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heart matters A look at standard medications for LVSD By Maryanne Crowther, RN, APN, ACNP-BC, ANP-BC, CCRN Cardiology Nurse Practitioner � St. Joseph’s Regional Medical Center � Paterson, N.J. Pharmacologic management of left ventricu- When an ACE inhibitor or an ARB Looks like there lar systolic dysfunction (LVSD) is standard can’t be used, a combination of hydralazine are several and evidence-based, prescribed based on the and isosorbide dinitrate may be prescribed drugs to keep patient’s stage of heart failure (HF). Let’s to provide the same balanced vasodilatory me going. I just take a closer look. effect. Hydralazine prevents the tolerance love variety! effects of the nitrate, and nitrate enhances ACE inhibitors the effectiveness of hydralazine. Angiotensin-converting enzyme (ACE) Additionally, a combination of hydralazine inhibitors are the gold standard for treating and nitrate can augment the protective HF. This class of medication lessens neuro- effects of ACE inhibitors or ARBs and hormonal responses and prevents the con- beta-blockers. version of angiotensin I to angiotensin II. Beta-blockers ACE inhibitors also offload fluid and Beta-blockers are a powerful class of med- pressure from the heart and lungs and provide cellular effects that improve ication used in the treatment of LVSD. heart function
Nursing Made Incredibly Easy! – Wolters Kluwer Health
Published: Nov 1, 2009
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