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Animal models in HIV-1 protection and therapy

Animal models in HIV-1 protection and therapy REVIEW URRENT PINION Ann J. Hessell and Nancy L. Haigwood Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies. Keywords animal models, HIV-1, humanized mice, nonhuman primate, simian/human immunodeficiency virus (SHIV), simian immunodeficiency virus (SIV) INTRODUCTION In the first of these, Chahroudi et al. [1] showed that the rates of mother-to-infant transmission in nonpa- As we enter the third decade http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Animal models in HIV-1 protection and therapy

Haigwood, Nancy L.
Current Opinion in HIV and Aids , Volume 10 (3) – May 1, 2015
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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000152
pmid
25730345
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT PINION Ann J. Hessell and Nancy L. Haigwood Purpose of review The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year. Recent findings Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection. Summary Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies. Keywords animal models, HIV-1, humanized mice, nonhuman primate, simian/human immunodeficiency virus (SHIV), simian immunodeficiency virus (SIV) INTRODUCTION In the first of these, Chahroudi et al. [1] showed that the rates of mother-to-infant transmission in nonpa- As we enter the third decade

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Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2015

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