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Branched-chain amino acids as biomarkers in diabetes

Branched-chain amino acids as biomarkers in diabetes Downloaded from http://journals.lww.com/co-clinicalnutrition by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/04/2020 REVIEW URRENT Branched-chain amino acids as biomarkers PINION in diabetes Pieter Giesbertz and Hannelore Daniel Purpose of review Numerous human studies have consistently demonstrated that concentrations of branched-chain amino acids (BCAAs) in plasma and urine are associated with insulin resistance and have the quality to predict diabetes development. However, it is not known how altered BCAA levels link to insulin action and diabetes. This review addresses some recent findings in BCAA metabolism and discusses their role as reporter molecules of insulin sensitivity and diabetes and their possible contribution to disease progression. Recent findings Changes in plasma and urine levels result mainly from altered metabolism in tissues and recent studies have thus focused on organ-specific changes in BCAA handling using animal models and human tissue samples. A decreased mitochondrial oxidation has been demonstrated in peripheral tissues and that was shown to be associated with an increased inflammatory tone and changes in adipokine levels (adiponectin and leptin). These changes appear already before insulin resistance is established. Key findings demonstrating the discordance between changes in BCAA and insulin resistance are derived from studies using insulin sensitizers and from data collected in patients undergoing Roux-en-Y bypass http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Clinical Nutrition & Metabolic Care Wolters Kluwer Health

Branched-chain amino acids as biomarkers in diabetes

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References (66)

Publisher
Wolters Kluwer Health
ISSN
1363-1950
eISSN
1473-6519
DOI
10.1097/MCO.0000000000000235
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/co-clinicalnutrition by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/04/2020 REVIEW URRENT Branched-chain amino acids as biomarkers PINION in diabetes Pieter Giesbertz and Hannelore Daniel Purpose of review Numerous human studies have consistently demonstrated that concentrations of branched-chain amino acids (BCAAs) in plasma and urine are associated with insulin resistance and have the quality to predict diabetes development. However, it is not known how altered BCAA levels link to insulin action and diabetes. This review addresses some recent findings in BCAA metabolism and discusses their role as reporter molecules of insulin sensitivity and diabetes and their possible contribution to disease progression. Recent findings Changes in plasma and urine levels result mainly from altered metabolism in tissues and recent studies have thus focused on organ-specific changes in BCAA handling using animal models and human tissue samples. A decreased mitochondrial oxidation has been demonstrated in peripheral tissues and that was shown to be associated with an increased inflammatory tone and changes in adipokine levels (adiponectin and leptin). These changes appear already before insulin resistance is established. Key findings demonstrating the discordance between changes in BCAA and insulin resistance are derived from studies using insulin sensitizers and from data collected in patients undergoing Roux-en-Y bypass

Journal

Current Opinion in Clinical Nutrition & Metabolic CareWolters Kluwer Health

Published: Jan 1, 2016

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