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BRAF

BRAF ORIGINAL CONTRIBUTION BRAF Mutations in Colorectal Cancer Are Associated With Distinct Clinical Characteristics and Worse Prognosis 1,2 1,2 Matthew F. Kalady, M.D.  Kathryn L. DeJulius, B.A., M.S. 1 3 Julian A. Sanchez, M.D.  Awad Jarrar, M.D.  Xiuli Liu, M.D., Ph.D. 1 4 1 Elena Manilich, Ph.D.  Marek Skacel, M.D.  James M. Church, M.B., Ch.B. 1 Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 2 Cancer Biology Department, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 3 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 4 Dahl-Chase Pathology Associates, Bangor, Maine BACKGROUND: Colorectal cancer is a heterogeneous Kaplan-Meier estimates and multivariate Cox regression disease with multiple underlying genetic mutations analysis were performed for overall survival. causing different clinical phenotypes. Mutation in the RESULTS: Four hundred seventy-five colorectal BRAF oncogene is a key step in malignant transformation adenocarcinomas were included in the study population; within the methylator pathway to colorectal cancer. 56 samples harbored a BRAF mutation (12%). There However, there is a paucity of information about BRAF were significant differences between BRAF wild-type and mutant colorectal tumors. mutant tumors in age (66 vs 75 years, p  0.004), female OBJECTIVE: This study defines http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diseases of the Colon & Rectum Wolters Kluwer Health

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Copyright
© The ASCRS 2012
ISSN
0012-3706
eISSN
1530-0358
DOI
10.1097/DCR.0b013e31823c08b3
pmid
22228154
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION BRAF Mutations in Colorectal Cancer Are Associated With Distinct Clinical Characteristics and Worse Prognosis 1,2 1,2 Matthew F. Kalady, M.D.  Kathryn L. DeJulius, B.A., M.S. 1 3 Julian A. Sanchez, M.D.  Awad Jarrar, M.D.  Xiuli Liu, M.D., Ph.D. 1 4 1 Elena Manilich, Ph.D.  Marek Skacel, M.D.  James M. Church, M.B., Ch.B. 1 Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 2 Cancer Biology Department, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 3 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 4 Dahl-Chase Pathology Associates, Bangor, Maine BACKGROUND: Colorectal cancer is a heterogeneous Kaplan-Meier estimates and multivariate Cox regression disease with multiple underlying genetic mutations analysis were performed for overall survival. causing different clinical phenotypes. Mutation in the RESULTS: Four hundred seventy-five colorectal BRAF oncogene is a key step in malignant transformation adenocarcinomas were included in the study population; within the methylator pathway to colorectal cancer. 56 samples harbored a BRAF mutation (12%). There However, there is a paucity of information about BRAF were significant differences between BRAF wild-type and mutant colorectal tumors. mutant tumors in age (66 vs 75 years, p  0.004), female OBJECTIVE: This study defines

Journal

Diseases of the Colon & RectumWolters Kluwer Health

Published: Feb 1, 2012

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