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Changing causes of mortality in patients with familial adenomatous polyposis

Changing causes of mortality in patients with familial adenomatous polyposis Changing Causes of Mortality in Patients with Familial Adenomatous Polyposis Lance A. Belchetz, M.D., Theresa Berk, M.S.S.A., Bharati V. Bapat, Ph.D., Zane Cohen, M.D., Steven Gallinger, M.D. From the Steve Atanas Stavro Familial Gastrointestinal Cancer Registry, Departments of Surgery and Pathology, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada Widespread use of prophylactic colectomy has resulted in a pigment epithelium, gastric and duodenal tumors, en- reduction in the incidence of colorectal cancer in familial docrine adenomas, brain tumors, and desmoid tu- adenomatous polyposis (FAP) patients. A retrospective mors. 3-5 chart review of families registered at the Steve Atanas Stavro Familial Gastrointestinal Cancer Registry in Toronto was As a result of the autosomal dominant nature of this performed to determine whether the decrease in the num- disease and the various phenotypes with which pa- ber of patients developing colorectal cancer implies that tients present, early diagnosis, treatment and careful causes of mortality in FAP patients are shifting to that of extracolonic manifestations of FAP. Information was avail- follow-up of high-risk patients are essential. Develop- able on 140 deaths within 158 families and among 461 ment of FAP registries, in which pedigrees are con- individuals with FAP. When stratified http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diseases of the Colon & Rectum Wolters Kluwer Health

Changing causes of mortality in patients with familial adenomatous polyposis

Diseases of the Colon & Rectum , Volume 39 (4) – Apr 1, 1996

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References (18)

Copyright
© 1996 American Society of Colon and Rectal Surgeons
ISSN
0012-3706
eISSN
1530-0358
DOI
10.1007/BF02054051
Publisher site
See Article on Publisher Site

Abstract

Changing Causes of Mortality in Patients with Familial Adenomatous Polyposis Lance A. Belchetz, M.D., Theresa Berk, M.S.S.A., Bharati V. Bapat, Ph.D., Zane Cohen, M.D., Steven Gallinger, M.D. From the Steve Atanas Stavro Familial Gastrointestinal Cancer Registry, Departments of Surgery and Pathology, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada Widespread use of prophylactic colectomy has resulted in a pigment epithelium, gastric and duodenal tumors, en- reduction in the incidence of colorectal cancer in familial docrine adenomas, brain tumors, and desmoid tu- adenomatous polyposis (FAP) patients. A retrospective mors. 3-5 chart review of families registered at the Steve Atanas Stavro Familial Gastrointestinal Cancer Registry in Toronto was As a result of the autosomal dominant nature of this performed to determine whether the decrease in the num- disease and the various phenotypes with which pa- ber of patients developing colorectal cancer implies that tients present, early diagnosis, treatment and careful causes of mortality in FAP patients are shifting to that of extracolonic manifestations of FAP. Information was avail- follow-up of high-risk patients are essential. Develop- able on 140 deaths within 158 families and among 461 ment of FAP registries, in which pedigrees are con- individuals with FAP. When stratified

Journal

Diseases of the Colon & RectumWolters Kluwer Health

Published: Apr 1, 1996

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