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BRCA A Distinct Clinical Phenotype?

BRCA A Distinct Clinical Phenotype? BRCA-Mutation–Associated Fallopian Tube Carcinoma A Distinct Clinical Phenotype? Ilana Cass, MD, Christine Holschneider, MD, Nandini Datta, MD, Denise Barbuto, MD, PhD, Ann E. Walts, MD, and Beth Y. Karlan, MD OBJECTIVE: To compare clinical and histologic features proximal disease. Occult fallopian tube cancer diagnosed between fallopian tube cancers in women with germline at prophylactic surgery in BRCA mutation carriers was BRCA mutations and sporadic cases. exclusively distal. “Skip” areas of high-grade dysplasia were only seen in 2 patients, both of whom were BRCA METHODS: Twenty-eight patients with fallopian tube mutation carriers. There were no differences in the cancer had BRCA mutation testing using multiplex poly- immunohistochemical staining for p53, ki67, estrogen merase chain reaction and protein truncation testing. receptor or progesterone receptor in carcinomas and Histologic slides were reviewed by 2 pathologists, and dysplastic or benign epithelia of patients with or without immunohistochemical staining for p53, ki67, estrogen BRCA mutations. Overexpression of p53 was commonly receptor, and progesterone receptor was performed on seen in fallopian tube cancers and dysplastic epithelium, carcinomas and dysplastic and benign tubal epithelia. but rarely noted in benign epithelium. RESULTS: Twelve of 28 (43%) women had BRCA muta- tions: 11 BRCA1, 1 BRCA2. Excluding 4 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obstetrics & Gynecology Wolters Kluwer Health

BRCA A Distinct Clinical Phenotype?

Obstetrics & Gynecology , Volume 106 (6) – Dec 1, 2005

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ISSN
0029-7844
eISSN
1873-233X
DOI
10.1097/01.AOG.0000187892.78392.3f
pmid
16319259
Publisher site
See Article on Publisher Site

Abstract

BRCA-Mutation–Associated Fallopian Tube Carcinoma A Distinct Clinical Phenotype? Ilana Cass, MD, Christine Holschneider, MD, Nandini Datta, MD, Denise Barbuto, MD, PhD, Ann E. Walts, MD, and Beth Y. Karlan, MD OBJECTIVE: To compare clinical and histologic features proximal disease. Occult fallopian tube cancer diagnosed between fallopian tube cancers in women with germline at prophylactic surgery in BRCA mutation carriers was BRCA mutations and sporadic cases. exclusively distal. “Skip” areas of high-grade dysplasia were only seen in 2 patients, both of whom were BRCA METHODS: Twenty-eight patients with fallopian tube mutation carriers. There were no differences in the cancer had BRCA mutation testing using multiplex poly- immunohistochemical staining for p53, ki67, estrogen merase chain reaction and protein truncation testing. receptor or progesterone receptor in carcinomas and Histologic slides were reviewed by 2 pathologists, and dysplastic or benign epithelia of patients with or without immunohistochemical staining for p53, ki67, estrogen BRCA mutations. Overexpression of p53 was commonly receptor, and progesterone receptor was performed on seen in fallopian tube cancers and dysplastic epithelium, carcinomas and dysplastic and benign tubal epithelia. but rarely noted in benign epithelium. RESULTS: Twelve of 28 (43%) women had BRCA muta- tions: 11 BRCA1, 1 BRCA2. Excluding 4

Journal

Obstetrics & GynecologyWolters Kluwer Health

Published: Dec 1, 2005

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