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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of... Original article 497 Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin a a a a Ying Chen , Shuanglian Li , Chaline Brown , Stephen Cheatham , a a a a Richard A. Castro , Maya K. Leabman , Thomas J. Urban , Ligong Chen , a a a b Sook Wah Yee , Ji Ha Choi , Yong Huang , Claire M. Brett , a a Esteban G. Burchard and Kathleen M. Giacomini Objective The goal of this study was to determine secretion (SrCL ) of metformin were significantly different the effect of a genetic variant in the organic cation between the volunteers heterozygous for the variant allele transporter 2 (OCT2), OCT2-808G/T, which results (808G/T), and the volunteers homozygous for the in an amino acid change, A270S, on the pharmacokinetics reference allele (808G/G) (P < 0.005). Multivariate analysis of the antidiabetic drug, metformin. revealed that OCT2 genotype was a significant predictor of CL and SrCL of metformin (P < 0.01). R R Methods The uptake of metformin was performed in stably transfected HEK-293 cells expressing the empty Conclusion We conclude that genetic variation in OCT2 vector (MOCK), the reference OCT2-808G, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacogenetics & Genomics Wolters Kluwer Health

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

Pharmacogenetics & Genomics , Volume 19 (7) – Jul 1, 2009

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References (25)

ISSN
1744-6872
eISSN
1744-6880
DOI
10.1097/FPC.0b013e32832cc7e9
pmid
19483665
Publisher site
See Article on Publisher Site

Abstract

Original article 497 Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin a a a a Ying Chen , Shuanglian Li , Chaline Brown , Stephen Cheatham , a a a a Richard A. Castro , Maya K. Leabman , Thomas J. Urban , Ligong Chen , a a a b Sook Wah Yee , Ji Ha Choi , Yong Huang , Claire M. Brett , a a Esteban G. Burchard and Kathleen M. Giacomini Objective The goal of this study was to determine secretion (SrCL ) of metformin were significantly different the effect of a genetic variant in the organic cation between the volunteers heterozygous for the variant allele transporter 2 (OCT2), OCT2-808G/T, which results (808G/T), and the volunteers homozygous for the in an amino acid change, A270S, on the pharmacokinetics reference allele (808G/G) (P < 0.005). Multivariate analysis of the antidiabetic drug, metformin. revealed that OCT2 genotype was a significant predictor of CL and SrCL of metformin (P < 0.01). R R Methods The uptake of metformin was performed in stably transfected HEK-293 cells expressing the empty Conclusion We conclude that genetic variation in OCT2 vector (MOCK), the reference OCT2-808G,

Journal

Pharmacogenetics & GenomicsWolters Kluwer Health

Published: Jul 1, 2009

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