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Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design

Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design a b c Christian Brander , Steve Self and Bette Korber Purpose of review Introduction HIV diversity is a major challenge to accurate detection of Global HIV diversity represents a serious complication in HIV-specific immunity in vitro and HIV vaccine immunogen the design of a vaccine that could mediate broad protec- design alike. Although achieving extensive coverage of tion from the spectrum of circulating viruses. Sequence global viral diversity is a common goal for both tasks, diversity also has an impact on ability to assess immune different strategies for achieving maximal in-vitro detection responses elicited upon natural infection reliably using of responses and optimal in-vivo induction of immune in-vitro assays, and consequently it prevents truly reliable responses may be needed. This review describes and definition of correlates of immune protection [1,2]. compares some of the most recently developed approaches. A number of in-vitro approaches have recently been Recent findings developed that aim to detect cellular immune responses Single sequence-based antigen sets as well as polyvalent more comprehensively and, in at least some cases, these peptide test reagents have been developed over recent have improved the in-vitro detection http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design

Korber, Bette
Current Opinion in HIV and Aids , Volume 2 (3) – May 1, 2007
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3280f3bfe2
pmid
19372885
Publisher site
See Article on Publisher Site

Abstract

Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design a b c Christian Brander , Steve Self and Bette Korber Purpose of review Introduction HIV diversity is a major challenge to accurate detection of Global HIV diversity represents a serious complication in HIV-specific immunity in vitro and HIV vaccine immunogen the design of a vaccine that could mediate broad protec- design alike. Although achieving extensive coverage of tion from the spectrum of circulating viruses. Sequence global viral diversity is a common goal for both tasks, diversity also has an impact on ability to assess immune different strategies for achieving maximal in-vitro detection responses elicited upon natural infection reliably using of responses and optimal in-vivo induction of immune in-vitro assays, and consequently it prevents truly reliable responses may be needed. This review describes and definition of correlates of immune protection [1,2]. compares some of the most recently developed approaches. A number of in-vitro approaches have recently been Recent findings developed that aim to detect cellular immune responses Single sequence-based antigen sets as well as polyvalent more comprehensively and, in at least some cases, these peptide test reagents have been developed over recent have improved the in-vitro detection

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2007

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