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Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites

Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small... ORIGINAL ARTICLE Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites Cecilia Bozzetti, PhD,* Marcello Tiseo, MD,* Costanza Lagrasta, PhD,† Rita Nizzoli, PhD,* Annamaria Guazzi, PhD,* Francesco Leonardi, MD,* Donatello Gasparro, MD,* Elena Spiritelli, MD,* Michele Rusca, MD,‡ Paolo Carbognani, MD,‡ Maria Majori, MD,§ Vittorio Franciosi, MD,* Guido Rindi, MD, PhD,† and Andrea Ardizzoni, MD* Key Words: NSCLC, EGFR, FISH, Primary tumor, Metastasis. Purpose: Epidermal growth factor receptor (EGFR) gene copy number obtained by fluorescence in situ hybridization (FISH) has (J Thorac Oncol. 2008;3: 18–22) been recently found to predict treatment outcome in non-small cell lung cancer (NSCLC) patients receiving EGFR tyrosine kinase inhibitors. However, it is still unknown whether EGFR status differs pproximately one third of all cancer-related deaths in in metastases compared with primary NSCLC. In all studies FISH AWestern countries are because of lung cancer. Non-small have been performed on histologic material. The possibility to cell lung cancer (NSCLC) represents 75 to 80% of lung perform FISH analysis on cytologic material obtained by fine-needle cancer cases and accounts for approximately 1.2 million new aspiration from superficial and visceral metastases would allow http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites

Ardizzoni, Andrea
Journal of Thoracic Oncology , Volume 3 (1) – Jan 1, 2008
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e31815e8ba2
pmid
18166836
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Comparison Between Epidermal Growth Factor Receptor (EGFR) Gene Expression in Primary Non-small Cell Lung Cancer (NSCLC) and in Fine-Needle Aspirates from Distant Metastatic Sites Cecilia Bozzetti, PhD,* Marcello Tiseo, MD,* Costanza Lagrasta, PhD,† Rita Nizzoli, PhD,* Annamaria Guazzi, PhD,* Francesco Leonardi, MD,* Donatello Gasparro, MD,* Elena Spiritelli, MD,* Michele Rusca, MD,‡ Paolo Carbognani, MD,‡ Maria Majori, MD,§ Vittorio Franciosi, MD,* Guido Rindi, MD, PhD,† and Andrea Ardizzoni, MD* Key Words: NSCLC, EGFR, FISH, Primary tumor, Metastasis. Purpose: Epidermal growth factor receptor (EGFR) gene copy number obtained by fluorescence in situ hybridization (FISH) has (J Thorac Oncol. 2008;3: 18–22) been recently found to predict treatment outcome in non-small cell lung cancer (NSCLC) patients receiving EGFR tyrosine kinase inhibitors. However, it is still unknown whether EGFR status differs pproximately one third of all cancer-related deaths in in metastases compared with primary NSCLC. In all studies FISH AWestern countries are because of lung cancer. Non-small have been performed on histologic material. The possibility to cell lung cancer (NSCLC) represents 75 to 80% of lung perform FISH analysis on cytologic material obtained by fine-needle cancer cases and accounts for approximately 1.2 million new aspiration from superficial and visceral metastases would allow

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jan 1, 2008

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