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Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia

Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia ORIGINAL ARTICLE Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia Mindaugas Andrulis, MD,* Roland Penzel, PhD,* Wilko Weichert, MD,* Andreas von Deimling, MD,wz and David Capper, MDwz morphology, pancytopenia, and small number of circulating Abstract: In recent times BRAF V600E mutations have emerged leukemic B cells. In contrast to other B-cell malignancies, 9,14 as a genetic hallmark of hairy cell leukemia (HCL). This specific HCL has a particularly stable genome andnorecurrent 17 19 point mutation is present in virtually all cases of HCL but is chromosomal translocations. Recently, Tiacci et al de- exceedingly rare in other peripheral B-cell neoplasms. In this scribed activating BRAF V600E mutations in virtually all study we investigated the application of a BRAF V600E mu- cases of HCL, implying that this mutation is a unifying tation-specific antibody (clone VE1) to differentiate HCL from molecular event in the pathogenesis of HCL. Three con- HCL mimics, such as HCL variant and splenic marginal zone secutive studies confirmed the presence of BRAF mutations 1–3,19 lymphoma. A total of 52 routinely processed formalin-fixed in all investigated HCL cases, whereas no mutations paraffin-embedded tissue specimens were investigated (bone were detected in the vast majority http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia

American Journal of Surgical Pathology , Volume 36 (12) – Dec 1, 2012

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References (21)

Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e3182549b50
pmid
22531170
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia Mindaugas Andrulis, MD,* Roland Penzel, PhD,* Wilko Weichert, MD,* Andreas von Deimling, MD,wz and David Capper, MDwz morphology, pancytopenia, and small number of circulating Abstract: In recent times BRAF V600E mutations have emerged leukemic B cells. In contrast to other B-cell malignancies, 9,14 as a genetic hallmark of hairy cell leukemia (HCL). This specific HCL has a particularly stable genome andnorecurrent 17 19 point mutation is present in virtually all cases of HCL but is chromosomal translocations. Recently, Tiacci et al de- exceedingly rare in other peripheral B-cell neoplasms. In this scribed activating BRAF V600E mutations in virtually all study we investigated the application of a BRAF V600E mu- cases of HCL, implying that this mutation is a unifying tation-specific antibody (clone VE1) to differentiate HCL from molecular event in the pathogenesis of HCL. Three con- HCL mimics, such as HCL variant and splenic marginal zone secutive studies confirmed the presence of BRAF mutations 1–3,19 lymphoma. A total of 52 routinely processed formalin-fixed in all investigated HCL cases, whereas no mutations paraffin-embedded tissue specimens were investigated (bone were detected in the vast majority

Journal

American Journal of Surgical PathologyWolters Kluwer Health

Published: Dec 1, 2012

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