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Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate

Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate ORIGINAL ARTICLE Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate Hiang Ping Chan,*† Vanessa Tran, BMedSc,*† Craig Lewis, MB, BS (UNSW), MMed, FRACP,*‡ and Paul S. Thomas, BSc (Pharm), MB, BS, MHPEd, MD, FRCP, FRACP*† xidative stress has been implicated in the pathogenesis Introduction: Lung cancer is the leading cause of cancer death and Oof many respiratory conditions including lung cancer oxidative stress secondary to carcinogens such as cigarette smoke (Figure 1). This is based on the hypothesis that the lungs are has been implicated in its pathogenesis. Therefore, lung cancer directly exposed to higher oxygen concentrations compared patients were hypothesized to have higher levels of oxidative stress with other organs and hence more susceptible to increased markers in their exhaled breath compared with controls. oxidative stress, either through constant exposure to oxidants Methods: Exhaled breath condensate (EBC) was collected from derived internally from normal metabolic processes or expo- newly diagnosed subjects with non-small cell lung cancer (NSCLC) sure to ambient air containing environmental irritants or and control subjects in a cross-sectional observational study. The pollutants such as cigarette smoke and free-radical generating samples were then analyzed for hydrogen peroxide (H O ), pH, 2 2 environmental http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate

Journal of Thoracic Oncology , Volume 4 (2) – Feb 1, 2009

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ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181949eb9
pmid
19179892
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Elevated Levels of Oxidative Stress Markers in Exhaled Breath Condensate Hiang Ping Chan,*† Vanessa Tran, BMedSc,*† Craig Lewis, MB, BS (UNSW), MMed, FRACP,*‡ and Paul S. Thomas, BSc (Pharm), MB, BS, MHPEd, MD, FRCP, FRACP*† xidative stress has been implicated in the pathogenesis Introduction: Lung cancer is the leading cause of cancer death and Oof many respiratory conditions including lung cancer oxidative stress secondary to carcinogens such as cigarette smoke (Figure 1). This is based on the hypothesis that the lungs are has been implicated in its pathogenesis. Therefore, lung cancer directly exposed to higher oxygen concentrations compared patients were hypothesized to have higher levels of oxidative stress with other organs and hence more susceptible to increased markers in their exhaled breath compared with controls. oxidative stress, either through constant exposure to oxidants Methods: Exhaled breath condensate (EBC) was collected from derived internally from normal metabolic processes or expo- newly diagnosed subjects with non-small cell lung cancer (NSCLC) sure to ambient air containing environmental irritants or and control subjects in a cross-sectional observational study. The pollutants such as cigarette smoke and free-radical generating samples were then analyzed for hydrogen peroxide (H O ), pH, 2 2 environmental

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Feb 1, 2009

References