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Antiretroviral therapy in treatment-naı¨ve patients with HIV infection a,b c Ricardo Camacho and Euge ´ nio Teo ´ filo Molecular Biology Laboratory, Centro Hospitalar de Purpose of review Lisboa Ocidental, CMDT/LA, Instituto de Higiene e This review discusses the current status of antiretroviral therapy (ART) in treatment- Medicina Tropical, Universidade Nova de Lisboa and Centro Hospitalar de Lisboa Central, Lisbon, Portugal ¨ naıve patients. ART initiation in such patients needs to be carefully planned, as the aim of therapy has shifted from prolonging life to ensuring maintained adherence to ART and Correspondence to Euge ´ nio Teo ´ filo, Centro Hospitalar de Lisboa Central, Servic ¸o de Medicina 2.3, 1169-050 optimization of quality of life. There is a plethora of first-line antiretroviral agents available, Lisbon, Portugal and physicians must consider several patient-related and therapy-related factors before Tel: +351 213136300 x 21443; fax: +351 213158612; e-mail: eteofilo@gmail.com selecting the most appropriate initial ART. Recent findings Current Opinion in HIV and AIDS 2011, 6 (suppl 1):S3 – S11 Current treatment guidelines recommend the use of nonnucleoside reverse transcriptase inhibitor (NNRTI), ritonavir-boosted protease inhibitor (PI), or integrase strand transfer inhibitor (INSTI)-based regimens in treatment-naı¨ve patients. Treatment selection and modification to achieve optimal
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Dec 1, 2011
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