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Corticosteroids and HIV infection: a review of experience

Corticosteroids and HIV infection: a review of experience Corticosteroids and HIV infection: a review of experience Robert S. Wallis Purpose of review Introduction Apoptosis caused by immune activation is thought to be an Corticosteroids exert broad inhibitory effects on both important mechanism for progressive CD4 T-cell depletion innate and acquired immunity, affecting T and B cells, in HIV disease. This review examines published literature on monocytes, and neutrophils. As a result, they have the effects of corticosteroids on activation markers and become first-line agents in the short-term management disease indicators in HIV. of a wide range of inflammatory, autoimmune, and aller- Recent findings gic conditions. Corticosteroids also play important Salutary effects were noted on activation markers, adjunctive therapeutic roles in certain infections in which apoptosis and circulating CD4 T-cell numbers in studies in the deleterious effects of the host immune response are which corticosteroids were administered together with prominent. Corticosteroids have been studied in HIV antiretroviral therapy. Safety concerns regarding infection, both to manage coincident inflammatory and osteonecrosis of the hip have limited further research in this infectious processes, and to determine effects on HIV area. Controlled trials in which corticosteroids were pathogenesis. Concerns regarding long-term metabolic administered in the absence of antiretroviral therapy have sequelae have, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Corticosteroids and HIV infection: a review of experience

Wallis, Robert S
Current Opinion in HIV and Aids , Volume 2 (3) – May 1, 2007
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3280eec766
pmid
19372889
Publisher site
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Abstract

Corticosteroids and HIV infection: a review of experience Robert S. Wallis Purpose of review Introduction Apoptosis caused by immune activation is thought to be an Corticosteroids exert broad inhibitory effects on both important mechanism for progressive CD4 T-cell depletion innate and acquired immunity, affecting T and B cells, in HIV disease. This review examines published literature on monocytes, and neutrophils. As a result, they have the effects of corticosteroids on activation markers and become first-line agents in the short-term management disease indicators in HIV. of a wide range of inflammatory, autoimmune, and aller- Recent findings gic conditions. Corticosteroids also play important Salutary effects were noted on activation markers, adjunctive therapeutic roles in certain infections in which apoptosis and circulating CD4 T-cell numbers in studies in the deleterious effects of the host immune response are which corticosteroids were administered together with prominent. Corticosteroids have been studied in HIV antiretroviral therapy. Safety concerns regarding infection, both to manage coincident inflammatory and osteonecrosis of the hip have limited further research in this infectious processes, and to determine effects on HIV area. Controlled trials in which corticosteroids were pathogenesis. Concerns regarding long-term metabolic administered in the absence of antiretroviral therapy have sequelae have,

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2007

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