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Amniotic Fluid Phthalate Levels and Male Fetal Gonad Function

Amniotic Fluid Phthalate Levels and Male Fetal Gonad Function Original a rticle Amniotic Fluid Phthalate Levels and Male Fetal  Gonad Function a,b c d Morten Søndergaard Jensen, Ravinder Anand-Ivell, Bent Nørgaard-Pedersen, e f d d e Bo A. G. Jönsson, Jens Peter Bonde, David M. Hougaard, Arieh Cohen, Christian H. Lindh, g h Richard Ivell, and Gunnar Toft cryptorchidism (odds ratio = 1.28 [95% ci = 0.80 to 2.01]) and Background: Prenatal exposure to phthalates may pose a threat to hypospadias (1.69 [0.78 to 3.67]), but was not consistently associ- human male reproduction. However, additional knowledge about the ated with the steroid hormones or insulin-like factor 3. in vivo effect in humans is needed, and reported associations with Conclusions: Data on the DeHP metabolite indicate possible inter - genital abnormalities are inconclusive. We aimed to study prenatal ference with human male fetal gonadal function. considering the di(2-ethylhexyl) phthalate (DeHP) and diisononyl phthalate (DinP) DinP metabolite, we cannot exclude (nor statistically confirm) an exposure in relation to cryptorchidism, hypospadias, and human fetal association with hypospadias and, less strongly, with cryptorchidism. leydig cell function. Methods: We studied 270 cryptorchidism cases, 75 hypospadias (Epidemiology 2015;26: 91–99) cases, and 300 controls. Second-trimester amniotic fluid sam- ples were available from a Danish pregnancy-screening biobank (n = 25,105) covering 1980–1996. We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Epidemiology Wolters Kluwer Health

Amniotic Fluid Phthalate Levels and Male Fetal Gonad Function

Epidemiology , Volume 26 (1) – Jan 1, 2015

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Copyright
Copyright © 2014 by Lippincott Williams & Wilkins
ISSN
1044-3983
eISSN
1531-5487
DOI
10.1097/EDE.0000000000000198
pmid
25384265
Publisher site
See Article on Publisher Site

Abstract

Original a rticle Amniotic Fluid Phthalate Levels and Male Fetal  Gonad Function a,b c d Morten Søndergaard Jensen, Ravinder Anand-Ivell, Bent Nørgaard-Pedersen, e f d d e Bo A. G. Jönsson, Jens Peter Bonde, David M. Hougaard, Arieh Cohen, Christian H. Lindh, g h Richard Ivell, and Gunnar Toft cryptorchidism (odds ratio = 1.28 [95% ci = 0.80 to 2.01]) and Background: Prenatal exposure to phthalates may pose a threat to hypospadias (1.69 [0.78 to 3.67]), but was not consistently associ- human male reproduction. However, additional knowledge about the ated with the steroid hormones or insulin-like factor 3. in vivo effect in humans is needed, and reported associations with Conclusions: Data on the DeHP metabolite indicate possible inter - genital abnormalities are inconclusive. We aimed to study prenatal ference with human male fetal gonadal function. considering the di(2-ethylhexyl) phthalate (DeHP) and diisononyl phthalate (DinP) DinP metabolite, we cannot exclude (nor statistically confirm) an exposure in relation to cryptorchidism, hypospadias, and human fetal association with hypospadias and, less strongly, with cryptorchidism. leydig cell function. Methods: We studied 270 cryptorchidism cases, 75 hypospadias (Epidemiology 2015;26: 91–99) cases, and 300 controls. Second-trimester amniotic fluid sam- ples were available from a Danish pregnancy-screening biobank (n = 25,105) covering 1980–1996. We

Journal

EpidemiologyWolters Kluwer Health

Published: Jan 1, 2015

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