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Combined BRAF V600E

Combined BRAF V600E ORIGINAL ARTICLE V600E Combined BRAF -positive Melanocytic Lesions With Large Epithelioid Cells Lacking BAP1 Expression and Conventional Nevomelanocytes Klaus J. Busam, MD,* Joanne Sung, MD,w Thomas Wiesner, MD,z Andreas von Deimling, MD,y8 and Achim Jungbluth, MDz Key Words: spitz nevus, BAP1, BRAF, combined nevus, im- Abstract: Recently a group of spitzoid melanocytic pro- munohistochemistry liferations with loss of BAP1 expression has been reported. The (Am J Surg Pathol 2013;37:193–199) lesions may occur sporadically or as part of a familial cancer syndrome. They have distinct histopathologic features charac- terized by a nevus-like silhouette and cytologic composition of large epithelioid melanocytes with oval vesicular nuclei, distinct he distinction of Spitz nevus from melanoma and the nucleoli, and abundant cytoplasm with well-defined cytoplasmic Tnature of spitzoid melanocytic proliferations with borders. A characteristic immunohistochemical finding is loss of features intermediate between a nevus and a melanoma nuclear labeling for BAP1. In contrast to classic Spitz nevi, the V600E [so-called “atypical Spitz tumors” (ASTs)] is a known lesions carry the BRAF mutation. They may present as a 1–4 problem area in dermatopathology. Recently, a mor- pure large epithelioid cell proliferation or as a combined lesion in phologically distinct variant in the spectrum of Spitz http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

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Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e318263648c
pmid
23026932
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE V600E Combined BRAF -positive Melanocytic Lesions With Large Epithelioid Cells Lacking BAP1 Expression and Conventional Nevomelanocytes Klaus J. Busam, MD,* Joanne Sung, MD,w Thomas Wiesner, MD,z Andreas von Deimling, MD,y8 and Achim Jungbluth, MDz Key Words: spitz nevus, BAP1, BRAF, combined nevus, im- Abstract: Recently a group of spitzoid melanocytic pro- munohistochemistry liferations with loss of BAP1 expression has been reported. The (Am J Surg Pathol 2013;37:193–199) lesions may occur sporadically or as part of a familial cancer syndrome. They have distinct histopathologic features charac- terized by a nevus-like silhouette and cytologic composition of large epithelioid melanocytes with oval vesicular nuclei, distinct he distinction of Spitz nevus from melanoma and the nucleoli, and abundant cytoplasm with well-defined cytoplasmic Tnature of spitzoid melanocytic proliferations with borders. A characteristic immunohistochemical finding is loss of features intermediate between a nevus and a melanoma nuclear labeling for BAP1. In contrast to classic Spitz nevi, the V600E [so-called “atypical Spitz tumors” (ASTs)] is a known lesions carry the BRAF mutation. They may present as a 1–4 problem area in dermatopathology. Recently, a mor- pure large epithelioid cell proliferation or as a combined lesion in phologically distinct variant in the spectrum of Spitz

Journal

American Journal of Surgical PathologyWolters Kluwer Health

Published: Feb 1, 2013

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