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Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a Prognostic Role for HER2

Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a... ORIGINAL ARTICLE Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a Prognostic Role for HER2 Gene Copy Number in Female Patients Samer Al-Saad, MD, PhD,*† Khalid Al-Shibli, MD, PhD,*‡ Tom Donnem, MD, PhD,§ Sigve Andersen, MD,§ Roy M. Bremnes, MD,§ and Lill-Tove Busund, MD, PhD*† Key Words: Erb family members, HER2, SISH, Prognosis, Tissue Introduction: To compare the efficacy of silver in situ hybridization microarray, NSCLC. (SISH) and immunohistochemistry (IHC) in detecting HER2 alter- (J Thorac Oncol. 2010;5: 1536–1543) ations and to investigate the prevalence and prognostic significance of Erb family members in non-small cell lung cancer (NSCLC). Methods: Stage I to IIIA tumors from 335 patients with NSCLC olecular factors are gaining ground as prognosticators were immunohistochemically tested for protein expression of all Erb Mand as useful therapeutic targets against lung carci- family members. Membranous HER2 expression was compared noma, the malignancy with the highest mortality. In lung with its gene copy number by SISH in paraffin-embedded, formalin- cancer, the tyrosine kinase Erb family receptors are of great fixed material. Correlations were made with clinicopathological 2– 4 clinical research interest. variables. The human epidermal growth factor receptor (Erb) Results: Synchronous high immunohistochemical expression http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a Prognostic Role for HER2

Busund, Lill-Tove
Journal of Thoracic Oncology , Volume 5 (10) – Oct 1, 2010
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References (53)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181ea510a
pmid
20802349
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Clinical Significance of Epidermal Growth Factor Receptors in Non-small Cell Lung Cancer and a Prognostic Role for HER2 Gene Copy Number in Female Patients Samer Al-Saad, MD, PhD,*† Khalid Al-Shibli, MD, PhD,*‡ Tom Donnem, MD, PhD,§ Sigve Andersen, MD,§ Roy M. Bremnes, MD,§ and Lill-Tove Busund, MD, PhD*† Key Words: Erb family members, HER2, SISH, Prognosis, Tissue Introduction: To compare the efficacy of silver in situ hybridization microarray, NSCLC. (SISH) and immunohistochemistry (IHC) in detecting HER2 alter- (J Thorac Oncol. 2010;5: 1536–1543) ations and to investigate the prevalence and prognostic significance of Erb family members in non-small cell lung cancer (NSCLC). Methods: Stage I to IIIA tumors from 335 patients with NSCLC olecular factors are gaining ground as prognosticators were immunohistochemically tested for protein expression of all Erb Mand as useful therapeutic targets against lung carci- family members. Membranous HER2 expression was compared noma, the malignancy with the highest mortality. In lung with its gene copy number by SISH in paraffin-embedded, formalin- cancer, the tyrosine kinase Erb family receptors are of great fixed material. Correlations were made with clinicopathological 2– 4 clinical research interest. variables. The human epidermal growth factor receptor (Erb) Results: Synchronous high immunohistochemical expression

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Oct 1, 2010

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