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STATE OF THE ART: CONCISE REVIEW Chemotherapeutic and Targeted Strategies for Locally Advanced and Metastatic Esophageal Cancer Patrick M. Forde, MD and Ronan J. Kelly, MD, MBA highest incidence of esophageal cancer is in Asia and eastern Introduction: Esophageal cancer represents a major health care and southern Africa. In some areas of China, reported inci- problem worldwide and its prevalence is rapidly increasing. A key dence rates are 10- to 100-fold more than the incidence in the challenge in the treatment of both locally advanced and metastatic United States. The principle histologic types of esophageal disease is to improve our understanding of the underlying molecular cancer are esophageal squamous cell carcinoma (ESCC) and biology. Herein we discuss the most active chemotherapies and tar- esophageal adenocarcinoma (EAC). The relative frequency of geted agents for esophageal cancer, and explore potential differences histologic subtypes differs greatly by geographical location. in the disease between Eastern and Western countries. Over the last 30 years in Western Europe, North America, and Methods: We reviewed the literature for trials involving chemother- Australia, there has been a dramatic shift in the histological apy and targeted agents in locally advanced and metastatic disease 4,5 subtypes from squamous cell to adenocarcinoma. This has in the last 20 years.
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jun 1, 2013
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