, M. Pekmezci, T. Rice, M. Kosel, I. Smirnov, G. Sarkar, Alissa Caron, T. Kollmeyer, Corinne Praska, A. Chada, C. Halder, H. Hansen, L. McCoy, P. Bracci, Roxanne Marshall, S. Zheng, G. Reis, A. Pico, B. O'neill, J. Buckner, C. Giannini, J. Huse, A. Perry, T. Tihan, M. Berger, Susan Chang, M. Prados, J. Wiemels, J. Wiencke, M. Wrensch, R. Jenkins (2015)

    Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.

    The New England journal of medicine, 372 26

  • V. Collins, David Jones, C. Giannini (2015)

    Pilocytic astrocytoma: pathology, molecular mechanisms and markers

    Acta Neuropathologica, 129

  • D. Louis, Kenneth Aldape, D. Brat, D. Capper, D. Capper, D. Ellison, C. Hawkins, W. Paulus, A. Perry, G. Reifenberger, D. Figarella-Branger, Pieter Wesseling, Pieter Wesseling, T. Batchelor, J. Cairncross, Stefan Pfister, Stefan Pfister, S. Rutkowski, M. Weller, Wolfgang Wick, Wolfgang Wick, A. Deimling (2016)

    Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

    Acta Neuropathologica, 133

  • F. Sahm, D. Reuss, C. Koelsche, D. Capper, J. Schittenhelm, S. Heim, David Jones, S. Pfister, C. Herold‐Mende, W. Wick, W. Mueller, C. Hartmann, W. Paulus, A. Deimling (2014)

    Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

    Acta Neuropathologica, 128

  • D. Solomon, M. Wood, T. Tihan, A. Bollen, N. Gupta, J. Phillips, A. Perry (2016)

    Diffuse Midline Gliomas with Histone H3‐K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations

    Brain Pathology, 26

  • M. Sanson, Y. Marie, S. Paris, A. Idbaih, J. Laffaire, F. Ducray, S. Hallani, B. Boisselier, K. Mokhtari, K. Hoang-Xuan, J. Delattre (2009)

    Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 25

  • U. Herrlinger, David Jones, M. Glas, E. Hattingen, D. Gramatzki, M. Stuplich, J. Felsberg, O. Bähr, G. Gielen, M. Simon, D. Wiewrodt, M. Schabet, V. Hovestadt, D. Capper, J. Steinbach, A. Deimling, P. Lichter, S. Pfister, M. Weller, G. Reifenberger (2016)

    Gliomatosis cerebri: no evidence for a separate brain tumor entity

    Acta Neuropathologica, 131

  • A. Olar, K. Wani, Kristin Alfaro-Munoz, L. Heathcock, H. Thuijl, M. Gilbert, T. Armstrong, E. Sulman, D. Cahill, E. Vera‐Bolanos, Ying Yuan, J. Reijneveld, B. Ylstra, P. Wesseling, K. Aldape (2015)

    IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas

    Acta Neuropathologica, 129

  • D. Reuss, F. Sahm, D. Schrimpf, B. Wiestler, D. Capper, C. Koelsche, L. Schweizer, A. Korshunov, David Jones, V. Hovestadt, M. Mittelbronn, J. Schittenhelm, C. Herold‐Mende, A. Unterberg, M. Platten, M. Weller, W. Wick, S. Pfister, A. Deimling (2014)

    ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

    Acta Neuropathologica, 129

  • B. Kleinschmidt-DeMasters, D. Aisner, D. Birks, N. Foreman (2013)

    Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation

    The American Journal of Surgical Pathology, 37

  • J. Huse, E. Diamond, Lu Wang, M. Rosenblum (2014)

    Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true “oligoastrocytoma”?

    Acta Neuropathologica, 129

  • Jörg Balss, Jochen Meyer, W. Mueller, A. Korshunov, C. Hartmann, A. Deimling (2008)

    Analysis of the IDH1 codon 132 mutation in brain tumors

    Acta Neuropathologica, 116

  • P. Wilcox, Cheryl Li, Maggie Lee, B. Shivalingam, J. Brennan, C. Suter, Kimberley Alexander-Kaufman, T. Lum, M. Buckland (2014)

    Oligoastrocytomas: throwing the baby out with the bathwater?

    Acta Neuropathologica, 129

  • F. Rodriguez, M. Schniederjan, T. Nicolaides, T. Tihan, P. Burger, A. Perry (2015)

    High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)

    Acta Neuropathologica, 129

  • S. Heim, M. Sill, David Jones, A. Vasiljevic, A. Jouvet, M. Fèvre-Montange, P. Wesseling, R. Beschorner, M. Mittelbronn, P. Kohlhof, V. Hovestadt, P. Johann, M. Kool, K. Pajtler, A. Korshunov, V. Ruland, J. Sperveslage, C. Thomas, H. Witt, A. Deimling, W. Paulus, S. Pfister, D. Capper, M. Hasselblatt (2016)

    Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

    Brain Pathology, 26

  • B. Hinrichs, S. Newman, Christina Appin, William Dunn, L. Cooper, R. Pauly, J. Kowalski, M. Rossi, D. Brat (2016)

    Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups

    Acta Neuropathologica Communications, 4

  • M. Labussière, A. Idbaih, X. Wang, Y. Marie, B. Boisselier, C. Falet, S. Paris, J. Laffaire, C. Carpentier, E. Crinière, F. Ducray, S. Hallani, K. Mokhtari, K. Hoang-Xuan, J. Delattre, M. Sanson (2010)

    All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2

    Neurology, 74

Publisher
Wiley
Copyright
Copyright © 2018 British Neuropathological Society
ISSN
0305-1846
eISSN
1365-2990
DOI
10.1111/nan.12432
Publisher site
See Article on Publisher Site

Abstract

Gliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern (‘nondiffuse gliomas’). In the revised fourth edition of the WHO Classification of CNS tumours published in 2016, classification of especially diffuse gliomas has fundamentally changed: for the first time, a large subset of these tumours is now defined based on presence/absence of IDH mutation and 1p/19q codeletion. Following this approach, the diagnosis of (anaplastic) oligoastrocytoma can be expected to largely disappear. Furthermore, in the WHO 2016 Classification gliomatosis cerebri is not an entity anymore but is now considered as a growth pattern. The most important changes in the very diverse group of ‘nondiffuse’ gliomas and neuronal‐glial tumours are the introduction of anaplastic pleomorphic xanthoastrocytoma, of diffuse leptomeningeal glioneuronal tumour and of RELA fusion‐positive ependymoma as entities. In the last part of this review, after very briefly touching upon classification of neuronal, choroid plexus and pineal region tumours, some practical implications and challenges associated with the WHO 2016 Classification of gliomas are discussed.

Journal

Neuropathology & Applied NeurobiologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ;

There are no references for this article.