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EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers

EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers ORIGINAL ARTICLE EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Kentaro Inamura, MD, PhD,* Kengo Takeuchi, MD, PhD,* Yuki Togashi, MPharm,* Kimie Nomura,* Hironori Ninomiya, MD,* Michiyo Okui, PhD,* Yukitoshi Satoh, MD, PhD,*† Sakae Okumura, MD,† Ken Nakagawa, MD,† Manabu Soda, MD, PhD,‡ Young Lim Choi, MD, PhD,‡ Toshiro Niki, MD, PhD,§ Hiroyuki Mano, MD, PhD,‡ and Yuichi Ishikawa, MD, PhD* Keywords: Lung cancer, EML4-ALK, RT-PCR, Immunohisto- Introduction: Very recently, we have found a novel fusion product chemistry, Histology. between the echinoderm microtubule-associated protein-like4 (J Thorac Oncol. 2008;3: 13–17) (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs). Tumors featuring EML4-ALK fusion constitute one subtype of NSCLC that might be highly sensitive to ung cancer is the leading cause of cancer death in men and ALK inhibitors. Herein, we present results of a first large scale study Lwomen worldwide. Identification of activating mutations of EML4-ALK fusion in lung cancers. of the epidermal growth factor receptor (EGFR) is one of the Methods: Using reverse transcription-polymerase chain reaction for most intriguing recent discoveries in the field of lung cancer EML4-ALK fusion mRNA, we investigated 149 lung adenocarci- 1,2 research. EGFR mutations are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers

Ishikawa, Yuichi
Journal of Thoracic Oncology , Volume 3 (1) – Jan 1, 2008
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References (28)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e31815e8b60
pmid
18166835
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Kentaro Inamura, MD, PhD,* Kengo Takeuchi, MD, PhD,* Yuki Togashi, MPharm,* Kimie Nomura,* Hironori Ninomiya, MD,* Michiyo Okui, PhD,* Yukitoshi Satoh, MD, PhD,*† Sakae Okumura, MD,† Ken Nakagawa, MD,† Manabu Soda, MD, PhD,‡ Young Lim Choi, MD, PhD,‡ Toshiro Niki, MD, PhD,§ Hiroyuki Mano, MD, PhD,‡ and Yuichi Ishikawa, MD, PhD* Keywords: Lung cancer, EML4-ALK, RT-PCR, Immunohisto- Introduction: Very recently, we have found a novel fusion product chemistry, Histology. between the echinoderm microtubule-associated protein-like4 (J Thorac Oncol. 2008;3: 13–17) (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs). Tumors featuring EML4-ALK fusion constitute one subtype of NSCLC that might be highly sensitive to ung cancer is the leading cause of cancer death in men and ALK inhibitors. Herein, we present results of a first large scale study Lwomen worldwide. Identification of activating mutations of EML4-ALK fusion in lung cancers. of the epidermal growth factor receptor (EGFR) is one of the Methods: Using reverse transcription-polymerase chain reaction for most intriguing recent discoveries in the field of lung cancer EML4-ALK fusion mRNA, we investigated 149 lung adenocarci- 1,2 research. EGFR mutations are

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jan 1, 2008

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