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Association of EPAS1

Association of EPAS1 Brief Repotr Association of EPAS1 Gene rs4953354 Polymorphism  with Susceptibility to Lung Adenocarcinoma in  Female Japanese Non-Smokers Shinichi Iwamoto, MD,* Keiji Tanimoto, DDS, PhD,† Yumi Nishio, PhD,* Andika Chandra Putra, MD, PhD,† Hiroshi Fuchita, MS,* Miki Ohe, MD, PhD,* Akihisa Sutani, MD, PhD,* Takashige Kuraki, MD, PhD,* Keiko Hiyama, MD, PhD,‡ Isao Murakami, MD, PhD,§ Hidetaka Eguchi, PhD,║ and Takeshi Isobe, MD, PhD* Key Words: Lung adenocarcinoma, EPAS1, HIF-2α, SNP. Introduction: Hypoxia-inducible factor-2α (also called endothelial periodic acid–Schiff domain protein 1 [EPAS1]) seems to play an (J Thorac Oncol. 2014;9: 1709–1713) important role in some carcinogenesis, though there is no informa- tion on the relationship between single nucleotide polymorphism of EPAS1 and lung cancer development. The aim of this study was to valuation of the genetic factors underlying the develop- explore a possible association of the EPAS1 gene rs4953354 poly- Ement of lung cancer can elucidate the etiology of the dis- morphism with susceptibility to lung cancer. ease and identify high-risk individuals for targeted screening Methods: A case–control study of 346 patients with non–small- and/or prevention. cell lung carcinoma (adenocarcinoma = 249, squamous cell carci- The transcription factor hypoxia-inducible factor-α noma = 97) and 247 healthy control subjects was carried out. A/G (HIF-α) plays an important role in the regulation of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Association of EPAS1

Isobe, Takeshi
Journal of Thoracic Oncology , Volume 9 (11) – Nov 1, 2014
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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000309
pmid
25436804
Publisher site
See Article on Publisher Site

Abstract

Brief Repotr Association of EPAS1 Gene rs4953354 Polymorphism  with Susceptibility to Lung Adenocarcinoma in  Female Japanese Non-Smokers Shinichi Iwamoto, MD,* Keiji Tanimoto, DDS, PhD,† Yumi Nishio, PhD,* Andika Chandra Putra, MD, PhD,† Hiroshi Fuchita, MS,* Miki Ohe, MD, PhD,* Akihisa Sutani, MD, PhD,* Takashige Kuraki, MD, PhD,* Keiko Hiyama, MD, PhD,‡ Isao Murakami, MD, PhD,§ Hidetaka Eguchi, PhD,║ and Takeshi Isobe, MD, PhD* Key Words: Lung adenocarcinoma, EPAS1, HIF-2α, SNP. Introduction: Hypoxia-inducible factor-2α (also called endothelial periodic acid–Schiff domain protein 1 [EPAS1]) seems to play an (J Thorac Oncol. 2014;9: 1709–1713) important role in some carcinogenesis, though there is no informa- tion on the relationship between single nucleotide polymorphism of EPAS1 and lung cancer development. The aim of this study was to valuation of the genetic factors underlying the develop- explore a possible association of the EPAS1 gene rs4953354 poly- Ement of lung cancer can elucidate the etiology of the dis- morphism with susceptibility to lung cancer. ease and identify high-risk individuals for targeted screening Methods: A case–control study of 346 patients with non–small- and/or prevention. cell lung carcinoma (adenocarcinoma = 249, squamous cell carci- The transcription factor hypoxia-inducible factor-α noma = 97) and 247 healthy control subjects was carried out. A/G (HIF-α) plays an important role in the regulation of

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Nov 1, 2014

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