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Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung

Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the... ORIGINAL ARTICLE Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung Hidetaka Uramoto, PhD, MD, Tomoko So, PhD, MD, Yoshika Nagata, PhD, MD, Koji Kuroda, PhD, MD, Yoshiki Shigematsu, PhD, MD, Tetsuro Baba, PhD, MD, Tetsuya So, PhD, MD, Mitsuhiro Takenoyama, PhD, MD, Takeshi Hanagiri, PhD, MD, and Kosei Yasumoto, PhD, MD ung cancer is the most common cause of cancer death in Introduction: The identification of activating mutations in the Lthe majority of developed countries. The absolute number epidermal growth factor receptor (EGFR) gene is one of the most of patients with lung cancer is still increasing worldwide. intriguing recent discoveries in the field of lung cancer research, and Despite advances in therapeutic modalities, the prognosis of they are more commonly found in adenocarcinoma occurring in 3,4 lung cancer is poor. In particular, the patients with ad- females, never/light smokers, and East Asian patients. Why such vanced-stage disease experienced a high mortality rate de- certain patients are susceptible to the development of EGFR-mutant 4 spite multidisciplinary treatment. Therefore, the develop- tumors is currently unknown. ment of new modalities such as molecular target therapy is Methods: This study evaluated the medical records of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung

Journal of Thoracic Oncology , Volume 5 (8) – Aug 1, 2010

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References (51)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181e0b993
pmid
20548248
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung Hidetaka Uramoto, PhD, MD, Tomoko So, PhD, MD, Yoshika Nagata, PhD, MD, Koji Kuroda, PhD, MD, Yoshiki Shigematsu, PhD, MD, Tetsuro Baba, PhD, MD, Tetsuya So, PhD, MD, Mitsuhiro Takenoyama, PhD, MD, Takeshi Hanagiri, PhD, MD, and Kosei Yasumoto, PhD, MD ung cancer is the most common cause of cancer death in Introduction: The identification of activating mutations in the Lthe majority of developed countries. The absolute number epidermal growth factor receptor (EGFR) gene is one of the most of patients with lung cancer is still increasing worldwide. intriguing recent discoveries in the field of lung cancer research, and Despite advances in therapeutic modalities, the prognosis of they are more commonly found in adenocarcinoma occurring in 3,4 lung cancer is poor. In particular, the patients with ad- females, never/light smokers, and East Asian patients. Why such vanced-stage disease experienced a high mortality rate de- certain patients are susceptible to the development of EGFR-mutant 4 spite multidisciplinary treatment. Therefore, the develop- tumors is currently unknown. ment of new modalities such as molecular target therapy is Methods: This study evaluated the medical records of

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Aug 1, 2010

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