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A function of huntingtin in guanine nucleotide exchange on Rab11

A function of huntingtin in guanine nucleotide exchange on Rab11 CELLULAR, MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE NEUROREPORT A function of huntingtin in guanine nucleotide exchange on Rab11 a a a a a a Xueyi Li ,Ellen Sapp ,Antonio Valencia ,Kimberly B. Kegel ,Zheng-HongQin ,JonathanAlexander , a a a c b a Nicholas Masso , Patrick Reeves ,James J. Ritch ,Scott Zeitlin ,Neil Aronin and Marian DiFiglia Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School,Charlestown, b c Department of Medicine and Cell Biology,University of Massachusetts Medical School,Worcester, Massachusetts and Department of Neuroscience, University of Virginia School of Medicine,Charlottesville,Virginia,USA Correspondence to Xueyi Li, and Marian DiFiglia, Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital, Harvard Medical School,Charlestown, MA 02129,USA Tel: + 1617 726 8446; fax: + 1617 7261264; e-mail: xli12@partners.org; di¢glia@helix.mgh.Harvard.edu Received14 August 2008; accepted 20 August 2008 DOI:10.1097/WNR.0b013e328315cd4c Huntingtin is ubiquitously expressed and enriched in the brain. compared with normal embryonic stem cells. In brain membranes, Deletion of the huntingtin gene in mice is lethal during early an antibody against huntingtin immunoprecipitated a nucleotide embryonic development. The function of huntingtin is, however, exchange activity on Rab11and huntingtin was coprecipitated with not clear. Here, we report that huntingtin is important for the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroreport Wolters Kluwer Health

A function of huntingtin in guanine nucleotide exchange on Rab11

Neuroreport , Volume 19 (16) – Oct 1, 2008

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References (16)

ISSN
0959-4965
eISSN
1473-558X
DOI
10.1097/WNR.0b013e328315cd4c
pmid
18845944
Publisher site
See Article on Publisher Site

Abstract

CELLULAR, MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE NEUROREPORT A function of huntingtin in guanine nucleotide exchange on Rab11 a a a a a a Xueyi Li ,Ellen Sapp ,Antonio Valencia ,Kimberly B. Kegel ,Zheng-HongQin ,JonathanAlexander , a a a c b a Nicholas Masso , Patrick Reeves ,James J. Ritch ,Scott Zeitlin ,Neil Aronin and Marian DiFiglia Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School,Charlestown, b c Department of Medicine and Cell Biology,University of Massachusetts Medical School,Worcester, Massachusetts and Department of Neuroscience, University of Virginia School of Medicine,Charlottesville,Virginia,USA Correspondence to Xueyi Li, and Marian DiFiglia, Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital, Harvard Medical School,Charlestown, MA 02129,USA Tel: + 1617 726 8446; fax: + 1617 7261264; e-mail: xli12@partners.org; di¢glia@helix.mgh.Harvard.edu Received14 August 2008; accepted 20 August 2008 DOI:10.1097/WNR.0b013e328315cd4c Huntingtin is ubiquitously expressed and enriched in the brain. compared with normal embryonic stem cells. In brain membranes, Deletion of the huntingtin gene in mice is lethal during early an antibody against huntingtin immunoprecipitated a nucleotide embryonic development. The function of huntingtin is, however, exchange activity on Rab11and huntingtin was coprecipitated with not clear. Here, we report that huntingtin is important for the

Journal

NeuroreportWolters Kluwer Health

Published: Oct 1, 2008

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